hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00586
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) | UniProt NCBI |
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | UniProt NCBI |
| RPAIN | RPA-interacting protein (hRIP) | UniProt NCBI |
| SSRP1 | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | UniProt NCBI |
| RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | UniProt NCBI |
| TOM1L2 | TOM1-like protein 2 (Target of Myb-like protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1004 | 3.9447850026e-12 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 3.9447850026e-12 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | RC complex during G2/M-phase of cell cycle |
| KEGG:03420 | 4.66443887572e-12 | 0.6 | POLD1 RPA4 RPA3 RPA1 XPC RPA2 | Nucleotide excision repair |
| KEGG:03430 | 6.64563670838e-11 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | Mismatch repair |
| REAC:R-HSA-110373 | 4.56348216836e-10 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 7.41847244605e-10 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | DNA replication |
| REAC:R-HSA-5696399 | 1.15801934975e-09 | 0.6 | POLD1 RPA2 RPA3 RPA1 XPC PARP1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| KEGG:03440 | 1.29338115262e-09 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | Homologous recombination |
| WP:WP466 | 2.16976519083e-09 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | DNA Replication |
| REAC:R-HSA-73933 | 2.78055092912e-09 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | Resolution of Abasic Sites (AP sites) |
| GO:0006289 | 4.16653176281e-09 | 0.7 | POLD1 RPA4 RPA3 PARP1 RPA1 XPC RPA2 | nucleotide-excision repair |
| REAC:R-HSA-174437 | 4.49273987549e-09 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-5696398 | 6.06528121608e-09 | 0.6 | POLD1 RPA2 RPA3 RPA1 XPC PARP1 | Nucleotide Excision Repair |
| REAC:R-HSA-5696400 | 6.40798604659e-09 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | Dual Incision in GG-NER |
| REAC:R-HSA-174414 | 7.05774332729e-09 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-5696395 | 8.22641159017e-09 | 0.5 | PARP1 RPA3 RPA2 XPC RPA1 | Formation of Incision Complex in GG-NER |
| CORUM:5229 | 1.62176028613e-08 | 0.3 | RPA3 RPA2 RPA1 | RPA complex |
| REAC:R-HSA-69166 | 2.1387783748e-08 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358565 | 2.1387783748e-08 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358606 | 2.1387783748e-08 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69183 | 2.91557538595e-08 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Processive synthesis on the lagging strand |
| REAC:R-HSA-5358508 | 2.91557538595e-08 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Mismatch Repair |
| REAC:R-HSA-69186 | 1.03320119673e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Lagging Strand Synthesis |
| GO:0043601 | 1.09067223824e-07 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | nuclear replisome |
| REAC:R-HSA-5651801 | 1.27589564506e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | PCNA-Dependent Long Patch Base Excision Repair |
| GO:0030894 | 1.65632684457e-07 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | replisome |
| REAC:R-HSA-174417 | 2.26308267421e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Telomere C-strand (Lagging Strand) Synthesis |
| GO:0006294 | 2.43511577028e-07 | 0.5 | PARP1 RPA3 RPA2 XPC RPA1 | nucleotide-excision repair, preincision complex assembly |
