hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00612

Confidence: Medium High

Genename	Protein Name	Links
BAK1	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	UniProt NCBI
BCL2L2	Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W)	UniProt NCBI
MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)	UniProt NCBI
BAX	Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)	UniProt NCBI
BBC3	Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis)	UniProt NCBI
PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP254	9.11448099954e-11	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	Apoptosis
WP:WP1772	1.55474272356e-10	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	Apoptosis Modulation and Signaling
KEGG:04210	1.82977457169e-09	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	Apoptosis
KEGG:04215	3.1791735226e-09	0.8	BAK1 BAX PMAIP1 BBC3	Apoptosis - multiple species
WP:WP3614	3.69152214444e-09	0.8	BAK1 MCL1 PMAIP1 BAX	Photodynamic therapy-induced HIF-1 survival signaling
REAC:R-HSA-109606	8.38983891617e-08	0.8	BAK1 BAX PMAIP1 BBC3	Intrinsic Pathway for Apoptosis
WP:WP4216	8.74750175162e-08	0.8	BAK1 BAX PMAIP1 BBC3	Chromosomal and microsatellite instability in colorectal cancer
KEGG:01524	1.1907721613e-07	0.8	BAK1 BAX PMAIP1 BBC3	Platinum drug resistance
KEGG:05210	2.02335642541e-07	0.8	BAK1 BAX PMAIP1 BBC3	Colorectal cancer
WP:WP710	4.13226609885e-07	0.8	BAK1 BAX PMAIP1 BBC3	DNA Damage Response (only ATM dependent)
WP:WP1742	4.56811629309e-07	0.6	BBC3 BAX PMAIP1	TP53 Network
WP:WP3872	7.65599689843e-07	0.6	BAK1 MCL1 BAX	Regulation of Apoptosis by Parathyroid Hormone-related Protein
GO:2001235	9.13147455327e-07	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	positive regulation of apoptotic signaling pathway
WP:WP3982	1.03402263863e-06	0.6	BBC3 BAX PMAIP1	miRNA regulation of p53 pathway in prostate cancer
GO:0005741	1.69808838788e-06	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	mitochondrial outer membrane
GO:0031968	2.53392137774e-06	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	organelle outer membrane
GO:0019867	2.63290268156e-06	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	outer membrane
REAC:R-HSA-6803204	3.09448976434e-06	0.6	BBC3 BAX PMAIP1	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
GO:1905898	4.983554895e-06	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of response to endoplasmic reticulum stress
GO:1901030	4.983554895e-06	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
CORUM:5823	6.70868171695e-06	0.4	BAK1 MCL1	MCL1-BAK1 complex
GO:2001244	1.00139303444e-05	0.8	BBC3 MCL1 PMAIP1 BAX	positive regulation of intrinsic apoptotic signaling pathway
GO:1901028	1.00139303444e-05	0.8	BAK1 BAX PMAIP1 BBC3	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
WP:WP3611	1.08600279875e-05	0.6	BAK1 MCL1 BAX	Photodynamic therapy-induced AP-1 survival signaling.
