hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00586
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
| PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) | UniProt NCBI |
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | UniProt NCBI |
| RPAIN | RPA-interacting protein (hRIP) | UniProt NCBI |
| SSRP1 | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | UniProt NCBI |
| XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | UniProt NCBI |
| RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | UniProt NCBI |
| TOM1L2 | TOM1-like protein 2 (Target of Myb-like protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1004 | 3.9447850026e-12 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 3.9447850026e-12 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | RC complex during G2/M-phase of cell cycle |
| KEGG:03420 | 4.66443887572e-12 | 0.6 | XPC RPA2 RPA1 POLD1 RPA4 RPA3 | Nucleotide excision repair |
| KEGG:03430 | 6.64563670838e-11 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | Mismatch repair |
| REAC:R-HSA-110373 | 4.56348216836e-10 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 7.41847244605e-10 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | DNA replication |
| REAC:R-HSA-5696399 | 1.15801934975e-09 | 0.6 | XPC RPA2 RPA1 PARP1 POLD1 RPA3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| KEGG:03440 | 1.29338115262e-09 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | Homologous recombination |
| WP:WP466 | 2.16976519083e-09 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | DNA Replication |
| REAC:R-HSA-73933 | 2.78055092912e-09 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | Resolution of Abasic Sites (AP sites) |
| GO:0006289 | 4.16653176281e-09 | 0.7 | XPC RPA2 RPA1 PARP1 POLD1 RPA4 RPA3 | nucleotide-excision repair |
| REAC:R-HSA-174437 | 4.49273987549e-09 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-5696398 | 6.06528121608e-09 | 0.6 | XPC RPA2 RPA1 PARP1 POLD1 RPA3 | Nucleotide Excision Repair |
| REAC:R-HSA-5696400 | 6.40798604659e-09 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | Dual Incision in GG-NER |
| REAC:R-HSA-174414 | 7.05774332729e-09 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-5696395 | 8.22641159017e-09 | 0.5 | RPA1 PARP1 RPA2 XPC RPA3 | Formation of Incision Complex in GG-NER |
| CORUM:5229 | 1.62176028613e-08 | 0.3 | RPA1 RPA2 RPA3 | RPA complex |
| REAC:R-HSA-69166 | 2.1387783748e-08 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358565 | 2.1387783748e-08 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358606 | 2.1387783748e-08 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69183 | 2.91557538595e-08 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Processive synthesis on the lagging strand |
| REAC:R-HSA-5358508 | 2.91557538595e-08 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Mismatch Repair |
| REAC:R-HSA-69186 | 1.03320119673e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Lagging Strand Synthesis |
| GO:0043601 | 1.09067223824e-07 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | nuclear replisome |
| REAC:R-HSA-5651801 | 1.27589564506e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | PCNA-Dependent Long Patch Base Excision Repair |
| GO:0030894 | 1.65632684457e-07 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | replisome |
| REAC:R-HSA-174417 | 2.26308267421e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Telomere C-strand (Lagging Strand) Synthesis |
