hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00578
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | UniProt NCBI |
| CHMP2A | Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) | UniProt NCBI |
| STK24 | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | UniProt NCBI |
| CHMP2B | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | UniProt NCBI |
| C9orf78 | Telomere length and silencing protein 1 homolog (Hepatocellular carcinoma-associated antigen 59) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162588 | 8.88541585136e-06 | 0.6 | VTA1 CHMP2B CHMP2A | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 1.21879917622e-05 | 0.6 | VTA1 CHMP2B CHMP2A | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:1904896 | 0.000108905457596 | 0.6 | VTA1 CHMP2B CHMP2A | ESCRT complex disassembly |
| GO:1904903 | 0.000108905457596 | 0.6 | VTA1 CHMP2B CHMP2A | ESCRT III complex disassembly |
| CORUM:1186 | 0.000301566439547 | 0.4 | CHMP2B CHMP2A | ESCRT-III complex |
| REAC:R-HSA-162599 | 0.00102865345201 | 0.6 | VTA1 CHMP2B CHMP2A | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.00136170542712 | 0.6 | VTA1 CHMP2B CHMP2A | HIV Life Cycle |
| KEGG:04144 | 0.00171388219445 | 0.6 | VTA1 CHMP2B CHMP2A | Endocytosis |
| GO:0046755 | 0.00208420080219 | 0.6 | VTA1 CHMP2B CHMP2A | viral budding |
| GO:0071985 | 0.00265002518516 | 0.6 | VTA1 CHMP2B CHMP2A | multivesicular body sorting pathway |
| GO:0036258 | 0.00367721278555 | 0.6 | VTA1 CHMP2B CHMP2A | multivesicular body assembly |
| GO:0036257 | 0.00407078924856 | 0.6 | VTA1 CHMP2B CHMP2A | multivesicular body organization |
| REAC:R-HSA-9615710 | 0.00472180750517 | 0.4 | CHMP2B CHMP2A | Microautophagy |
| REAC:R-HSA-162906 | 0.00484900153486 | 0.6 | VTA1 CHMP2B CHMP2A | HIV Infection |
| GO:0019068 | 0.00826983957236 | 0.6 | VTA1 CHMP2B CHMP2A | virion assembly |
| REAC:R-HSA-5663205 | 0.0198891654246 | 0.6 | VTA1 CHMP2B CHMP2A | Infectious disease |
| KEGG:04217 | 0.0482876775804 | 0.4 | CHMP2B CHMP2A | Necroptosis |
| GO:0007032 | 0.0493791608738 | 0.6 | VTA1 CHMP2B CHMP2A | endosome organization |
| REAC:R-HSA-1632852 | 0.0499209306556 | 0.4 | CHMP2B CHMP2A | Macroautophagy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHMP2B | CHMP2A | 0.462 | 0.6 | hein_WMM Guru fraction |
| C9orf78 | STK24 | 0.064 | 0.348 | fraction |
| CHMP2B | STK24 | 0.057 | 0.318 | gupta_WMM fraction |
| CHMP2A | VTA1 | 0.041 | 0.268 | hein_WMM bioplex (CHMP2A) bioplex_WMM |
| CHMP2B | C9orf78 | 0.015 | 0.153 | bioplex_WMM gupta_WMM fraction |
| CHMP2B | VTA1 | 0.007 | 0.001 | hein_WMM WMM_only |
Images
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Complex HuMAP2_00578 has an average edge precision of 0.281 which is ranked 4864 out of all 6965 complexes.
Related Complexes