hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00595
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLX4 | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) | UniProt NCBI |
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | UniProt NCBI |
| ERCC1 | DNA excision repair protein ERCC-1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070522 | 9.08185760231e-08 | 1.0 | ERCC4 ERCC1 SLX4 | ERCC4-ERCC1 complex |
| KEGG:03460 | 5.54053458493e-07 | 1.0 | ERCC4 ERCC1 SLX4 | Fanconi anemia pathway |
| REAC:R-HSA-6783310 | 2.94261178253e-06 | 1.0 | ERCC4 ERCC1 SLX4 | Fanconi Anemia Pathway |
| CORUM:368 | 1.00675659188e-05 | 0.666666666667 | ERCC4 ERCC1 | ERCC1-ERCC4-MSH2 complex |
| CORUM:531 | 1.00675659188e-05 | 0.666666666667 | ERCC4 ERCC1 | XPA-ERCC1-ERCC4 complex |
| CORUM:2220 | 1.00675659188e-05 | 0.666666666667 | ERCC4 ERCC1 | RAD52-ERCC4-ERCC1 complex |
| GO:0000109 | 1.49850650438e-05 | 1.0 | ERCC4 ERCC1 SLX4 | nucleotide-excision repair complex |
| REAC:R-HSA-5693567 | 0.000160847790881 | 1.0 | ERCC4 ERCC1 SLX4 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000184352717389 | 1.0 | ERCC4 ERCC1 SLX4 | Homology Directed Repair |
| REAC:R-HSA-5693532 | 0.000324502864875 | 1.0 | ERCC4 ERCC1 SLX4 | DNA Double-Strand Break Repair |
| HP:0002818 | 0.000397654774179 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the radius |
| KEGG:03420 | 0.000422858026176 | 0.666666666667 | ERCC4 ERCC1 | Nucleotide excision repair |
| HP:0040072 | 0.000486030746017 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of forearm bone |
| GO:1990391 | 0.000495506150782 | 1.0 | ERCC4 ERCC1 SLX4 | DNA repair complex |
| HP:0002973 | 0.000503387778576 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the forearm |
| GO:0032205 | 0.000594407580071 | 1.0 | ERCC4 ERCC1 SLX4 | negative regulation of telomere maintenance |
| GO:0004520 | 0.000594407580071 | 1.0 | ERCC4 ERCC1 SLX4 | endodeoxyribonuclease activity |
| HP:0002827 | 0.000596393717035 | 1.0 | ERCC4 ERCC1 SLX4 | Hip dislocation |
| HP:0200007 | 0.000711200862423 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal size of the palpebral fissures |
| HP:0000568 | 0.000767920921454 | 1.0 | ERCC4 ERCC1 SLX4 | Microphthalmia |
| HP:0030311 | 0.000996974273967 | 1.0 | ERCC4 ERCC1 SLX4 | Lower extremity joint dislocation |
| HP:0100887 | 0.00103909509851 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of globe size |
| HP:0001384 | 0.00123534395034 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the hip joint |
| HP:0005262 | 0.00135057313499 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the synovia |
| GO:1905764 | 0.00135247023414 | 0.666666666667 | ERCC4 ERCC1 | regulation of protection from non-homologous end joining at telomere |
| GO:1905765 | 0.00135247023414 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of protection from non-homologous end joining at telomere |
| GO:0061819 | 0.00135247023414 | 0.666666666667 | ERCC4 ERCC1 | telomeric DNA-containing double minutes formation |