| REAC:R-HSA-5696397 | 2.69327680603e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-73884 | 3.11899057137e-07 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | Base Excision Repair |
| CORUM:2738 | 3.24009105225e-07 | 0.3 | RPA3 RPA2 RPA1 | BLM complex II |
| CORUM:2222 | 3.24009105225e-07 | 0.3 | RPA3 RPA2 RPA1 | BLM complex II |
| GO:0006298 | 3.48213658537e-07 | 0.5 | RPA1 RPA3 RPA2 XPC POLD1 | mismatch repair |
| REAC:R-HSA-110314 | 5.82531573508e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 5.82531573508e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 6.686167013e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 7.63886760823e-07 | 0.4 | RPA1 RPA3 RPA2 POLD1 | DNA strand elongation |
| REAC:R-HSA-68962 | 8.68969903058e-07 | 0.4 | RPA3 RPA4 RPA2 RPA1 | Activation of the pre-replicative complex |
| GO:0006296 | 8.91821282591e-07 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| KEGG:03460 | 1.0286593557e-06 | 0.4 | RPA3 RPA4 RPA2 RPA1 | Fanconi anemia pathway |
| GO:0033683 | 1.17730687265e-06 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | nucleotide-excision repair, DNA incision |
| CORUM:248 | 1.35939923621e-06 | 0.3 | RPA3 RPA2 RPA1 | BRAFT complex |
| GO:0006281 | 1.52275413109e-06 | 0.8 | RPAIN RPA4 POLD1 RPA3 PARP1 RPA1 XPC RPA2 | DNA repair |
| GO:0043596 | 1.53150866514e-06 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | nuclear replication fork |
| REAC:R-HSA-110313 | 1.56499405738e-06 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-69306 | 2.03902622062e-06 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | DNA Replication |
| CORUM:244 | 2.66836560606e-06 | 0.3 | RPA3 RPA2 RPA1 | BRAFT complex |
| REAC:R-HSA-5693538 | 2.99664664154e-06 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | Homology Directed Repair |
| GO:0006261 | 3.48487412653e-06 | 0.6 | RPAIN RPA4 POLD1 RPA3 RPA1 RPA2 | DNA-dependent DNA replication |
| REAC:R-HSA-73893 | 3.77064335825e-06 | 0.4 | RPA1 RPA3 RPA2 POLD1 | DNA Damage Bypass |
| GO:0003684 | 3.88827404399e-06 | 0.5 | RPA1 RPA3 RPA2 XPC POLD1 | damaged DNA binding |
| REAC:R-HSA-73894 | 3.90842726551e-06 | 0.6 | POLD1 RPA2 RPA3 RPA1 XPC PARP1 | DNA Repair |
| GO:0032993 | 5.5275506413e-06 | 0.6 | POLD1 RPA4 RPA3 PARP1 RPA1 RPA2 | protein-DNA complex |
| REAC:R-HSA-5693532 | 7.67886065968e-06 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | DNA Double-Strand Break Repair |
| GO:0005662 | 9.28797042186e-06 | 0.4 | RPA3 RPA4 RPA2 RPA1 | DNA replication factor A complex |
| REAC:R-HSA-3371511 | 1.00000521116e-05 | 0.3 | RPA3 RPA2 RPA1 | HSF1 activation |
| REAC:R-HSA-6782210 | 1.33582958345e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.42296493277e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 1.42296493277e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | HDR through Homologous Recombination (HRR) |
| GO:0005657 | 1.54816312267e-05 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | replication fork |
| REAC:R-HSA-110312 | 2.54187883076e-05 | 0.3 | RPA3 RPA2 RPA1 | Translesion synthesis by REV1 |
| REAC:R-HSA-6781827 | 2.98540538601e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0090734 | 3.04219359068e-05 | 0.5 | PARP1 RPA3 RPA4 RPA2 RPA1 | site of DNA damage |
| GO:0006293 | 3.0493905917e-05 | 0.4 | PARP1 RPA3 RPA2 RPA1 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 3.0493905917e-05 | 0.4 | PARP1 RPA3 RPA2 RPA1 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| REAC:R-HSA-5656121 | 3.08547851834e-05 | 0.3 | RPA3 RPA2 RPA1 | Translesion synthesis by POLI |
