hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00586
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) | UniProt NCBI |
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | UniProt NCBI |
| RPAIN | RPA-interacting protein (hRIP) | UniProt NCBI |
| SSRP1 | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | UniProt NCBI |
| RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | UniProt NCBI |
| TOM1L2 | TOM1-like protein 2 (Target of Myb-like protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1004 | 3.9447850026e-12 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 3.9447850026e-12 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | RC complex during G2/M-phase of cell cycle |
| KEGG:03420 | 4.66443887572e-12 | 0.6 | RPA2 XPC RPA1 RPA3 POLD1 RPA4 | Nucleotide excision repair |
| KEGG:03430 | 6.64563670838e-11 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | Mismatch repair |
| REAC:R-HSA-110373 | 4.56348216836e-10 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 7.41847244605e-10 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | DNA replication |
| REAC:R-HSA-5696399 | 1.15801934975e-09 | 0.6 | RPA2 XPC RPA1 RPA3 POLD1 PARP1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| KEGG:03440 | 1.29338115262e-09 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | Homologous recombination |
| WP:WP466 | 2.16976519083e-09 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | DNA Replication |
| REAC:R-HSA-73933 | 2.78055092912e-09 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | Resolution of Abasic Sites (AP sites) |
| GO:0006289 | 4.16653176281e-09 | 0.7 | RPA2 PARP1 RPA1 RPA3 POLD1 RPA4 XPC | nucleotide-excision repair |
| REAC:R-HSA-174437 | 4.49273987549e-09 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-5696398 | 6.06528121608e-09 | 0.6 | RPA2 XPC RPA1 RPA3 POLD1 PARP1 | Nucleotide Excision Repair |
| REAC:R-HSA-5696400 | 6.40798604659e-09 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | Dual Incision in GG-NER |
| REAC:R-HSA-174414 | 7.05774332729e-09 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-5696395 | 8.22641159017e-09 | 0.5 | RPA2 RPA1 XPC PARP1 RPA3 | Formation of Incision Complex in GG-NER |
| CORUM:5229 | 1.62176028613e-08 | 0.3 | RPA2 RPA1 RPA3 | RPA complex |
| REAC:R-HSA-69166 | 2.1387783748e-08 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358565 | 2.1387783748e-08 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358606 | 2.1387783748e-08 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69183 | 2.91557538595e-08 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Processive synthesis on the lagging strand |
| REAC:R-HSA-5358508 | 2.91557538595e-08 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Mismatch Repair |
| REAC:R-HSA-69186 | 1.03320119673e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Lagging Strand Synthesis |
| GO:0043601 | 1.09067223824e-07 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | nuclear replisome |
| REAC:R-HSA-5651801 | 1.27589564506e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | PCNA-Dependent Long Patch Base Excision Repair |
| GO:0030894 | 1.65632684457e-07 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | replisome |
| REAC:R-HSA-174417 | 2.26308267421e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Telomere C-strand (Lagging Strand) Synthesis |
| GO:0006294 | 2.43511577028e-07 | 0.5 | RPA2 RPA1 XPC PARP1 RPA3 | nucleotide-excision repair, preincision complex assembly |