| GO:0006294 | 2.43511577028e-07 | 0.5 | RPA1 PARP1 RPA2 XPC RPA3 | nucleotide-excision repair, preincision complex assembly |
| REAC:R-HSA-5696397 | 2.69327680603e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-73884 | 3.11899057137e-07 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | Base Excision Repair |
| CORUM:2738 | 3.24009105225e-07 | 0.3 | RPA1 RPA2 RPA3 | BLM complex II |
| CORUM:2222 | 3.24009105225e-07 | 0.3 | RPA1 RPA2 RPA3 | BLM complex II |
| GO:0006298 | 3.48213658537e-07 | 0.5 | POLD1 XPC RPA2 RPA1 RPA3 | mismatch repair |
| REAC:R-HSA-110314 | 5.82531573508e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 5.82531573508e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 6.686167013e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 7.63886760823e-07 | 0.4 | POLD1 RPA2 RPA1 RPA3 | DNA strand elongation |
| REAC:R-HSA-68962 | 8.68969903058e-07 | 0.4 | RPA1 RPA4 RPA2 RPA3 | Activation of the pre-replicative complex |
| GO:0006296 | 8.91821282591e-07 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| KEGG:03460 | 1.0286593557e-06 | 0.4 | RPA1 RPA4 RPA2 RPA3 | Fanconi anemia pathway |
| GO:0033683 | 1.17730687265e-06 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | nucleotide-excision repair, DNA incision |
| CORUM:248 | 1.35939923621e-06 | 0.3 | RPA1 RPA2 RPA3 | BRAFT complex |
| GO:0006281 | 1.52275413109e-06 | 0.8 | XPC RPA3 RPAIN RPA1 PARP1 POLD1 RPA4 RPA2 | DNA repair |
| GO:0043596 | 1.53150866514e-06 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | nuclear replication fork |
| REAC:R-HSA-110313 | 1.56499405738e-06 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-69306 | 2.03902622062e-06 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | DNA Replication |
| CORUM:244 | 2.66836560606e-06 | 0.3 | RPA1 RPA2 RPA3 | BRAFT complex |
| REAC:R-HSA-5693538 | 2.99664664154e-06 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | Homology Directed Repair |
| GO:0006261 | 3.48487412653e-06 | 0.6 | RPA3 RPAIN RPA1 POLD1 RPA4 RPA2 | DNA-dependent DNA replication |
| REAC:R-HSA-73893 | 3.77064335825e-06 | 0.4 | POLD1 RPA2 RPA1 RPA3 | DNA Damage Bypass |
| GO:0003684 | 3.88827404399e-06 | 0.5 | POLD1 XPC RPA2 RPA1 RPA3 | damaged DNA binding |
| REAC:R-HSA-73894 | 3.90842726551e-06 | 0.6 | XPC RPA2 RPA1 PARP1 POLD1 RPA3 | DNA Repair |
| GO:0032993 | 5.5275506413e-06 | 0.6 | RPA2 RPA1 PARP1 POLD1 RPA4 RPA3 | protein-DNA complex |
| REAC:R-HSA-5693532 | 7.67886065968e-06 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | DNA Double-Strand Break Repair |
| GO:0005662 | 9.28797042186e-06 | 0.4 | RPA1 RPA4 RPA2 RPA3 | DNA replication factor A complex |
| REAC:R-HSA-3371511 | 1.00000521116e-05 | 0.3 | RPA1 RPA2 RPA3 | HSF1 activation |
| REAC:R-HSA-6782210 | 1.33582958345e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.42296493277e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 1.42296493277e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | HDR through Homologous Recombination (HRR) |
| GO:0005657 | 1.54816312267e-05 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | replication fork |
| REAC:R-HSA-110312 | 2.54187883076e-05 | 0.3 | RPA1 RPA2 RPA3 | Translesion synthesis by REV1 |
| REAC:R-HSA-6781827 | 2.98540538601e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0090734 | 3.04219359068e-05 | 0.5 | PARP1 RPA1 RPA4 RPA2 RPA3 | site of DNA damage |
