hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00608
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPL10 | 60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM) | UniProt NCBI |
| RPS17 | 40S ribosomal protein S17 (Small ribosomal subunit protein eS17) | UniProt NCBI |
| RPL35 | 60S ribosomal protein L35 (Large ribosomal subunit protein uL29) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP477 | 6.82717373445e-06 | 1.0 | RPL35 RPS17 RPL10 | Cytoplasmic Ribosomal Proteins |
| KEGG:03010 | 1.07586932974e-05 | 1.0 | RPL35 RPS17 RPL10 | Ribosome |
| CORUM:306 | 1.78209483209e-05 | 1.0 | RPL35 RPS17 RPL10 | Ribosome, cytoplasmic |
| CORUM:3055 | 3.86936712237e-05 | 1.0 | RPL35 RPS17 RPL10 | Nop56p-associated pre-rRNA complex |
| REAC:R-HSA-192823 | 4.93369666261e-05 | 1.0 | RPL35 RPS17 RPL10 | Viral mRNA Translation |
| REAC:R-HSA-156902 | 4.93369666261e-05 | 1.0 | RPL35 RPS17 RPL10 | Peptide chain elongation |
| REAC:R-HSA-72764 | 5.64603800841e-05 | 1.0 | RPL35 RPS17 RPL10 | Eukaryotic Translation Termination |
| REAC:R-HSA-2408557 | 5.64603800841e-05 | 1.0 | RPL35 RPS17 RPL10 | Selenocysteine synthesis |
| REAC:R-HSA-156842 | 5.64603800841e-05 | 1.0 | RPL35 RPS17 RPL10 | Eukaryotic Translation Elongation |
| REAC:R-HSA-975956 | 6.02657683388e-05 | 1.0 | RPL35 RPS17 RPL10 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-72689 | 7.26998205096e-05 | 1.0 | RPL35 RPS17 RPL10 | Formation of a pool of free 40S subunits |
| REAC:R-HSA-156827 | 9.70320053332e-05 | 1.0 | RPL35 RPS17 RPL10 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-1799339 | 9.97273388147e-05 | 1.0 | RPL35 RPS17 RPL10 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-72706 | 9.97273388147e-05 | 1.0 | RPL35 RPS17 RPL10 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-975957 | 0.000105266822355 | 1.0 | RPL35 RPS17 RPL10 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.000105266822355 | 1.0 | RPL35 RPS17 RPL10 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-2408522 | 0.000108111871608 | 1.0 | RPL35 RPS17 RPL10 | Selenoamino acid metabolism |
| REAC:R-HSA-72613 | 0.000120004609098 | 1.0 | RPL35 RPS17 RPL10 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.000120004609098 | 1.0 | RPL35 RPS17 RPL10 | Cap-dependent Translation Initiation |
| REAC:R-HSA-168273 | 0.000160847790881 | 1.0 | RPL35 RPS17 RPL10 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-168255 | 0.000192668461855 | 1.0 | RPL35 RPS17 RPL10 | Influenza Life Cycle |
| REAC:R-HSA-168254 | 0.000238014806299 | 1.0 | RPL35 RPS17 RPL10 | Influenza Infection |
| REAC:R-HSA-9010553 | 0.000348984315873 | 1.0 | RPL35 RPS17 RPL10 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-6791226 | 0.00043699470959 | 1.0 | RPL35 RPS17 RPL10 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.000513949964862 | 1.0 | RPL35 RPS17 RPL10 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.000599447561444 | 1.0 | RPL35 RPS17 RPL10 | rRNA processing |
| REAC:R-HSA-376176 | 0.00071395360032 | 1.0 | RPL35 RPS17 RPL10 | Signaling by ROBO receptors |
| REAC:R-HSA-72766 | 0.00180867442135 | 1.0 | RPL35 RPS17 RPL10 | Translation |
| REAC:R-HSA-71291 | 0.00315795701338 | 1.0 | RPL35 RPS17 RPL10 | Metabolism of amino acids and derivatives |
| REAC:R-HSA-5663205 | 0.00340936351327 | 1.0 | RPL35 RPS17 RPL10 | Infectious disease |
| CORUM:308 | 0.0034666239215 | 0.666666666667 | RPL35 RPL10 | 60S ribosomal subunit, cytoplasmic |
| HP:0001972 | 0.00953643840968 | 0.666666666667 | RPL35 RPS17 | Macrocytic anemia |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | RPL35 RPS17 RPL10 | Axon guidance |
| GO:0006614 | 0.0106693663112 | 1.0 | RPL35 RPS17 RPL10 | SRP-dependent cotranslational protein targeting to membrane |
| GO:0006613 | 0.0129761581422 | 1.0 | RPL35 RPS17 RPL10 | cotranslational protein targeting to membrane |
| GO:0022626 | 0.0142448028307 | 1.0 | RPL35 RPS17 RPL10 | cytosolic ribosome |
| GO:0045047 | 0.0165384259681 | 1.0 | RPL35 RPS17 RPL10 | protein targeting to ER |
| GO:0072599 | 0.0185411572066 | 1.0 | RPL35 RPS17 RPL10 | establishment of protein localization to endoplasmic reticulum |
| REAC:R-HSA-8953854 | 0.0206735000409 | 1.0 | RPL35 RPS17 RPL10 | Metabolism of RNA |
| GO:0000184 | 0.0212638981157 | 1.0 | RPL35 RPS17 RPL10 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| HP:0011793 | 0.027043635032 | 1.0 | RPL35 RPS17 RPL10 | Neoplasm by anatomical site |
| HP:0002488 | 0.0292514239306 | 0.666666666667 | RPL35 RPS17 | Acute leukemia |
| HP:0002664 | 0.0308333096044 | 1.0 | RPL35 RPS17 RPL10 | Neoplasm |
| GO:0070972 | 0.033252767518 | 1.0 | RPL35 RPS17 RPL10 | protein localization to endoplasmic reticulum |
| HP:0000159 | 0.0373891909751 | 1.0 | RPL35 RPS17 RPL10 | Abnormal lip morphology |
| GO:0003735 | 0.0406485782564 | 1.0 | RPL35 RPS17 RPL10 | structural constituent of ribosome |
| HP:0000457 | 0.0462248590062 | 0.666666666667 | RPL35 RPS17 | Depressed nasal ridge |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPL10 | RPL35 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (RPL10,RPL35) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL10 | RPS17 | 0.848 | 0.79 | hein_WMM bioplex_WMM boldt hein (RPL10) gupta_WMM boldt_WMM treiber_WMM |
| RPS17 | RPL35 | 0.84 | 0.784 | hein_WMM bioplex_WMM boldt youn_WMM hein (RPL35) gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00608 has an average edge precision of 0.841 which is ranked 810 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPL10 | HuMAP2_00215 HuMAP2_00608 HuMAP2_01734 HuMAP2_02207 HuMAP2_04712 HuMAP2_05622 |
| RPS17 | HuMAP2_00215 HuMAP2_00608 HuMAP2_00945 |
| RPL35 | HuMAP2_00608 HuMAP2_00945 HuMAP2_02207 HuMAP2_05622 HuMAP2_06948 |