REAC:R-HSA-109581	1.18707037161e-05	0.8	BAK1 BAX PMAIP1 BBC3	Apoptosis
REAC:R-HSA-5357801	1.27422309093e-05	0.8	BAK1 BAX PMAIP1 BBC3	Programmed Cell Death
GO:0070059	1.50217389985e-05	0.8	BAK1 BAX PMAIP1 BBC3	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001836	1.50217389985e-05	0.8	BAK1 BAX PMAIP1 BBC3	release of cytochrome c from mitochondria
GO:0097136	1.81582264982e-05	0.6	BAK1 MCL1 BAX	Bcl-2 family protein complex
GO:0097193	2.07718623633e-05	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	intrinsic apoptotic signaling pathway
GO:0097345	2.36783333556e-05	0.8	BAK1 BAX PMAIP1 BBC3	mitochondrial outer membrane permeabilization
REAC:R-HSA-5633008	2.67648652633e-05	0.6	BBC3 BAX PMAIP1	TP53 Regulates Transcription of Cell Death Genes
GO:1902110	2.802206198e-05	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of mitochondrial membrane permeability involved in apoptotic process
WP:WP707	3.20197280625e-05	0.6	BBC3 BAX PMAIP1	DNA Damage Response
GO:1902686	3.29372797631e-05	0.8	BAK1 BAX PMAIP1 BBC3	mitochondrial outer membrane permeabilization involved in programmed cell death
GO:0035794	3.56241182538e-05	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of mitochondrial membrane permeability
GO:1902108	3.56241182538e-05	0.8	BAK1 BAX PMAIP1 BBC3	regulation of mitochondrial membrane permeability involved in apoptotic process
KEGG:04115	3.58157342459e-05	0.6	BBC3 BAX PMAIP1	p53 signaling pathway
WP:WP1530	3.65771562028e-05	0.6	BBC3 BAX PMAIP1	miRNA Regulation of DNA Damage Response
GO:1905710	3.84719751497e-05	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of membrane permeability
GO:1903896	5.0832789986e-05	0.6	BAK1 BAX BBC3	positive regulation of IRE1-mediated unfolded protein response
GO:0046902	5.1601378618e-05	0.8	BAK1 BAX PMAIP1 BBC3	regulation of mitochondrial membrane permeability
GO:2001233	6.27558258349e-05	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	regulation of apoptotic signaling pathway
GO:0090559	8.23131966602e-05	0.8	BAK1 BAX PMAIP1 BBC3	regulation of membrane permeability
GO:1905897	0.000111444253056	0.8	BAK1 BAX PMAIP1 BBC3	regulation of response to endoplasmic reticulum stress
REAC:R-HSA-111457	0.000134922692372	0.4	BAK1 BAX	Release of apoptotic factors from the mitochondria
GO:1903894	0.000199619769136	0.6	BAK1 BAX BBC3	regulation of IRE1-mediated unfolded protein response
KEGG:05200	0.000217862252065	0.8	BAK1 BAX PMAIP1 BBC3	Pathways in cancer
GO:0032461	0.000259479548289	0.6	BBC3 BAX PMAIP1	positive regulation of protein oligomerization
GO:1900103	0.000259479548289	0.6	BAK1 BAX BBC3	positive regulation of endoplasmic reticulum unfolded protein response
WP:WP4396	0.000278228795868	0.6	BAK1 BAX BBC3	Nonalcoholic fatty liver disease
KEGG:05162	0.000291563855438	0.6	BAK1 BAX BBC3	Measles
GO:0008637	0.000324482580121	0.8	BAK1 BAX PMAIP1 BBC3	apoptotic mitochondrial changes
GO:0010822	0.000438392708191	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of mitochondrion organization
REAC:R-HSA-111453	0.000485460775426	0.4	BBC3 PMAIP1	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
GO:0097190	0.000519871906443	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	apoptotic signaling pathway
WP:WP2507	0.000569740286986	0.4	BAK1 BAX	Nanomaterial induced apoptosis
GO:0007006	0.000674764960334	0.8	BAK1 BAX PMAIP1 BBC3	mitochondrial membrane organization
GO:2001242	0.000700189954213	0.8	BBC3 MCL1 PMAIP1 BAX	regulation of intrinsic apoptotic signaling pathway
MIRNA:hsa-miR-125b-5p	0.000720079712331	0.8	BAK1 MCL1 PMAIP1 BBC3	hsa-miR-125b-5p