| GO:0006293 | 3.0493905917e-05 | 0.4 | RPA1 PARP1 RPA2 RPA3 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 3.0493905917e-05 | 0.4 | RPA1 PARP1 RPA2 RPA3 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| REAC:R-HSA-5656121 | 3.08547851834e-05 | 0.3 | RPA1 RPA2 RPA3 | Translesion synthesis by POLI |
| REAC:R-HSA-5655862 | 3.08547851834e-05 | 0.3 | RPA1 RPA2 RPA3 | Translesion synthesis by POLK |
| REAC:R-HSA-157579 | 3.47871152382e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Telomere Maintenance |
| REAC:R-HSA-69002 | 4.22814532204e-05 | 0.4 | RPA1 RPA4 RPA2 RPA3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-110320 | 4.39370578466e-05 | 0.3 | RPA1 RPA2 RPA3 | Translesion Synthesis by POLH |
| GO:0006297 | 4.50876096325e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | nucleotide-excision repair, DNA gap filling |
| GO:0006259 | 5.36366470765e-05 | 0.8 | XPC RPA3 RPAIN RPA1 PARP1 POLD1 RPA4 RPA2 | DNA metabolic process |
| GO:0006974 | 5.42393960193e-05 | 0.8 | XPC RPA3 RPAIN RPA1 PARP1 POLD1 RPA4 RPA2 | cellular response to DNA damage stimulus |
| REAC:R-HSA-6804756 | 5.57023092537e-05 | 0.4 | SSRP1 RPA1 RPA2 RPA3 | Regulation of TP53 Activity through Phosphorylation |
| GO:0006310 | 6.33875503629e-05 | 0.6 | RPA3 RPAIN RPA1 PARP1 RPA4 RPA2 | DNA recombination |
| GO:0006260 | 6.91869360711e-05 | 0.6 | RPA3 RPAIN RPA1 POLD1 RPA4 RPA2 | DNA replication |
| GO:0032201 | 8.9245265137e-05 | 0.4 | POLD1 RPA2 RPA1 RPA3 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 0.000111078314608 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Chromosome Maintenance |
| GO:0003697 | 0.00011662858759 | 0.5 | RPA1 RPA4 RPA2 XPC RPA3 | single-stranded DNA binding |
| REAC:R-HSA-69239 | 0.000158541722492 | 0.4 | POLD1 RPA2 RPA1 RPA3 | Synthesis of DNA |
| REAC:R-HSA-69206 | 0.000233764083353 | 0.4 | RPA1 RPA4 RPA2 RPA3 | G1/S Transition |
| REAC:R-HSA-5693567 | 0.000233764083353 | 0.4 | POLD1 RPA2 RPA1 RPA3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-6783310 | 0.000295097020196 | 0.3 | RPA1 RPA2 RPA3 | Fanconi Anemia Pathway |
| GO:0042769 | 0.000298674788131 | 0.4 | POLD1 RPA2 RPA1 RPA3 | DNA damage response, detection of DNA damage |
| CORUM:5231 | 0.000301566439547 | 0.2 | RPA1 RPA2 | 53BP1-containing complex |
| REAC:R-HSA-5685938 | 0.000321810414277 | 0.3 | RPA1 RPA2 RPA3 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 0.00035008185877 | 0.3 | RPA1 RPA2 RPA3 | Activation of ATR in response to replication stress |
| GO:0006284 | 0.000374033579713 | 0.4 | POLD1 RPA2 RPA1 RPA3 | base-excision repair |
| REAC:R-HSA-5693616 | 0.000379954732889 | 0.3 | RPA1 RPA2 RPA3 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-453279 | 0.000382153388735 | 0.4 | RPA1 RPA4 RPA2 RPA3 | Mitotic G1-G1/S phases |
| GO:0000724 | 0.000414093131115 | 0.5 | PARP1 RPA1 RPA4 RPA2 RPA3 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.000414093131115 | 0.5 | PARP1 RPA1 RPA4 RPA2 RPA3 | recombinational repair |
| GO:0019985 | 0.000462790237267 | 0.4 | POLD1 RPA2 RPA1 RPA3 | translesion synthesis |
| REAC:R-HSA-5693579 | 0.000479614787766 | 0.3 | RPA1 RPA2 RPA3 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5633007 | 0.000496940800765 | 0.4 | SSRP1 RPA1 RPA2 RPA3 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 0.000522666381847 | 0.4 | POLD1 RPA2 RPA1 RPA3 | S Phase |
| GO:0090305 | 0.000527624411971 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | nucleic acid phosphodiester bond hydrolysis |
| WP:WP45 | 0.000528977866642 | 0.3 | RPA1 RPA2 RPA3 | G1 to S cell cycle control |