| REAC:R-HSA-5655862 | 3.08547851834e-05 | 0.3 | RPA3 RPA2 RPA1 | Translesion synthesis by POLK |
| REAC:R-HSA-157579 | 3.47871152382e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Telomere Maintenance |
| REAC:R-HSA-69002 | 4.22814532204e-05 | 0.4 | RPA3 RPA4 RPA2 RPA1 | DNA Replication Pre-Initiation |
| REAC:R-HSA-110320 | 4.39370578466e-05 | 0.3 | RPA3 RPA2 RPA1 | Translesion Synthesis by POLH |
| GO:0006297 | 4.50876096325e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | nucleotide-excision repair, DNA gap filling |
| GO:0006259 | 5.36366470765e-05 | 0.8 | RPAIN RPA4 POLD1 RPA3 PARP1 RPA1 XPC RPA2 | DNA metabolic process |
| GO:0006974 | 5.42393960193e-05 | 0.8 | RPAIN RPA4 POLD1 RPA3 PARP1 RPA1 XPC RPA2 | cellular response to DNA damage stimulus |
| REAC:R-HSA-6804756 | 5.57023092537e-05 | 0.4 | SSRP1 RPA3 RPA2 RPA1 | Regulation of TP53 Activity through Phosphorylation |
| GO:0006310 | 6.33875503629e-05 | 0.6 | RPAIN RPA4 RPA3 RPA1 PARP1 RPA2 | DNA recombination |
| GO:0006260 | 6.91869360711e-05 | 0.6 | RPAIN RPA4 POLD1 RPA3 RPA1 RPA2 | DNA replication |
| GO:0032201 | 8.9245265137e-05 | 0.4 | RPA1 RPA3 RPA2 POLD1 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 0.000111078314608 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Chromosome Maintenance |
| GO:0003697 | 0.00011662858759 | 0.5 | RPA3 RPA4 RPA2 XPC RPA1 | single-stranded DNA binding |
| REAC:R-HSA-69239 | 0.000158541722492 | 0.4 | RPA1 RPA3 RPA2 POLD1 | Synthesis of DNA |
| REAC:R-HSA-69206 | 0.000233764083353 | 0.4 | RPA3 RPA4 RPA2 RPA1 | G1/S Transition |
| REAC:R-HSA-5693567 | 0.000233764083353 | 0.4 | RPA1 RPA3 RPA2 POLD1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-6783310 | 0.000295097020196 | 0.3 | RPA3 RPA2 RPA1 | Fanconi Anemia Pathway |
| GO:0042769 | 0.000298674788131 | 0.4 | RPA1 RPA3 RPA2 POLD1 | DNA damage response, detection of DNA damage |
| CORUM:5231 | 0.000301566439547 | 0.2 | RPA2 RPA1 | 53BP1-containing complex |
| REAC:R-HSA-5685938 | 0.000321810414277 | 0.3 | RPA3 RPA2 RPA1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 0.00035008185877 | 0.3 | RPA3 RPA2 RPA1 | Activation of ATR in response to replication stress |
| GO:0006284 | 0.000374033579713 | 0.4 | RPA1 RPA3 RPA2 POLD1 | base-excision repair |
| REAC:R-HSA-5693616 | 0.000379954732889 | 0.3 | RPA3 RPA2 RPA1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-453279 | 0.000382153388735 | 0.4 | RPA3 RPA4 RPA2 RPA1 | Mitotic G1-G1/S phases |
| GO:0000724 | 0.000414093131115 | 0.5 | PARP1 RPA3 RPA4 RPA2 RPA1 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.000414093131115 | 0.5 | PARP1 RPA3 RPA4 RPA2 RPA1 | recombinational repair |
| GO:0019985 | 0.000462790237267 | 0.4 | RPA1 RPA3 RPA2 POLD1 | translesion synthesis |
| REAC:R-HSA-5693579 | 0.000479614787766 | 0.3 | RPA3 RPA2 RPA1 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5633007 | 0.000496940800765 | 0.4 | SSRP1 RPA3 RPA2 RPA1 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 0.000522666381847 | 0.4 | RPA1 RPA3 RPA2 POLD1 | S Phase |
| GO:0090305 | 0.000527624411971 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | nucleic acid phosphodiester bond hydrolysis |
| WP:WP45 | 0.000528977866642 | 0.3 | RPA3 RPA2 RPA1 | G1 to S cell cycle control |
| GO:0000781 | 0.000799374810829 | 0.5 | PARP1 POLD1 RPA4 RPA2 RPA1 | chromosome, telomeric region |