| REAC:R-HSA-5696397 | 2.69327680603e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-73884 | 3.11899057137e-07 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | Base Excision Repair |
| CORUM:2738 | 3.24009105225e-07 | 0.3 | RPA2 RPA1 RPA3 | BLM complex II |
| CORUM:2222 | 3.24009105225e-07 | 0.3 | RPA2 RPA1 RPA3 | BLM complex II |
| GO:0006298 | 3.48213658537e-07 | 0.5 | RPA2 RPA1 XPC POLD1 RPA3 | mismatch repair |
| REAC:R-HSA-110314 | 5.82531573508e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 5.82531573508e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 6.686167013e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 7.63886760823e-07 | 0.4 | RPA2 RPA1 POLD1 RPA3 | DNA strand elongation |
| REAC:R-HSA-68962 | 8.68969903058e-07 | 0.4 | RPA4 RPA2 RPA1 RPA3 | Activation of the pre-replicative complex |
| GO:0006296 | 8.91821282591e-07 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| KEGG:03460 | 1.0286593557e-06 | 0.4 | RPA4 RPA2 RPA1 RPA3 | Fanconi anemia pathway |
| GO:0033683 | 1.17730687265e-06 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | nucleotide-excision repair, DNA incision |
| CORUM:248 | 1.35939923621e-06 | 0.3 | RPA2 RPA1 RPA3 | BRAFT complex |
| GO:0006281 | 1.52275413109e-06 | 0.8 | RPA2 PARP1 RPA1 RPA3 RPAIN POLD1 RPA4 XPC | DNA repair |
| GO:0043596 | 1.53150866514e-06 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | nuclear replication fork |
| REAC:R-HSA-110313 | 1.56499405738e-06 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-69306 | 2.03902622062e-06 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | DNA Replication |
| CORUM:244 | 2.66836560606e-06 | 0.3 | RPA2 RPA1 RPA3 | BRAFT complex |
| REAC:R-HSA-5693538 | 2.99664664154e-06 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | Homology Directed Repair |
| GO:0006261 | 3.48487412653e-06 | 0.6 | RPA2 RPA1 RPA3 RPAIN POLD1 RPA4 | DNA-dependent DNA replication |
| REAC:R-HSA-73893 | 3.77064335825e-06 | 0.4 | RPA2 RPA1 POLD1 RPA3 | DNA Damage Bypass |
| GO:0003684 | 3.88827404399e-06 | 0.5 | RPA2 RPA1 XPC POLD1 RPA3 | damaged DNA binding |
| REAC:R-HSA-73894 | 3.90842726551e-06 | 0.6 | RPA2 XPC RPA1 RPA3 POLD1 PARP1 | DNA Repair |
| GO:0032993 | 5.5275506413e-06 | 0.6 | RPA2 PARP1 RPA1 RPA3 POLD1 RPA4 | protein-DNA complex |
| REAC:R-HSA-5693532 | 7.67886065968e-06 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | DNA Double-Strand Break Repair |
| GO:0005662 | 9.28797042186e-06 | 0.4 | RPA4 RPA2 RPA1 RPA3 | DNA replication factor A complex |
| REAC:R-HSA-3371511 | 1.00000521116e-05 | 0.3 | RPA2 RPA1 RPA3 | HSF1 activation |
| REAC:R-HSA-6782210 | 1.33582958345e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.42296493277e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 1.42296493277e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | HDR through Homologous Recombination (HRR) |
| GO:0005657 | 1.54816312267e-05 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | replication fork |
| REAC:R-HSA-110312 | 2.54187883076e-05 | 0.3 | RPA2 RPA1 RPA3 | Translesion synthesis by REV1 |
| REAC:R-HSA-6781827 | 2.98540538601e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0090734 | 3.04219359068e-05 | 0.5 | RPA4 RPA2 RPA1 PARP1 RPA3 | site of DNA damage |
| GO:0006293 | 3.0493905917e-05 | 0.4 | RPA2 RPA1 PARP1 RPA3 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 3.0493905917e-05 | 0.4 | RPA2 RPA1 PARP1 RPA3 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| REAC:R-HSA-5656121 | 3.08547851834e-05 | 0.3 | RPA2 RPA1 RPA3 | Translesion synthesis by POLI |