| GO:0000781 | 0.000799374810829 | 0.5 | PARP1 POLD1 RPA4 RPA2 RPA1 | chromosome, telomeric region |
| GO:0000731 | 0.000824753618342 | 0.4 | POLD1 RPA2 RPA1 RPA3 | DNA synthesis involved in DNA repair |
| WP:WP531 | 0.000909494331361 | 0.2 | POLD1 RPA1 | DNA Mismatch Repair |
| WP:WP4016 | 0.00100802793413 | 0.3 | RPA1 RPA2 PARP1 | DNA IR-damage and cellular response via ATR |
| GO:0006301 | 0.00116245674185 | 0.4 | POLD1 RPA2 RPA1 RPA3 | postreplication repair |
| GO:0000723 | 0.00117253659511 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | telomere maintenance |
| GO:0033260 | 0.00136562237441 | 0.4 | POLD1 RPA2 RPA1 RPA3 | nuclear DNA replication |
| WP:WP2446 | 0.00140000217968 | 0.3 | RPA1 RPA2 RPA3 | Retinoblastoma Gene in Cancer |
| WP:WP186 | 0.00166561537104 | 0.2 | POLD1 RPA1 | Homologous recombination |
| GO:0035861 | 0.00171872239287 | 0.4 | PARP1 RPA4 RPA2 RPA3 | site of double-strand break |
| GO:0032200 | 0.001779797023 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | telomere organization |
| GO:0044786 | 0.0018503338385 | 0.4 | POLD1 RPA2 RPA1 RPA3 | cell cycle DNA replication |
| REAC:R-HSA-3371453 | 0.00194866452029 | 0.3 | RPA1 RPA2 RPA3 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-69278 | 0.00223411282221 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | Cell Cycle, Mitotic |
| CORUM:1098 | 0.00234548715066 | 0.2 | POLD1 RPA1 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-3108214 | 0.00254441551168 | 0.3 | RPA1 PARP1 XPC | SUMOylation of DNA damage response and repair proteins |
| GO:0065004 | 0.00373493901659 | 0.5 | RPA1 PARP1 RPA2 XPC RPA3 | protein-DNA complex assembly |
| CORUM:1111 | 0.0040837116275 | 0.2 | POLD1 RPA1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 0.0040837116275 | 0.2 | POLD1 RPA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-912446 | 0.00437532228124 | 0.3 | RPA1 RPA2 RPA3 | Meiotic recombination |
| REAC:R-HSA-3371556 | 0.00437532228124 | 0.3 | RPA1 RPA2 RPA3 | Cellular response to heat stress |
| GO:0003677 | 0.00504500200194 | 0.8 | XPC RPA2 RPA1 PARP1 SSRP1 POLD1 RPA4 RPA3 | DNA binding |
| REAC:R-HSA-1640170 | 0.00536344984968 | 0.5 | POLD1 RPA4 RPA2 RPA1 RPA3 | Cell Cycle |
| GO:0006283 | 0.00545324499353 | 0.4 | POLD1 RPA2 RPA1 RPA3 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-69473 | 0.00591902969631 | 0.3 | RPA1 RPA2 RPA3 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.0065036589814 | 0.3 | RPA1 RPA2 RPA3 | Processing of DNA double-strand break ends |
| KEGG:03410 | 0.00957194146723 | 0.2 | POLD1 PARP1 | Base excision repair |
| GO:0006302 | 0.00973448831007 | 0.5 | PARP1 RPA1 RPA4 RPA2 RPA3 | double-strand break repair |
| REAC:R-HSA-1500620 | 0.0105434097806 | 0.3 | RPA1 RPA2 RPA3 | Meiosis |
| GO:0071824 | 0.0113085018911 | 0.5 | RPA1 PARP1 RPA2 XPC RPA3 | protein-DNA complex subunit organization |
| REAC:R-HSA-3700989 | 0.0115134084843 | 0.4 | SSRP1 RPA1 RPA2 RPA3 | Transcriptional Regulation by TP53 |
| GO:0042276 | 0.0123497091753 | 0.3 | RPA1 RPA2 RPA3 | error-prone translesion synthesis |
| GO:0070987 | 0.0123497091753 | 0.3 | RPA1 RPA2 RPA3 | error-free translesion synthesis |
| REAC:R-HSA-1474165 | 0.014550106919 | 0.3 | RPA1 RPA2 RPA3 | Reproduction |
| GO:0044454 | 0.0181227164942 | 0.7 | RPA2 RPA1 PARP1 SSRP1 POLD1 RPA4 RPA3 | nuclear chromosome part |
| GO:0000228 | 0.0217407747409 | 0.7 | RPA2 RPA1 PARP1 SSRP1 POLD1 RPA4 RPA3 | nuclear chromosome |
| GO:0098687 | 0.0233146434038 | 0.5 | PARP1 POLD1 RPA4 RPA2 RPA1 | chromosomal region |
