hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00604
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CEBPB | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | UniProt NCBI |
| RASSF7 | Ras association domain-containing protein 7 (HRAS1-related cluster protein 1) | UniProt NCBI |
| TP53BP2 | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | UniProt NCBI |
| PPP1R13B | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | UniProt NCBI |
| RASSF8 | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | UniProt NCBI |
| SPARC | SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-139915 | 0.000797179114843 | 0.333333333333 | TP53BP2 PPP1R13B | Activation of PUMA and translocation to mitochondria |
| REAC:R-HSA-6803211 | 0.000996295422965 | 0.333333333333 | TP53BP2 PPP1R13B | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-6804759 | 0.00172598429993 | 0.333333333333 | TP53BP2 PPP1R13B | Regulation of TP53 Activity through Association with Co-factors |
| REAC:R-HSA-6803205 | 0.00172598429993 | 0.333333333333 | TP53BP2 PPP1R13B | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-6803204 | 0.00419905151199 | 0.333333333333 | TP53BP2 PPP1R13B | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| REAC:R-HSA-114452 | 0.00959640616298 | 0.333333333333 | TP53BP2 PPP1R13B | Activation of BH3-only proteins |
| REAC:R-HSA-5633008 | 0.0171765331493 | 0.333333333333 | TP53BP2 PPP1R13B | TP53 Regulates Transcription of Cell Death Genes |
| WP:WP615 | 0.021546686463 | 0.333333333333 | CEBPB SPARC | Senescence and Autophagy in Cancer |
| REAC:R-HSA-109606 | 0.0269276420577 | 0.333333333333 | TP53BP2 PPP1R13B | Intrinsic Pathway for Apoptosis |
| HPA:035020_03 | 0.0276474923479 | 0.666666666667 | SPARC TP53BP2 CEBPB RASSF8 | placenta; trophoblastic cells[Uncertain,High] |
| HPA:008010_02 | 0.047442251818 | 0.666666666667 | SPARC TP53BP2 CEBPB RASSF8 | cerebral cortex; endothelial cells[Uncertain,Medium] |
| CORUM:644 | 0.0499726005494 | 0.166666666667 | PPP1R13B | ASPP1-SAM68 complex |
| CORUM:6068 | 0.0499726005494 | 0.166666666667 | CEBPB | ESR1-CEBPB complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TP53BP2 | RASSF8 | 1.0 | 0.949 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM hein (RASSF8) gupta_WMM boldt_WMM |
| RASSF8 | PPP1R13B | 0.983 | 0.899 | bioplex (RASSF8) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RASSF7 | TP53BP2 | 0.978 | 0.894 | hein_WMM bioplex (RASSF7) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RASSF7 | PPP1R13B | 0.475 | 0.609 | bioplex (RASSF7) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CEBPB | RASSF7 | 0.126 | 0.4 | bioplex (RASSF7) bioplex_WMM |
| RASSF7 | SPARC | 0.043 | 0.268 | bioplex (RASSF7) bioplex_WMM |
| TP53BP2 | PPP1R13B | 0.02 | 0.186 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RASSF7 | RASSF8 | 0.014 | 0.138 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CEBPB | SPARC | 0.009 | 0.095 | bioplex_WMM WMM_only |
| PPP1R13B | SPARC | 0.008 | 0.096 | bioplex_WMM WMM_only |
| TP53BP2 | SPARC | 0.008 | 0.09 | bioplex_WMM WMM_only |
| CEBPB | PPP1R13B | 0.008 | 0.067 | bioplex_WMM WMM_only |
| CEBPB | TP53BP2 | 0.008 | 0.065 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00604 has an average edge precision of 0.366 which is ranked 3686 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CEBPB | HuMAP2_00604 HuMAP2_05899 |
| RASSF7 | HuMAP2_00604 HuMAP2_02376 HuMAP2_04686 HuMAP2_05899 |
| TP53BP2 | HuMAP2_00604 HuMAP2_01276 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 HuMAP2_04686 |
| PPP1R13B | HuMAP2_00604 HuMAP2_02149 HuMAP2_02376 HuMAP2_05899 |
| RASSF8 | HuMAP2_00604 HuMAP2_01053 HuMAP2_01276 HuMAP2_02149 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 |
| SPARC | HuMAP2_00604 HuMAP2_00809 HuMAP2_02186 HuMAP2_02630 |