| GO:1990599 | 0.00135247023414 | 0.666666666667 | ERCC4 ERCC1 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| GO:0036297 | 0.0015707980909 | 1.0 | ERCC4 ERCC1 SLX4 | interstrand cross-link repair |
| HP:0001172 | 0.00171879794186 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal thumb morphology |
| HP:0005522 | 0.00185475275658 | 0.666666666667 | ERCC4 SLX4 | Pyridoxine-responsive sideroblastic anemia |
| GO:0004536 | 0.00200709053011 | 1.0 | ERCC4 ERCC1 SLX4 | deoxyribonuclease activity |
| HP:0010469 | 0.00204013662007 | 0.666666666667 | ERCC4 SLX4 | Absent testis |
| HP:0009777 | 0.00204013662007 | 0.666666666667 | ERCC4 SLX4 | Absent thumb |
| HP:0010293 | 0.00204013662007 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the uvula |
| HP:0001373 | 0.00231432739846 | 1.0 | ERCC4 ERCC1 SLX4 | Joint dislocation |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | ERCC4 ERCC1 SLX4 | DNA Repair |
| HP:0000135 | 0.00253976225398 | 1.0 | ERCC4 ERCC1 SLX4 | Hypogonadism |
| HP:0100867 | 0.00264917192674 | 0.666666666667 | ERCC4 SLX4 | Duodenal stenosis |
| HP:0012848 | 0.00264917192674 | 0.666666666667 | ERCC4 SLX4 | Small intestinal stenosis |
| HP:0100587 | 0.00264917192674 | 0.666666666667 | ERCC4 SLX4 | Abnormality of the preputium |
| HP:0100760 | 0.00286980764378 | 0.666666666667 | ERCC4 SLX4 | Clubbing of toes |
| HP:0008056 | 0.00330290006376 | 1.0 | ERCC4 ERCC1 SLX4 | Aplasia/Hypoplasia affecting the eye |
| HP:0040070 | 0.00342752570631 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal upper limb bone morphology |
| HP:0200005 | 0.00358457001899 | 0.666666666667 | ERCC4 SLX4 | Abnormal shape of the palpebral fissure |
| HP:0007874 | 0.00358457001899 | 0.666666666667 | ERCC4 SLX4 | Almond-shaped palpebral fissure |
| GO:1904506 | 0.00405722906526 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of telomere maintenance in response to DNA damage |
| GO:1904505 | 0.00405722906526 | 0.666666666667 | ERCC4 ERCC1 | regulation of telomere maintenance in response to DNA damage |
| GO:0000110 | 0.00405722906526 | 0.666666666667 | ERCC4 ERCC1 | nucleotide-excision repair factor 1 complex |
| HP:0001924 | 0.00410511241748 | 0.666666666667 | ERCC4 SLX4 | Sideroblastic anemia |
| REAC:R-HSA-5685938 | 0.00421167999129 | 0.666666666667 | ERCC4 ERCC1 | HDR through Single Strand Annealing (SSA) |
| HP:0003272 | 0.0046930416058 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the hip bone |
| GO:0061982 | 0.00497140885151 | 1.0 | ERCC4 ERCC1 SLX4 | meiosis I cell cycle process |
| REAC:R-HSA-5696400 | 0.00548064029679 | 0.666666666667 | ERCC4 ERCC1 | Dual Incision in GG-NER |
| HP:0001511 | 0.00573405695328 | 1.0 | ERCC4 ERCC1 SLX4 | Intrauterine growth retardation |
| REAC:R-HSA-5696395 | 0.00603484671946 | 0.666666666667 | ERCC4 ERCC1 | Formation of Incision Complex in GG-NER |
| HP:0003220 | 0.00620427636329 | 0.666666666667 | ERCC4 SLX4 | Abnormality of chromosome stability |
| HP:0000813 | 0.00620427636329 | 0.666666666667 | ERCC4 SLX4 | Bicornuate uterus |
| GO:0032204 | 0.00638454589443 | 1.0 | ERCC4 ERCC1 SLX4 | regulation of telomere maintenance |