| GO:0000731 | 0.000824753618342 | 0.4 | RPA1 RPA3 RPA2 POLD1 | DNA synthesis involved in DNA repair |
| WP:WP531 | 0.000909494331361 | 0.2 | POLD1 RPA1 | DNA Mismatch Repair |
| WP:WP4016 | 0.00100802793413 | 0.3 | PARP1 RPA2 RPA1 | DNA IR-damage and cellular response via ATR |
| GO:0006301 | 0.00116245674185 | 0.4 | RPA1 RPA3 RPA2 POLD1 | postreplication repair |
| GO:0000723 | 0.00117253659511 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | telomere maintenance |
| GO:0033260 | 0.00136562237441 | 0.4 | RPA1 RPA3 RPA2 POLD1 | nuclear DNA replication |
| WP:WP2446 | 0.00140000217968 | 0.3 | RPA3 RPA2 RPA1 | Retinoblastoma Gene in Cancer |
| WP:WP186 | 0.00166561537104 | 0.2 | POLD1 RPA1 | Homologous recombination |
| GO:0035861 | 0.00171872239287 | 0.4 | PARP1 RPA3 RPA2 RPA4 | site of double-strand break |
| GO:0032200 | 0.001779797023 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | telomere organization |
| GO:0044786 | 0.0018503338385 | 0.4 | RPA1 RPA3 RPA2 POLD1 | cell cycle DNA replication |
| REAC:R-HSA-3371453 | 0.00194866452029 | 0.3 | RPA3 RPA2 RPA1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-69278 | 0.00223411282221 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | Cell Cycle, Mitotic |
| CORUM:1098 | 0.00234548715066 | 0.2 | POLD1 RPA1 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-3108214 | 0.00254441551168 | 0.3 | RPA1 XPC PARP1 | SUMOylation of DNA damage response and repair proteins |
| GO:0065004 | 0.00373493901659 | 0.5 | PARP1 RPA3 RPA2 XPC RPA1 | protein-DNA complex assembly |
| CORUM:1111 | 0.0040837116275 | 0.2 | POLD1 RPA1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 0.0040837116275 | 0.2 | POLD1 RPA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-912446 | 0.00437532228124 | 0.3 | RPA3 RPA2 RPA1 | Meiotic recombination |
| REAC:R-HSA-3371556 | 0.00437532228124 | 0.3 | RPA3 RPA2 RPA1 | Cellular response to heat stress |
| GO:0003677 | 0.00504500200194 | 0.8 | POLD1 RPA4 RPA3 PARP1 SSRP1 RPA1 XPC RPA2 | DNA binding |
| REAC:R-HSA-1640170 | 0.00536344984968 | 0.5 | RPA1 RPA3 RPA4 RPA2 POLD1 | Cell Cycle |
| GO:0006283 | 0.00545324499353 | 0.4 | RPA1 RPA3 RPA2 POLD1 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-69473 | 0.00591902969631 | 0.3 | RPA3 RPA2 RPA1 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.0065036589814 | 0.3 | RPA3 RPA2 RPA1 | Processing of DNA double-strand break ends |
| KEGG:03410 | 0.00957194146723 | 0.2 | POLD1 PARP1 | Base excision repair |
| GO:0006302 | 0.00973448831007 | 0.5 | PARP1 RPA3 RPA4 RPA2 RPA1 | double-strand break repair |
| REAC:R-HSA-1500620 | 0.0105434097806 | 0.3 | RPA3 RPA2 RPA1 | Meiosis |
| GO:0071824 | 0.0113085018911 | 0.5 | PARP1 RPA3 RPA2 XPC RPA1 | protein-DNA complex subunit organization |
| REAC:R-HSA-3700989 | 0.0115134084843 | 0.4 | SSRP1 RPA3 RPA2 RPA1 | Transcriptional Regulation by TP53 |
| GO:0042276 | 0.0123497091753 | 0.3 | RPA3 RPA2 RPA1 | error-prone translesion synthesis |
| GO:0070987 | 0.0123497091753 | 0.3 | RPA3 RPA2 RPA1 | error-free translesion synthesis |
| REAC:R-HSA-1474165 | 0.014550106919 | 0.3 | RPA3 RPA2 RPA1 | Reproduction |
| GO:0044454 | 0.0181227164942 | 0.7 | POLD1 RPA4 RPA3 PARP1 SSRP1 RPA1 RPA2 | nuclear chromosome part |
| GO:0000228 | 0.0217407747409 | 0.7 | POLD1 RPA4 RPA3 PARP1 SSRP1 RPA1 RPA2 | nuclear chromosome |
| GO:0098687 | 0.0233146434038 | 0.5 | PARP1 POLD1 RPA4 RPA2 RPA1 | chromosomal region |
