hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00605
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | UniProt NCBI |
| PRPF4 | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | UniProt NCBI |
| PRPF31 | U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31) | UniProt NCBI |
| SART1 | U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 2.052638918e-07 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | Spliceosome |
| GO:0097526 | 6.68560358851e-07 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | spliceosomal tri-snRNP complex |
| GO:0046540 | 6.68560358851e-07 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | U4/U6 x U5 tri-snRNP complex |
| CORUM:351 | 6.95120006013e-07 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | Spliceosome |
| GO:0015030 | 1.61120484949e-06 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | Cajal body |
| REAC:R-HSA-72163 | 3.66683425084e-06 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.37825325788e-06 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | mRNA Splicing |
| GO:0071005 | 5.61829777936e-06 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | U2-type precatalytic spliceosome |
| GO:0071011 | 6.09645078186e-06 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | precatalytic spliceosome |
| GO:0097525 | 9.63649068965e-06 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | spliceosomal snRNP complex |
| REAC:R-HSA-72203 | 1.12324610099e-05 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0030532 | 1.45315820527e-05 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 2.80701671762e-05 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | Sm-like protein family complex |
| GO:0005684 | 6.52012849586e-05 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | U2-type spliceosomal complex |
| HP:0007675 | 0.000181431813171 | 0.75 | PRPF4 PRPF3 PRPF31 | Progressive night blindness |
| HP:0000563 | 0.000333559712077 | 0.75 | PRPF4 PRPF3 PRPF31 | Keratoconus |
| HP:0100692 | 0.000369216596452 | 0.75 | PRPF4 PRPF3 PRPF31 | Increased corneal curvature |
| HP:0100689 | 0.0004073240164 | 0.75 | PRPF4 PRPF3 PRPF31 | Decreased corneal thickness |
| HP:0011486 | 0.000420585039486 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of corneal thickness |
| GO:0005681 | 0.000657808747052 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | spliceosomal complex |
| HP:0000987 | 0.000673456927273 | 0.75 | PRPF4 PRPF3 PRPF31 | Atypical scarring of skin |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | Metabolism of RNA |
| HP:0000842 | 0.00076934008846 | 0.75 | PRPF4 PRPF3 PRPF31 | Hyperinsulinemia |
| HP:0040214 | 0.000831010499476 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal insulin level |
| HP:0040215 | 0.000831010499476 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal circulating insulin level |
| HP:0100699 | 0.00101134633775 | 0.75 | PRPF4 PRPF3 PRPF31 | Scarring |
| HP:0005978 | 0.00124335446085 | 0.75 | PRPF4 PRPF3 PRPF31 | Type II diabetes mellitus |
| HP:0000510 | 0.00138633858335 | 0.75 | PRPF4 PRPF3 PRPF31 | Rod-cone dystrophy |
| HP:0000512 | 0.00163717999905 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal electroretinogram |
| HP:0000662 | 0.00184392276965 | 0.75 | PRPF4 PRPF3 PRPF31 | Nyctalopia |
| HP:0008046 | 0.00214561105026 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal retinal vascular morphology |
| HP:0000613 | 0.00289196481854 | 0.75 | PRPF4 PRPF3 PRPF31 | Photophobia |
| GO:0000387 | 0.00305917975424 | 0.75 | SART1 PRPF3 PRPF31 | spliceosomal snRNP assembly |
| HP:0100691 | 0.00319166660732 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of the curvature of the cornea |
| HP:0030453 | 0.00324353975762 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal visual electrophysiology |
| HP:0000602 | 0.00433834919234 | 0.75 | PRPF4 PRPF3 PRPF31 | Ophthalmoplegia |