| HP:0009380 | 0.0068832170429 | 0.666666666667 | ERCC4 SLX4 | Aplasia of the fingers |
| HP:0002644 | 0.00738203065189 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of pelvic girdle bone morphology |
| HP:0000080 | 0.00808721315129 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of reproductive system physiology |
| GO:1904431 | 0.00811409485621 | 0.666666666667 | SLX4 ERCC1 | positive regulation of t-circle formation |
| HP:0001199 | 0.00834660940556 | 0.666666666667 | ERCC4 SLX4 | Triphalangeal thumb |
| HP:0100026 | 0.00873443203011 | 0.666666666667 | ERCC4 SLX4 | Arteriovenous malformation |
| HP:0100491 | 0.00938046670593 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of lower limb joint |
| HP:0000072 | 0.0103735850487 | 0.666666666667 | ERCC4 SLX4 | Hydroureter |
| HP:0003022 | 0.0108053329976 | 0.666666666667 | ERCC4 SLX4 | Hypoplasia of the ulna |
| HP:0040071 | 0.0108053329976 | 0.666666666667 | ERCC4 SLX4 | Abnormal morphology of ulna |
| GO:0004519 | 0.0110330947082 | 1.0 | ERCC4 ERCC1 SLX4 | endonuclease activity |
| GO:0000726 | 0.0110330947082 | 1.0 | ERCC4 ERCC1 SLX4 | non-recombinational repair |
| HP:0001780 | 0.0112167292753 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of toe |
| HP:0011314 | 0.0118541652721 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of long bone morphology |
| HP:0007565 | 0.0121532611158 | 0.666666666667 | ERCC4 SLX4 | Multiple cafe-au-lait spots |
| GO:0051053 | 0.0125706532002 | 1.0 | ERCC4 ERCC1 SLX4 | negative regulation of DNA metabolic process |
| HP:0005344 | 0.0126201279551 | 0.666666666667 | ERCC4 SLX4 | Abnormal carotid artery morphology |
| HP:0002246 | 0.0126201279551 | 0.666666666667 | ERCC4 SLX4 | Abnormality of the duodenum |
| HP:0005918 | 0.012893006316 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal finger phalanx morphology |
| HP:0012041 | 0.0130957715491 | 0.666666666667 | ERCC4 SLX4 | Decreased fertility in males |
| HP:0002860 | 0.0130957715491 | 0.666666666667 | ERCC4 SLX4 | Squamous cell carcinoma |
| HP:0040069 | 0.0131232337806 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal lower limb bone morphology |
| HP:0006495 | 0.0135801907106 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the ulna |
| HP:0002245 | 0.0135801907106 | 0.666666666667 | ERCC4 SLX4 | Meckel diverticulum |
| REAC:R-HSA-6782135 | 0.0138871493871 | 0.666666666667 | ERCC4 ERCC1 | Dual incision in TC-NER |
| HP:0008373 | 0.0139908331347 | 1.0 | ERCC4 ERCC1 SLX4 | Puberty and gonadal disorders |
| HP:0001549 | 0.0145753509873 | 0.666666666667 | ERCC4 SLX4 | Abnormal ileum morphology |
| HP:0000347 | 0.0154916190073 | 1.0 | ERCC4 ERCC1 SLX4 | Micrognathia |
| HP:0009118 | 0.0157517346871 | 1.0 | ERCC4 ERCC1 SLX4 | Aplasia/Hypoplasia of the mandible |
| HP:0009116 | 0.0165495188933 | 1.0 | ERCC4 ERCC1 SLX4 | Aplasia/Hypoplasia involving bones of the skull |
| HP:0002863 | 0.0166709261154 | 0.666666666667 | ERCC4 SLX4 | Myelodysplasia |
| GO:0006289 | 0.0170248502613 | 1.0 | ERCC4 ERCC1 SLX4 | nucleotide-excision repair |
| HP:0001347 | 0.0171883112328 | 1.0 | ERCC4 ERCC1 SLX4 | Hyperreflexia |