| REAC:R-HSA-5655862 | 3.08547851834e-05 | 0.3 | RPA2 RPA1 RPA3 | Translesion synthesis by POLK |
| REAC:R-HSA-157579 | 3.47871152382e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Telomere Maintenance |
| REAC:R-HSA-69002 | 4.22814532204e-05 | 0.4 | RPA4 RPA2 RPA1 RPA3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-110320 | 4.39370578466e-05 | 0.3 | RPA2 RPA1 RPA3 | Translesion Synthesis by POLH |
| GO:0006297 | 4.50876096325e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | nucleotide-excision repair, DNA gap filling |
| GO:0006259 | 5.36366470765e-05 | 0.8 | RPA2 PARP1 RPA1 RPA3 RPAIN POLD1 RPA4 XPC | DNA metabolic process |
| GO:0006974 | 5.42393960193e-05 | 0.8 | RPA2 PARP1 RPA1 RPA3 RPAIN POLD1 RPA4 XPC | cellular response to DNA damage stimulus |
| REAC:R-HSA-6804756 | 5.57023092537e-05 | 0.4 | RPA2 SSRP1 RPA1 RPA3 | Regulation of TP53 Activity through Phosphorylation |
| GO:0006310 | 6.33875503629e-05 | 0.6 | RPA2 PARP1 RPA1 RPAIN RPA3 RPA4 | DNA recombination |
| GO:0006260 | 6.91869360711e-05 | 0.6 | RPA2 RPA1 RPA3 RPAIN POLD1 RPA4 | DNA replication |
| GO:0032201 | 8.9245265137e-05 | 0.4 | RPA2 RPA1 POLD1 RPA3 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 0.000111078314608 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Chromosome Maintenance |
| GO:0003697 | 0.00011662858759 | 0.5 | RPA4 RPA2 RPA1 XPC RPA3 | single-stranded DNA binding |
| REAC:R-HSA-69239 | 0.000158541722492 | 0.4 | RPA2 RPA1 POLD1 RPA3 | Synthesis of DNA |
| REAC:R-HSA-69206 | 0.000233764083353 | 0.4 | RPA4 RPA2 RPA1 RPA3 | G1/S Transition |
| REAC:R-HSA-5693567 | 0.000233764083353 | 0.4 | RPA2 RPA1 POLD1 RPA3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-6783310 | 0.000295097020196 | 0.3 | RPA2 RPA1 RPA3 | Fanconi Anemia Pathway |
| GO:0042769 | 0.000298674788131 | 0.4 | RPA2 RPA1 POLD1 RPA3 | DNA damage response, detection of DNA damage |
| CORUM:5231 | 0.000301566439547 | 0.2 | RPA2 RPA1 | 53BP1-containing complex |
| REAC:R-HSA-5685938 | 0.000321810414277 | 0.3 | RPA2 RPA1 RPA3 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 0.00035008185877 | 0.3 | RPA2 RPA1 RPA3 | Activation of ATR in response to replication stress |
| GO:0006284 | 0.000374033579713 | 0.4 | RPA2 RPA1 POLD1 RPA3 | base-excision repair |
| REAC:R-HSA-5693616 | 0.000379954732889 | 0.3 | RPA2 RPA1 RPA3 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-453279 | 0.000382153388735 | 0.4 | RPA4 RPA2 RPA1 RPA3 | Mitotic G1-G1/S phases |
| GO:0000724 | 0.000414093131115 | 0.5 | RPA4 RPA2 RPA1 PARP1 RPA3 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.000414093131115 | 0.5 | RPA4 RPA2 RPA1 PARP1 RPA3 | recombinational repair |
| GO:0019985 | 0.000462790237267 | 0.4 | RPA2 RPA1 POLD1 RPA3 | translesion synthesis |
| REAC:R-HSA-5693579 | 0.000479614787766 | 0.3 | RPA2 RPA1 RPA3 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5633007 | 0.000496940800765 | 0.4 | RPA2 SSRP1 RPA1 RPA3 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 0.000522666381847 | 0.4 | RPA2 RPA1 POLD1 RPA3 | S Phase |
| GO:0090305 | 0.000527624411971 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | nucleic acid phosphodiester bond hydrolysis |
| WP:WP45 | 0.000528977866642 | 0.3 | RPA2 RPA1 RPA3 | G1 to S cell cycle control |