GO:0043065	0.000734680304842	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	positive regulation of apoptotic process
GO:2001056	0.000780783958982	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of cysteine-type endopeptidase activity
GO:0043068	0.000790881181884	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	positive regulation of programmed cell death
KEGG:05203	0.000925161775741	0.6	BAK1 BAX PMAIP1	Viral carcinogenesis
GO:0032469	0.00103355958129	0.6	BAK1 BAX BBC3	endoplasmic reticulum calcium ion homeostasis
GO:0043525	0.00103355958129	0.6	BBC3 MCL1 BAX	positive regulation of neuron apoptotic process
GO:0010942	0.00120467043863	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	positive regulation of cell death
GO:0010950	0.00133388073681	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of endopeptidase activity
GO:0032459	0.00139593056214	0.6	BBC3 BAX PMAIP1	regulation of protein oligomerization
GO:1900101	0.00139593056214	0.6	BAK1 BAX BBC3	regulation of endoplasmic reticulum unfolded protein response
GO:0090200	0.00139593056214	0.6	BBC3 BAX PMAIP1	positive regulation of release of cytochrome c from mitochondria
GO:0097191	0.0016027516158	0.8	BAK1 MCL1 PMAIP1 BAX	extrinsic apoptotic signaling pathway
REAC:R-HSA-111471	0.00161668141155	0.4	BAK1 BAX	Apoptotic factor-mediated response
GO:0010952	0.0016512304967	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of peptidase activity
GO:0010821	0.00170079952717	0.8	BAK1 BAX PMAIP1 BBC3	regulation of mitochondrion organization
GO:0031966	0.00186999534998	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	mitochondrial membrane
GO:0005740	0.00259545536123	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	mitochondrial envelope
KEGG:05216	0.00284609034939	0.4	BAK1 BAX	Thyroid cancer
WP:WP1971	0.00299893680898	0.4	BBC3 BAX	Integrated Cancer Pathway
GO:0001844	0.00330982532021	0.6	BBC3 BAX PMAIP1	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0080135	0.00386135739029	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	regulation of cellular response to stress
GO:2000116	0.00387118310235	0.8	BAK1 BAX PMAIP1 BBC3	regulation of cysteine-type endopeptidase activity
GO:0097145	0.00450823411379	0.4	BAK1 BAX	BAK complex
GO:0010248	0.00450823411379	0.4	BAK1 BAX	establishment or maintenance of transmembrane electrochemical gradient
WP:WP3959	0.00492385173449	0.4	BAK1 BAX	DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM
GO:0090199	0.00541762673764	0.6	BBC3 BAX PMAIP1	regulation of release of cytochrome c from mitochondria
REAC:R-HSA-114452	0.00584945327803	0.4	BBC3 PMAIP1	Activation of BH3-only proteins
WP:WP4155	0.0062641329336	0.4	BAK1 BAX	Endometrial cancer
KEGG:05217	0.00656425237639	0.4	BAK1 BAX	Basal cell carcinoma
KEGG:05213	0.00680203716674	0.4	BAK1 BAX	Endometrial cancer
GO:0097192	0.00703245670927	0.6	BAK1 MCL1 BAX	extrinsic apoptotic signaling pathway in absence of ligand
GO:0038034	0.00703245670927	0.6	BAK1 MCL1 BAX	signal transduction in absence of ligand
WP:WP4255	0.00799132765459	0.4	BAK1 BAX	Non-small cell lung cancer
KEGG:05218	0.00805388520034	0.4	BAK1 BAX	Melanoma
KEGG:05223	0.00858395707223	0.4	BAK1 BAX	Non-small cell lung cancer
KEGG:05214	0.00969431019543	0.4	BAK1 BAX	Glioma
GO:0051881	0.0103850554114	0.6	BAK1 BAX PMAIP1	regulation of mitochondrial membrane potential
KEGG:05212	0.0105709544625	0.4	BAK1 BAX	Pancreatic cancer
WP:WP4263	0.0112409645576	0.4	BAK1 BAX	Pancreatic adenocarcinoma pathway
KEGG:05220	0.0114851584748	0.4	BAK1 BAX	Chronic myeloid leukemia
GO:1901216	0.0119783897598	0.6	BBC3 MCL1 BAX	positive regulation of neuron death