| GO:0033554 | 0.0269380657501 | 0.8 | XPC RPA3 RPAIN RPA1 PARP1 POLD1 RPA4 RPA2 | cellular response to stress |
| GO:0060249 | 0.0273820182452 | 0.5 | POLD1 PARP1 RPA2 RPA1 RPA3 | anatomical structure homeostasis |
| REAC:R-HSA-3108232 | 0.0322269756455 | 0.3 | RPA1 PARP1 XPC | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-69481 | 0.0328048670167 | 0.3 | RPA1 RPA2 RPA3 | G2/M Checkpoints |
| REAC:R-HSA-2990846 | 0.0357959362763 | 0.3 | RPA1 PARP1 XPC | SUMOylation |
| GO:0000784 | 0.0378914716756 | 0.4 | POLD1 PARP1 RPA2 RPA1 | nuclear chromosome, telomeric region |
| HPA:014010_12 | 0.0388602233948 | 0.4 | RPA1 XPC RPA2 PARP1 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA3 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPA3 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RPA2 | RPAIN | 0.304 | 0.499 | bioplex (RPA2,RPAIN) bioplex_WMM |
| RPA3 | POLD1 | 0.263 | 0.482 | youn_WMM gupta_WMM fraction |
| RPA3 | TOM1L2 | 0.251 | 0.474 | bioplex_WMM fraction |
| RPA2 | XPC | 0.171 | 0.43 | bioplex (RPA2,XPC) bioplex_WMM |
| PARP1 | RPA2 | 0.165 | 0.42 | bioplex (RPA2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | RPA4 | 0.128 | 0.399 | bioplex (RPA4) bioplex_WMM |
| PARP1 | XPC | 0.112 | 0.381 | bioplex (XPC) bioplex_WMM gupta_WMM |
| PARP1 | RPA1 | 0.104 | 0.368 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPA1 | RPA4 | 0.1 | 0.361 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA3 | 0.1 | 0.36 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SSRP1 | XPC | 0.069 | 0.348 | bioplex (SSRP1,XPC) bioplex_WMM gupta_WMM |
| PARP1 | SSRP1 | 0.066 | 0.35 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPA1 | SSRP1 | 0.054 | 0.303 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPA1 | XPC | 0.048 | 0.294 | bioplex (XPC) bioplex_WMM gupta_WMM |
| RPA3 | RPAIN | 0.041 | 0.27 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | RPAIN | 0.034 | 0.257 | bioplex (RPAIN) bioplex_WMM |
| RPA2 | SSRP1 | 0.03 | 0.235 | bioplex (RPA2,SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | SSRP1 | 0.025 | 0.213 | bioplex (SSRP1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPA3 | XPC | 0.024 | 0.211 | bioplex (XPC) bioplex_WMM |
| POLD1 | SSRP1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RPAIN | XPC | 0.007 | 0.003 | bioplex_WMM WMM_only |
| POLD1 | RPA1 | 0.007 | 0.01 | youn_WMM gupta_WMM WMM_only |
| RPAIN | SSRP1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RPA2 | POLD1 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| PARP1 | TOM1L2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PARP1 | POLD1 | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| POLD1 | TOM1L2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| TOM1L2 | SSRP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| TOM1L2 | XPC | 0.007 | 0.001 | bioplex_WMM WMM_only |
| RPA2 | RPA4 | 0.006 | 0.004 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPA4 | 0.005 | 0.013 | bioplex (RPA4) bioplex_WMM |
| RPA4 | XPC | 0.004 | 0.013 | bioplex (RPA4) bioplex_WMM |
| PARP1 | RPAIN | 0.0 | 0.017 | bioplex (RPAIN) bioplex_WMM |
| RPA1 | TOM1L2 | 0.0 | 0.008 | bioplex_WMM fraction |
| RPA2 | TOM1L2 | 0.0 | 0.002 | bioplex_WMM fraction |
| RPA4 | SSRP1 | 0.0 | 0.001 | bioplex (RPA4) bioplex_WMM |
Images
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Complex HuMAP2_00586 has an average edge precision of 0.246 which is ranked 5430 out of all 6965 complexes.
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