| GO:0000781 | 0.000799374810829 | 0.5 | RPA4 RPA2 RPA1 PARP1 POLD1 | chromosome, telomeric region |
| GO:0000731 | 0.000824753618342 | 0.4 | RPA2 RPA1 POLD1 RPA3 | DNA synthesis involved in DNA repair |
| WP:WP531 | 0.000909494331361 | 0.2 | POLD1 RPA1 | DNA Mismatch Repair |
| WP:WP4016 | 0.00100802793413 | 0.3 | RPA2 PARP1 RPA1 | DNA IR-damage and cellular response via ATR |
| GO:0006301 | 0.00116245674185 | 0.4 | RPA2 RPA1 POLD1 RPA3 | postreplication repair |
| GO:0000723 | 0.00117253659511 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | telomere maintenance |
| GO:0033260 | 0.00136562237441 | 0.4 | RPA2 RPA1 POLD1 RPA3 | nuclear DNA replication |
| WP:WP2446 | 0.00140000217968 | 0.3 | RPA2 RPA1 RPA3 | Retinoblastoma Gene in Cancer |
| WP:WP186 | 0.00166561537104 | 0.2 | POLD1 RPA1 | Homologous recombination |
| GO:0035861 | 0.00171872239287 | 0.4 | RPA4 RPA2 PARP1 RPA3 | site of double-strand break |
| GO:0032200 | 0.001779797023 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | telomere organization |
| GO:0044786 | 0.0018503338385 | 0.4 | RPA2 RPA1 POLD1 RPA3 | cell cycle DNA replication |
| REAC:R-HSA-3371453 | 0.00194866452029 | 0.3 | RPA2 RPA1 RPA3 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-69278 | 0.00223411282221 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | Cell Cycle, Mitotic |
| CORUM:1098 | 0.00234548715066 | 0.2 | POLD1 RPA1 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-3108214 | 0.00254441551168 | 0.3 | RPA1 PARP1 XPC | SUMOylation of DNA damage response and repair proteins |
| GO:0065004 | 0.00373493901659 | 0.5 | RPA2 RPA1 XPC PARP1 RPA3 | protein-DNA complex assembly |
| CORUM:1111 | 0.0040837116275 | 0.2 | POLD1 RPA1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 0.0040837116275 | 0.2 | POLD1 RPA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-912446 | 0.00437532228124 | 0.3 | RPA2 RPA1 RPA3 | Meiotic recombination |
| REAC:R-HSA-3371556 | 0.00437532228124 | 0.3 | RPA2 RPA1 RPA3 | Cellular response to heat stress |
| GO:0003677 | 0.00504500200194 | 0.8 | RPA2 PARP1 SSRP1 RPA1 RPA3 POLD1 RPA4 XPC | DNA binding |
| REAC:R-HSA-1640170 | 0.00536344984968 | 0.5 | RPA4 RPA2 RPA1 POLD1 RPA3 | Cell Cycle |
| GO:0006283 | 0.00545324499353 | 0.4 | RPA2 RPA1 POLD1 RPA3 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-69473 | 0.00591902969631 | 0.3 | RPA2 RPA1 RPA3 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.0065036589814 | 0.3 | RPA2 RPA1 RPA3 | Processing of DNA double-strand break ends |
| KEGG:03410 | 0.00957194146723 | 0.2 | POLD1 PARP1 | Base excision repair |
| GO:0006302 | 0.00973448831007 | 0.5 | RPA4 RPA2 RPA1 PARP1 RPA3 | double-strand break repair |
| REAC:R-HSA-1500620 | 0.0105434097806 | 0.3 | RPA2 RPA1 RPA3 | Meiosis |
| GO:0071824 | 0.0113085018911 | 0.5 | RPA2 RPA1 XPC PARP1 RPA3 | protein-DNA complex subunit organization |
| REAC:R-HSA-3700989 | 0.0115134084843 | 0.4 | RPA2 SSRP1 RPA1 RPA3 | Transcriptional Regulation by TP53 |
| GO:0042276 | 0.0123497091753 | 0.3 | RPA2 RPA1 RPA3 | error-prone translesion synthesis |
| GO:0070987 | 0.0123497091753 | 0.3 | RPA2 RPA1 RPA3 | error-free translesion synthesis |
| REAC:R-HSA-1474165 | 0.014550106919 | 0.3 | RPA2 RPA1 RPA3 | Reproduction |
| GO:0044454 | 0.0181227164942 | 0.7 | RPA2 PARP1 SSRP1 RPA1 RPA3 POLD1 RPA4 | nuclear chromosome part |
| GO:0000228 | 0.0217407747409 | 0.7 | RPA2 PARP1 SSRP1 RPA1 RPA3 POLD1 RPA4 | nuclear chromosome |
| GO:0098687 | 0.0233146434038 | 0.5 | RPA4 RPA2 RPA1 PARP1 POLD1 | chromosomal region |