| HP:0000518 | 0.017467035817 | 1.0 | ERCC4 ERCC1 SLX4 | Cataract |
| HP:0008050 | 0.0175606092232 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the palpebral fissures |
| HP:0002575 | 0.017771321972 | 0.666666666667 | ERCC4 SLX4 | Tracheoesophageal fistula |
| HP:0000517 | 0.0191035562841 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the lens |
| HP:0009821 | 0.0194876494112 | 0.666666666667 | ERCC4 SLX4 | Forearm undergrowth |
| REAC:R-HSA-6781827 | 0.0200378707185 | 0.666666666667 | ERCC4 ERCC1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:1903046 | 0.0201449224406 | 1.0 | ERCC4 ERCC1 SLX4 | meiotic cell cycle process |
| HP:0008572 | 0.0225234057432 | 0.666666666667 | ERCC4 SLX4 | External ear malformation |
| HP:0009122 | 0.0232373370987 | 1.0 | ERCC4 ERCC1 SLX4 | Aplasia/hypoplasia affecting bones of the axial skeleton |
| REAC:R-HSA-5696399 | 0.0232544758505 | 0.666666666667 | ERCC4 ERCC1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HP:0009824 | 0.0237990042853 | 0.666666666667 | ERCC4 SLX4 | Upper limb undergrowth |
| HP:0000027 | 0.0237990042853 | 0.666666666667 | ERCC4 SLX4 | Azoospermia |
| HP:0012745 | 0.0237990042853 | 0.666666666667 | ERCC4 SLX4 | Short palpebral fissure |
| GO:0000784 | 0.0242409310378 | 1.0 | ERCC4 ERCC1 SLX4 | nuclear chromosome, telomeric region |
| HP:0000992 | 0.0244499336669 | 0.666666666667 | ERCC4 ERCC1 | Cutaneous photosensitivity |
| HP:0006501 | 0.0251096148725 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the radius |
| HP:0000010 | 0.0257780467151 | 0.666666666667 | ERCC4 SLX4 | Recurrent urinary tract infections |
| GO:2001251 | 0.0261539335231 | 1.0 | ERCC4 ERCC1 SLX4 | negative regulation of chromosome organization |
| GO:1904429 | 0.0283955176165 | 0.666666666667 | SLX4 ERCC1 | regulation of t-circle formation |
| GO:1904354 | 0.0283955176165 | 0.666666666667 | ERCC4 ERCC1 | negative regulation of telomere capping |
| HP:0040073 | 0.028539256711 | 0.666666666667 | ERCC4 SLX4 | Abnormal forearm bone morphology |
| HP:0008669 | 0.0292514239306 | 0.666666666667 | ERCC4 SLX4 | Abnormal spermatogenesis |
| HP:0000277 | 0.0308333096044 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the mandible |
| HP:0100886 | 0.0323585280482 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of globe location |
| GO:0051321 | 0.033252767518 | 1.0 | ERCC4 ERCC1 SLX4 | meiotic cell cycle |
| HP:0006503 | 0.0344813463748 | 0.666666666667 | ERCC4 SLX4 | Aplasia/hypoplasia involving forearm bones |
| HP:0000290 | 0.0351100068041 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the forehead |
| HP:0009601 | 0.0352634284647 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the thumb |
| HP:0002683 | 0.0355582148779 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormality of the calvaria |
| HP:0030791 | 0.0358591294675 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal jaw morphology |
| HP:0000957 | 0.0360542445711 | 0.666666666667 | ERCC4 SLX4 | Cafe-au-lait spot |
| HP:0000581 | 0.0368537935068 | 0.666666666667 | SLX4 ERCC1 | Blepharophimosis |