GO:0051204	0.0119783897598	0.6	BBC3 BAX PMAIP1	protein insertion into mitochondrial membrane
GO:0006839	0.0123084612281	0.8	BAK1 BAX PMAIP1 BBC3	mitochondrial transport
GO:0006974	0.0123166418329	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	cellular response to DNA damage stimulus
WP:WP4658	0.0147251965341	0.4	BAK1 BAX	Small cell lung cancer
GO:0052548	0.0162353670779	0.8	BAK1 BAX PMAIP1 BBC3	regulation of endopeptidase activity
GO:0034976	0.0167850233213	0.8	BAK1 BAX PMAIP1 BBC3	response to endoplasmic reticulum stress
KEGG:05222	0.0177565608839	0.4	BAK1 BAX	Small cell lung cancer
REAC:R-HSA-3700989	0.0182828935298	0.6	BBC3 BAX PMAIP1	Transcriptional Regulation by TP53
GO:0044429	0.0210056852384	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	mitochondrial part
GO:0051205	0.0211681462149	0.6	BBC3 BAX PMAIP1	protein insertion into membrane
GO:0052547	0.0220379383235	0.8	BAK1 BAX PMAIP1 BBC3	regulation of peptidase activity
GO:0045862	0.0227281670195	0.8	BAK1 BAX PMAIP1 BBC3	positive regulation of proteolysis
CORUM:2000	0.0249780992026	0.2	BAX	BAX homo-oligomer complex
CORUM:3492	0.0249780992026	0.2	BAX	BAX homo-oligomer complex
GO:0031967	0.0253087624128	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	organelle envelope
GO:0031975	0.0253087624128	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	envelope
GO:0051434	0.0270421395626	0.4	MCL1 BAX	BH3 domain binding
GO:0051400	0.0270421395626	0.4	MCL1 BAX	BH domain binding
WP:WP4262	0.0314432287467	0.4	BAK1 BAX	Breast cancer pathway
GO:0036498	0.0324949337356	0.6	BAK1 BAX BBC3	IRE1-mediated unfolded protein response
WP:WP1984	0.0337317416567	0.4	BAK1 BAX	Integrated Breast Cancer Pathway
KEGG:05224	0.0353865382697	0.4	BAK1 BAX	Breast cancer
KEGG:05226	0.0359303198923	0.4	BAK1 BAX	Gastric cancer
KEGG:05160	0.038710268063	0.4	BAK1 BAX	Hepatitis C
GO:0042981	0.0430701572404	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	regulation of apoptotic process
KEGG:05164	0.0457961859483	0.4	BAK1 BAX	Influenza A
GO:0043067	0.047236850153	1.0	BBC3 BAK1 MCL1 PMAIP1 BAX	regulation of programmed cell death
MIRNA:hsa-miR-876-3p	0.0482780268961	0.4	BBC3 MCL1	hsa-miR-876-3p
GO:0008630	0.0493791608738	0.6	BAK1 MCL1 BAX	intrinsic apoptotic signaling pathway in response to DNA damage
WP:WP4399	0.0497141369515	0.2	MCL1	MicroRNA network associated with chronic lymphocytic leukemia

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BAK1	MCL1	0.998	0.939	bioplex (MCL1)
MCL1	BBC3	0.628	0.68	bioplex (MCL1)
MCL1	BAX	0.273	0.487	bioplex (MCL1) bioplex_WMM
BCL2L2	BAX	0.258	0.481	bioplex (BCL2L2) bioplex_WMM
MCL1	PMAIP1	0.242	0.468	bioplex (MCL1)
BCL2L2	BBC3	0.193	0.446	bioplex (BCL2L2) bioplex_WMM
BAX	BBC3	0.01	0.098	bioplex_WMM WMM_only
BAK1	BBC3	0.009	0.104	bioplex_WMM WMM_only
BAK1	PMAIP1	0.009	0.095	bioplex_WMM WMM_only
BBC3	PMAIP1	0.008	0.091	bioplex_WMM WMM_only
BAK1	BAX	0.008	0.089	bioplex_WMM WMM_only
BAX	PMAIP1	0.008	0.07	bioplex_WMM WMM_only

Images

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Complex HuMAP2_00612 has an average edge precision of 0.337 which is ranked 4153 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BAK1	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310
BCL2L2	HuMAP2_00267 HuMAP2_00612 HuMAP2_03119 HuMAP2_06564
MCL1	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310 HuMAP2_05402 HuMAP2_06133
BAX	HuMAP2_00283 HuMAP2_00612 HuMAP2_01697 HuMAP2_02045 HuMAP2_06133
BBC3	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_06133 HuMAP2_06564
PMAIP1	HuMAP2_00283 HuMAP2_00612 HuMAP2_04371

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00612