hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00581
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | UniProt NCBI |
| RBBP5 | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | UniProt NCBI |
| ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2730 | 6.80173643643e-13 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | Set1B complex |
| CORUM:6470 | 2.24457302402e-11 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | Set1B complex |
| GO:0048188 | 8.05053524616e-09 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | Set1C/COMPASS complex |
| CORUM:2731 | 1.3502580449e-08 | 0.75 | CXXC1 ASH2L RBBP5 | Set1A complex |
| GO:0042800 | 3.32999412455e-08 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone methyltransferase activity (H3-K4 specific) |
| CORUM:6469 | 8.09991585269e-08 | 0.75 | CXXC1 ASH2L RBBP5 | Set1A complex |
| GO:0051568 | 1.8007583612e-06 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone H3-K4 methylation |
| GO:0018024 | 2.00655931676e-06 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone-lysine N-methyltransferase activity |
| GO:0042054 | 4.74688832787e-06 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone methyltransferase activity |
| GO:0016279 | 6.60448834702e-06 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | protein-lysine N-methyltransferase activity |
| GO:0016278 | 7.1436302529e-06 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | lysine N-methyltransferase activity |
| CORUM:6850 | 1.50819606993e-05 | 0.5 | RBBP5 ASH2L | WRA complex (WDR5, RBBP5, ASH2L) |
| GO:0034968 | 1.98673792316e-05 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone lysine methylation |
| CORUM:1399 | 3.01612206104e-05 | 0.5 | RBBP5 ASH2L | WDR5-ASH2L-RBBP5-MLL2 complex |
| CORUM:6457 | 3.01612206104e-05 | 0.5 | RBBP5 ASH2L | MLL1 core complex |
| CORUM:6845 | 3.01612206104e-05 | 0.5 | RBBP5 ASH2L | NIF1-ASH2L-RBBP5-WDR5 complex |
| CORUM:7367 | 3.01612206104e-05 | 0.5 | RBBP5 ASH2L | ASH2L-KDM6B-KDM6B-WDR5 complex |
| CORUM:6849 | 3.01612206104e-05 | 0.5 | RBBP5 ASH2L | WRAD complex (WDR5, RBBP5, ASH2L, DPY30) |
| GO:0008276 | 3.12988953256e-05 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | protein methyltransferase activity |
| GO:0035097 | 3.85835319231e-05 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone methyltransferase complex |
| GO:0018022 | 4.05878712438e-05 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | peptidyl-lysine methylation |
| GO:0008170 | 4.70712600242e-05 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | N-methyltransferase activity |
| GO:0016571 | 4.93957666921e-05 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone methylation |
| CORUM:6340 | 5.02641999304e-05 | 0.5 | RBBP5 ASH2L | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| CORUM:6851 | 5.02641999304e-05 | 0.5 | RBBP5 ASH2L | MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30) |
| REAC:R-HSA-3214841 | 7.69213089466e-05 | 0.75 | RBBP5 SETD1B ASH2L | PKMTs methylate histone lysines |
| CORUM:1400 | 0.000105535916717 | 0.5 | RBBP5 ASH2L | ASCOM complex |
| CORUM:1256 | 0.000105535916717 | 0.5 | RBBP5 ASH2L | MLL-HCF complex |
| CORUM:1254 | 0.000105535916717 | 0.5 | RBBP5 ASH2L | Menin-associated histone methyltransferase complex |
| GO:0034708 | 0.000125895977869 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | methyltransferase complex |
| CORUM:6462 | 0.000140701954484 | 0.5 | RBBP5 ASH2L | MLL1 complex |
| GO:0006479 | 0.000168654810117 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | protein methylation |
| GO:0008213 | 0.000168654810117 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | protein alkylation |
| REAC:R-HSA-8936459 | 0.000168830825906 | 0.75 | RBBP5 SETD1B ASH2L | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| CORUM:6461 | 0.000180886312261 | 0.5 | RBBP5 ASH2L | MLL3 complex |
| CORUM:6467 | 0.000180886312261 | 0.5 | RBBP5 ASH2L | MLL4 complex |
| CORUM:6460 | 0.000226087640536 | 0.5 | RBBP5 ASH2L | MLL2 complex |
| CORUM:5195 | 0.000226087640536 | 0.5 | RBBP5 ASH2L | PTIP-HMT complex |
| CORUM:3075 | 0.000331535811226 | 0.5 | RBBP5 ASH2L | UTX-MLL2/3 complex |
| GO:0008757 | 0.000373974563235 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | S-adenosylmethionine-dependent methyltransferase activity |
| GO:0008168 | 0.000657808747052 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | methyltransferase activity |
| GO:0016741 | 0.000800055508379 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | transferase activity, transferring one-carbon groups |
| CORUM:5386 | 0.00176079969166 | 0.5 | RBBP5 ASH2L | MLL1-WDR5 complex |
| GO:0043414 | 0.0018126801061 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | macromolecule methylation |
| REAC:R-HSA-8878171 | 0.00230643324807 | 0.75 | RBBP5 SETD1B ASH2L | Transcriptional regulation by RUNX1 |
| GO:0032259 | 0.00244665292597 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | methylation |
| REAC:R-HSA-3247509 | 0.0042743665284 | 0.75 | RBBP5 SETD1B ASH2L | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 0.0042743665284 | 0.75 | RBBP5 SETD1B ASH2L | Chromatin organization |
| GO:0018205 | 0.00665909549353 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | peptidyl-lysine modification |
| REAC:R-HSA-3769402 | 0.00742649434549 | 0.5 | RBBP5 ASH2L | Deactivation of the beta-catenin transactivating complex |
| GO:0016570 | 0.0111323368581 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | histone modification |
| GO:0016569 | 0.0133451908966 | 1.0 | CXXC1 ASH2L SETD1B RBBP5 | covalent chromatin modification |
| KEGG:04934 | 0.0195308586359 | 0.5 | RBBP5 ASH2L | Cushing syndrome |
| REAC:R-HSA-201722 | 0.0390714342086 | 0.5 | RBBP5 ASH2L | Formation of the beta-catenin:TCF transactivating complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CXXC1 | SETD1B | 0.997 | 0.931 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1,SETD1B) |
| CXXC1 | ASH2L | 0.677 | 0.706 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| CXXC1 | RBBP5 | 0.617 | 0.675 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) |
| RBBP5 | SETD1B | 0.043 | 0.269 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| RBBP5 | ASH2L | 0.034 | 0.26 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ASH2L | SETD1B | 0.016 | 0.155 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
Images
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Complex HuMAP2_00581 has an average edge precision of 0.499 which is ranked 2500 out of all 6965 complexes.
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