hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00567
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SETDB1 | Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1) | UniProt NCBI |
| ATF7IP | Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) | UniProt NCBI |
| ARL14EP | ARL14 effector protein (ARF7 effector protein) | UniProt NCBI |
| KIRREL2 | Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) | UniProt NCBI |
| MCUB | Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUb) (Coiled-coil domain-containing protein 109B) | UniProt NCBI |
| CUL2 | Cullin-2 (CUL-2) | UniProt NCBI |
| VHL | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2749 | 1.007158685e-05 | 0.285714285714 | ATF7IP SETDB1 | SETDB1-containing HMTase complex |
| CORUM:2238 | 3.02079974644e-05 | 0.285714285714 | ATF7IP SETDB1 | MBD1-MCAF1-SETDB1 complex |
| CORUM:622 | 6.04024714829e-05 | 0.285714285714 | CUL2 VHL | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) |
| CORUM:205 | 0.000100648251269 | 0.285714285714 | CUL2 VHL | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) |
| WP:WP4241 | 0.00435375672817 | 0.285714285714 | CUL2 VHL | Type 2 papillary renal cell carcinoma |
| KEGG:05211 | 0.0191181203407 | 0.285714285714 | CUL2 VHL | Renal cell carcinoma |
| KEGG:04066 | 0.048055671732 | 0.285714285714 | CUL2 VHL | HIF-1 signaling pathway |
| CORUM:2759 | 0.0499886427319 | 0.142857142857 | ATF7IP | MBD1-MCAF complex |
| CORUM:6422 | 0.0499886427319 | 0.142857142857 | SETDB1 | SETDB1-DNMT3A complex |
| CORUM:6423 | 0.0499886427319 | 0.142857142857 | SETDB1 | SETDB1-DNMT3B complex |
| CORUM:6736 | 0.0499886427319 | 0.142857142857 | CUL2 | PRAME-Cullin2 ubiquitin ligase complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATF7IP | SETDB1 | 0.995 | 0.924 | hein_WMM bioplex (ATF7IP,SETDB1) bioplex_WMM Guru hein (SETDB1) Malo fraction |
| MCUB | SETDB1 | 0.863 | 0.8 | bioplex (SETDB1) bioplex_WMM |
| SETDB1 | ARL14EP | 0.449 | 0.593 | hein_WMM bioplex_WMM hein (SETDB1) boldt_WMM |
| ATF7IP | VHL | 0.306 | 0.501 | bioplex (VHL) bioplex_WMM |
| SETDB1 | VHL | 0.201 | 0.451 | bioplex (VHL) bioplex_WMM boldt (VHL) boldt_WMM |
| ATF7IP | ARL14EP | 0.141 | 0.405 | hein_WMM bioplex (ATF7IP) bioplex_WMM |
| CUL2 | VHL | 0.134 | 0.405 | bioplex (VHL) bioplex_WMM boldt (VHL) boldt_WMM |
| KIRREL2 | VHL | 0.061 | 0.335 | bioplex (KIRREL2) bioplex_WMM |
| ARL14EP | VHL | 0.045 | 0.287 | bioplex (VHL) bioplex_WMM boldt_WMM |
| MCUB | ARL14EP | 0.008 | 0.032 | bioplex_WMM WMM_only |
| ATF7IP | MCUB | 0.008 | 0.012 | bioplex_WMM WMM_only |
| CUL2 | ARL14EP | 0.007 | 0.006 | bioplex_WMM WMM_only boldt_WMM |
| ATF7IP | CUL2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| SETDB1 | CUL2 | 0.005 | 0.005 | bioplex (SETDB1) bioplex_WMM boldt boldt_WMM |
| CUL2 | KIRREL2 | 0.003 | 0.019 | bioplex (KIRREL2) |
Images
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Complex HuMAP2_00567 has an average edge precision of 0.318 which is ranked 4365 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SETDB1 | HuMAP2_00567 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 |
| ATF7IP | HuMAP2_00567 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 |
| ARL14EP | HuMAP2_00567 HuMAP2_01263 HuMAP2_02716 HuMAP2_04251 |
| KIRREL2 | HuMAP2_00567 HuMAP2_01263 HuMAP2_02018 HuMAP2_02716 |
| MCUB | HuMAP2_00567 HuMAP2_00894 HuMAP2_01263 HuMAP2_01516 HuMAP2_02716 HuMAP2_04380 |
| CUL2 | HuMAP2_00567 HuMAP2_00652 HuMAP2_02018 HuMAP2_02341 |
| VHL | HuMAP2_00567 HuMAP2_01263 HuMAP2_02018 HuMAP2_02716 |