| GO:0033554 | 0.0269380657501 | 0.8 | RPAIN RPA4 POLD1 RPA3 PARP1 RPA1 XPC RPA2 | cellular response to stress |
| GO:0060249 | 0.0273820182452 | 0.5 | RPA1 RPA3 PARP1 RPA2 POLD1 | anatomical structure homeostasis |
| REAC:R-HSA-3108232 | 0.0322269756455 | 0.3 | RPA1 XPC PARP1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-69481 | 0.0328048670167 | 0.3 | RPA3 RPA2 RPA1 | G2/M Checkpoints |
| REAC:R-HSA-2990846 | 0.0357959362763 | 0.3 | RPA1 XPC PARP1 | SUMOylation |
| GO:0000784 | 0.0378914716756 | 0.4 | PARP1 POLD1 RPA2 RPA1 | nuclear chromosome, telomeric region |
| HPA:014010_12 | 0.0388602233948 | 0.4 | PARP1 RPA2 XPC RPA1 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA3 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPA3 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPAIN | 0.304 | 0.499 | bioplex (RPA2,RPAIN) bioplex_WMM |
| RPA3 | POLD1 | 0.263 | 0.482 | youn_WMM gupta_WMM fraction |
| RPA3 | TOM1L2 | 0.251 | 0.474 | bioplex_WMM fraction |
| RPA2 | XPC | 0.171 | 0.43 | bioplex (RPA2,XPC) bioplex_WMM |
| PARP1 | RPA2 | 0.165 | 0.42 | bioplex (RPA2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | RPA4 | 0.128 | 0.399 | bioplex (RPA4) bioplex_WMM |
| PARP1 | XPC | 0.112 | 0.381 | bioplex (XPC) bioplex_WMM gupta_WMM |
| PARP1 | RPA1 | 0.104 | 0.368 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPA1 | RPA4 | 0.1 | 0.361 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA3 | 0.1 | 0.36 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SSRP1 | XPC | 0.069 | 0.348 | bioplex (SSRP1,XPC) bioplex_WMM gupta_WMM |
| PARP1 | SSRP1 | 0.066 | 0.35 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPA1 | SSRP1 | 0.054 | 0.303 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPA1 | XPC | 0.048 | 0.294 | bioplex (XPC) bioplex_WMM gupta_WMM |
| RPA3 | RPAIN | 0.041 | 0.27 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | RPAIN | 0.034 | 0.257 | bioplex (RPAIN) bioplex_WMM |
| RPA2 | SSRP1 | 0.03 | 0.235 | bioplex (RPA2,SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | SSRP1 | 0.025 | 0.213 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | XPC | 0.024 | 0.211 | bioplex (XPC) bioplex_WMM |
| POLD1 | SSRP1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RPAIN | XPC | 0.007 | 0.003 | bioplex_WMM WMM_only |
| POLD1 | RPA1 | 0.007 | 0.01 | youn_WMM gupta_WMM WMM_only |
| RPAIN | SSRP1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RPA2 | POLD1 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| PARP1 | TOM1L2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PARP1 | POLD1 | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| POLD1 | TOM1L2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| TOM1L2 | SSRP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| TOM1L2 | XPC | 0.007 | 0.001 | bioplex_WMM WMM_only |
| RPA2 | RPA4 | 0.006 | 0.004 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA4 | 0.005 | 0.013 | bioplex (RPA4) bioplex_WMM |
| RPA4 | XPC | 0.004 | 0.013 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPAIN | 0.0 | 0.017 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | TOM1L2 | 0.0 | 0.008 | bioplex_WMM fraction |
| RPA2 | TOM1L2 | 0.0 | 0.002 | bioplex_WMM fraction |
| RPA4 | SSRP1 | 0.0 | 0.001 | bioplex (RPA4) bioplex_WMM |
Images
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Complex HuMAP2_00586 has an average edge precision of 0.246 which is ranked 5430 out of all 6965 complexes.
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