| HP:0000483 | 0.0368537935068 | 0.666666666667 | ERCC4 SLX4 | Astigmatism |
| HP:0000453 | 0.0376620740847 | 0.666666666667 | ERCC4 SLX4 | Choanal atresia |
| HP:0001562 | 0.0393048254184 | 0.666666666667 | ERCC4 SLX4 | Oligohydramnios |
| GO:0000781 | 0.0397775372938 | 1.0 | ERCC4 ERCC1 SLX4 | chromosome, telomeric region |
| REAC:R-HSA-5696398 | 0.0399448421955 | 0.666666666667 | ERCC4 ERCC1 | Nucleotide Excision Repair |
| HP:0008055 | 0.0401392937999 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia affecting the uvea |
| HP:0008053 | 0.0401392937999 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia of the iris |
| HP:0025028 | 0.0409824890748 | 0.666666666667 | ERCC4 SLX4 | Abnormality of enteric nervous system morphology |
| HP:0012331 | 0.0409824890748 | 0.666666666667 | ERCC4 SLX4 | Abnormal autonomic nervous system morphology |
| HP:0004362 | 0.0409824890748 | 0.666666666667 | ERCC4 SLX4 | Abnormality of enteric ganglion morphology |
| HP:0031105 | 0.0409824890748 | 0.666666666667 | ERCC4 SLX4 | Abnormal uterus morphology |
| HP:0002251 | 0.0409824890748 | 0.666666666667 | ERCC4 SLX4 | Aganglionic megacolon |
| HP:0000415 | 0.041834410056 | 0.666666666667 | ERCC4 SLX4 | Abnormality of the choanae |
| HP:0025633 | 0.0426950555564 | 0.666666666667 | ERCC4 SLX4 | Abnormal ureter morphology |
| HP:0000639 | 0.04291596551 | 1.0 | ERCC4 ERCC1 SLX4 | Nystagmus |
| HP:0008062 | 0.0435644243888 | 0.666666666667 | ERCC4 SLX4 | Aplasia/Hypoplasia affecting the anterior segment of the eye |
| HP:0010161 | 0.0435644243888 | 0.666666666667 | ERCC4 SLX4 | Abnormality of the phalanges of the toes |
| HP:0000505 | 0.0446392984448 | 1.0 | ERCC4 ERCC1 SLX4 | Visual impairment |
| HP:0012547 | 0.0446392984448 | 1.0 | ERCC4 ERCC1 SLX4 | Abnormal involuntary eye movements |
| HP:0002650 | 0.0451651492781 | 1.0 | ERCC4 ERCC1 SLX4 | Scoliosis |
| HP:0000324 | 0.0462248590062 | 0.666666666667 | ERCC4 SLX4 | Facial asymmetry |
| HP:0001646 | 0.0462248590062 | 0.666666666667 | ERCC4 SLX4 | Abnormal aortic valve morphology |
| HP:0001217 | 0.0471291092948 | 0.666666666667 | ERCC4 SLX4 | Clubbing |
| HP:0001053 | 0.0480420769795 | 0.666666666667 | ERCC4 SLX4 | Hypopigmented skin patches |
| GO:0031848 | 0.0486736709081 | 0.666666666667 | ERCC4 ERCC1 | protection from non-homologous end joining at telomere |
| GO:0000014 | 0.0486736709081 | 0.666666666667 | ERCC4 ERCC1 | single-stranded DNA endodeoxyribonuclease activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERCC4 | ERCC1 | 1.0 | 0.949 | bioplex (ERCC1) bioplex_WMM youn_WMM Malo fraction |
| SLX4 | ERCC1 | 0.997 | 0.93 | bioplex (ERCC1) bioplex_WMM |
| ERCC4 | SLX4 | 0.009 | 0.109 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00595 has an average edge precision of 0.663 which is ranked 1577 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLX4 | HuMAP2_00595 HuMAP2_04070 HuMAP2_05771 |
| ERCC4 | HuMAP2_00595 HuMAP2_00777 HuMAP2_02823 HuMAP2_03411 HuMAP2_04070 HuMAP2_04705 HuMAP2_05771 |
| ERCC1 | HuMAP2_00595 HuMAP2_04070 HuMAP2_05771 |