hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00596
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ELOC | Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) | UniProt NCBI |
| ELOB | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7576 | 5.02777038712e-06 | 1.0 | ELOC ELOB | VHL-ElonginB-ElonginC complex |
| CORUM:6738 | 5.02777038712e-06 | 1.0 | ELOC ELOB | PRAME-ElonginBC ubiquitin ligase |
| CORUM:5270 | 5.02777038712e-06 | 1.0 | ELOC ELOB | VHL-TCEB1-TCEB2 complex |
| CORUM:622 | 1.00555407742e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) |
| CORUM:6485 | 1.00555407742e-05 | 1.0 | ELOC ELOB | HIF1alpha-VHL-ElonginB-ElonginC complex |
| CORUM:6268 | 1.00555407742e-05 | 1.0 | ELOC ELOB | Cullin-RING E3 ubiquitin ligase complex |
| CORUM:5267 | 1.00555407742e-05 | 1.0 | ELOC ELOB | VHL-VDU1-TCEB1-TCEB2 complex |
| CORUM:211 | 1.00555407742e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) |
| WP:WP3300 | 1.04322772881e-05 | 1.0 | ELOC ELOB | Dual hijack model of Vif in HIV infection |
| CORUM:205 | 1.67592346237e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) |
| CORUM:207 | 1.67592346237e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:208 | 1.67592346237e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:214 | 1.67592346237e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) |
| CORUM:209 | 1.67592346237e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:210 | 1.67592346237e-05 | 1.0 | ELOC ELOB | Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:7556 | 3.51943927099e-05 | 1.0 | ELOC ELOB | PRAME complex |
| WP:WP4241 | 0.000162072879297 | 1.0 | ELOC ELOB | Type 2 papillary renal cell carcinoma |
| KEGG:05211 | 0.000284937903697 | 1.0 | ELOC ELOB | Renal cell carcinoma |
| KEGG:04066 | 0.000722192843471 | 1.0 | ELOC ELOB | HIF-1 signaling pathway |
| REAC:R-HSA-167238 | 0.000831258037338 | 1.0 | ELOC ELOB | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 0.000831258037338 | 1.0 | ELOC ELOB | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 0.000940193062392 | 1.0 | ELOC ELOB | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 0.000940193062392 | 1.0 | ELOC ELOB | HIV elongation arrest and recovery |
| KEGG:04120 | 0.00122335090758 | 1.0 | ELOC ELOB | Ubiquitin mediated proteolysis |
| GO:0070449 | 0.00135247023414 | 1.0 | ELOC ELOB | elongin complex |
| REAC:R-HSA-167169 | 0.00158542359541 | 1.0 | ELOC ELOB | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 0.00158542359541 | 1.0 | ELOC ELOB | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 0.00158542359541 | 1.0 | ELOC ELOB | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167152 | 0.00173458078356 | 1.0 | ELOC ELOB | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-180585 | 0.00230942253115 | 1.0 | ELOC ELOB | Vif-mediated degradation of APOBEC3G |
| REAC:R-HSA-75955 | 0.00286750504412 | 1.0 | ELOC ELOB | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.00286750504412 | 1.0 | ELOC ELOB | Formation of RNA Pol II elongation complex |
| KEGG:05170 | 0.00287432751701 | 1.0 | ELOC ELOB | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-6796648 | 0.00316917126735 | 1.0 | ELOC ELOB | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-1234176 | 0.00348592080174 | 1.0 | ELOC ELOB | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-167172 | 0.004164669804 | 1.0 | ELOC ELOB | Transcription of the HIV genome |
| REAC:R-HSA-1234174 | 0.00452666927187 | 1.0 | ELOC ELOB | Cellular response to hypoxia |
| REAC:R-HSA-674695 | 0.00556574181855 | 1.0 | ELOC ELOB | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-162909 | 0.0123699910758 | 1.0 | ELOC ELOB | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.0147112561527 | 1.0 | ELOC ELOB | Late Phase of HIV Life Cycle |
| KEGG:05200 | 0.0157394270613 | 1.0 | ELOC ELOB | Pathways in cancer |
| REAC:R-HSA-162587 | 0.0177396498492 | 1.0 | ELOC ELOB | HIV Life Cycle |
| REAC:R-HSA-9010553 | 0.0235098543302 | 1.0 | ELOC ELOB | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-376176 | 0.0378389999335 | 1.0 | ELOC ELOB | Signaling by ROBO receptors |
| REAC:R-HSA-8951664 | 0.0411120784555 | 1.0 | ELOC ELOB | Neddylation |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | ELOC ELOB | HIV Infection |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELOC | ELOB | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (ELOC) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00596 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ELOC | HuMAP2_00596 HuMAP2_04294 HuMAP2_05478 HuMAP2_05583 HuMAP2_05603 |
| ELOB | HuMAP2_00596 HuMAP2_04294 HuMAP2_05583 |