| GO:0033554 | 0.0269380657501 | 0.8 | RPA2 PARP1 RPA1 RPA3 RPAIN POLD1 RPA4 XPC | cellular response to stress |
| GO:0060249 | 0.0273820182452 | 0.5 | RPA2 RPA1 PARP1 POLD1 RPA3 | anatomical structure homeostasis |
| REAC:R-HSA-3108232 | 0.0322269756455 | 0.3 | RPA1 PARP1 XPC | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-69481 | 0.0328048670167 | 0.3 | RPA2 RPA1 RPA3 | G2/M Checkpoints |
| REAC:R-HSA-2990846 | 0.0357959362763 | 0.3 | RPA1 PARP1 XPC | SUMOylation |
| GO:0000784 | 0.0378914716756 | 0.4 | RPA2 RPA1 PARP1 POLD1 | nuclear chromosome, telomeric region |
| HPA:014010_12 | 0.0388602233948 | 0.4 | RPA2 XPC PARP1 RPA1 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA3 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPA3 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPAIN | 0.304 | 0.499 | bioplex (RPA2,RPAIN) bioplex_WMM |
| RPA3 | POLD1 | 0.263 | 0.482 | youn_WMM gupta_WMM fraction |
| RPA3 | TOM1L2 | 0.251 | 0.474 | bioplex_WMM fraction |
| RPA2 | XPC | 0.171 | 0.43 | bioplex (RPA2,XPC) bioplex_WMM |
| PARP1 | RPA2 | 0.165 | 0.42 | bioplex (RPA2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | RPA4 | 0.128 | 0.399 | bioplex (RPA4) bioplex_WMM |
| PARP1 | XPC | 0.112 | 0.381 | bioplex (XPC) bioplex_WMM gupta_WMM |
| PARP1 | RPA1 | 0.104 | 0.368 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPA1 | RPA4 | 0.1 | 0.361 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA3 | 0.1 | 0.36 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SSRP1 | XPC | 0.069 | 0.348 | bioplex (SSRP1,XPC) bioplex_WMM gupta_WMM |
| PARP1 | SSRP1 | 0.066 | 0.35 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPA1 | SSRP1 | 0.054 | 0.303 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPA1 | XPC | 0.048 | 0.294 | bioplex (XPC) bioplex_WMM gupta_WMM |
| RPA3 | RPAIN | 0.041 | 0.27 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | RPAIN | 0.034 | 0.257 | bioplex (RPAIN) bioplex_WMM |
| RPA2 | SSRP1 | 0.03 | 0.235 | bioplex (RPA2,SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | SSRP1 | 0.025 | 0.213 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | XPC | 0.024 | 0.211 | bioplex (XPC) bioplex_WMM |
| POLD1 | SSRP1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RPAIN | XPC | 0.007 | 0.003 | bioplex_WMM WMM_only |
| POLD1 | RPA1 | 0.007 | 0.01 | youn_WMM gupta_WMM WMM_only |
| RPAIN | SSRP1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RPA2 | POLD1 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| PARP1 | TOM1L2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PARP1 | POLD1 | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| POLD1 | TOM1L2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| TOM1L2 | SSRP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| TOM1L2 | XPC | 0.007 | 0.001 | bioplex_WMM WMM_only |
| RPA2 | RPA4 | 0.006 | 0.004 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA4 | 0.005 | 0.013 | bioplex (RPA4) bioplex_WMM |
| RPA4 | XPC | 0.004 | 0.013 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPAIN | 0.0 | 0.017 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | TOM1L2 | 0.0 | 0.008 | bioplex_WMM fraction |
| RPA2 | TOM1L2 | 0.0 | 0.002 | bioplex_WMM fraction |
| RPA4 | SSRP1 | 0.0 | 0.001 | bioplex (RPA4) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_00586 has an average edge precision of 0.246 which is ranked 5430 out of all 6965 complexes.
Related Complexes