| HP:0000618 | 0.00543109559899 | 0.75 | PRPF4 PRPF3 PRPF31 | Blindness |
| HP:0000597 | 0.00604005240459 | 0.75 | PRPF4 PRPF3 PRPF31 | Ophthalmoparesis |
| HP:0000556 | 0.00694904725796 | 0.75 | PRPF4 PRPF3 PRPF31 | Retinal dystrophy |
| GO:0016607 | 0.00713971525321 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | nuclear speck |
| HP:0000501 | 0.00775694691432 | 0.75 | PRPF4 PRPF3 PRPF31 | Glaucoma |
| HP:0008047 | 0.00813515731085 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of the vasculature of the eye |
| HP:0000405 | 0.00862487853069 | 0.75 | PRPF4 PRPF3 PRPF31 | Conductive hearing impairment |
| HP:0011452 | 0.00892789465924 | 0.75 | PRPF4 PRPF3 PRPF31 | Functional abnormality of the middle ear |
| GO:0000377 | 0.00944788787297 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.00944788787297 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00981835447646 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | RNA splicing, via transesterification reactions |
| HP:0007703 | 0.00998881995999 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of retinal pigmentation |
| HP:0000135 | 0.012868880828 | 0.75 | PRPF4 PRPF3 PRPF31 | Hypogonadism |
| WP:WP411 | 0.0128777248997 | 0.5 | PRPF4 PRPF3 | mRNA Processing |
| HP:0003117 | 0.0135309297604 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal circulating hormone level |
| HP:0001513 | 0.0144951843387 | 0.75 | PRPF4 PRPF3 PRPF31 | Obesity |
| HP:0000819 | 0.0146365452656 | 0.75 | PRPF4 PRPF3 PRPF31 | Diabetes mellitus |
| HP:0001952 | 0.0158004749793 | 0.75 | PRPF4 PRPF3 PRPF31 | Glucose intolerance |
| GO:0008380 | 0.0187431053955 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | RNA splicing |
| HP:0004324 | 0.0196567858552 | 0.75 | PRPF4 PRPF3 PRPF31 | Increased body weight |
| HP:0008736 | 0.0201786179727 | 0.75 | PRPF4 PRPF3 PRPF31 | Hypoplasia of penis |
| HP:0007663 | 0.0236980209279 | 0.75 | PRPF4 PRPF3 PRPF31 | Reduced visual acuity |
| GO:0006397 | 0.0251226492241 | 1.0 | PRPF4 PRPF31 PRPF3 SART1 | mRNA processing |
| HP:0000431 | 0.027386484137 | 0.75 | PRPF4 PRPF3 PRPF31 | Wide nasal bridge |
| HP:0000370 | 0.0278183273244 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of the middle ear |
| HP:0000050 | 0.0307356499029 | 0.75 | PRPF4 PRPF3 PRPF31 | Hypoplastic male external genitalia |
| HP:0003241 | 0.0353531558248 | 0.75 | PRPF4 PRPF3 PRPF31 | External genital hypoplasia |
| GO:0030621 | 0.0405595771497 | 0.5 | PRPF4 PRPF31 | U4 snRNA binding |
| HP:0000080 | 0.0406864321028 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of reproductive system physiology |
| HP:0000463 | 0.0418131938681 | 0.75 | PRPF4 PRPF3 PRPF31 | Anteverted nares |
| HP:0005288 | 0.0453169017901 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormality of the nares |
| HP:0011014 | 0.0477573380446 | 0.75 | PRPF4 PRPF3 PRPF31 | Abnormal glucose homeostasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRPF3 | SART1 | 1.0 | 0.949 | hein_WMM bioplex (PRPF3) bioplex_WMM youn_WMM hein (PRPF3,SART1) Malo gupta_WMM fraction treiber_WMM |
| PRPF3 | PRPF31 | 1.0 | 0.949 | hein_WMM bioplex (PRPF3,PRPF31) bioplex_WMM boldt (PRPF31) youn_WMM hein (PRPF3) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PRPF4 | PRPF3 | 1.0 | 0.949 | hein_WMM bioplex (PRPF3,PRPF4) bioplex_WMM Guru boldt youn_WMM hein (PRPF3,PRPF4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PRPF4 | SART1 | 1.0 | 0.949 | hein_WMM bioplex (PRPF4) bioplex_WMM Guru youn_WMM hein (PRPF4,SART1) Malo gupta_WMM fraction treiber_WMM |
| PRPF4 | PRPF31 | 1.0 | 0.949 | hein_WMM bioplex (PRPF31,PRPF4) bioplex_WMM boldt (PRPF31) youn_WMM hein (PRPF4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SART1 | PRPF31 | 1.0 | 0.949 | hein_WMM bioplex (PRPF31) bioplex_WMM youn_WMM hein (SART1) Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_00605 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
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