hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00616
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HAGH | Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II) | UniProt NCBI |
| NUDT5 | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | UniProt NCBI |
| PPT1 | Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) | UniProt NCBI |
| PYCR3 | Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) | UniProt NCBI |
| KLHDC10 | Kelch domain-containing protein 10 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 2.33456820519e-06 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | Glutamate and glutamine metabolism |
| GO:0004735 | 1.27120391093e-05 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 1.27120391093e-05 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | L-proline biosynthetic process |
| GO:0006561 | 3.17736949706e-05 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | proline biosynthetic process |
| KEGG:00330 | 5.71082541759e-05 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | Arginine and proline metabolism |
| KEGG:01100 | 0.000138040728497 | 0.857142857143 | PYCR2 PYCR3 PYCR1 HAGH NUDT5 PPT1 | Metabolic pathways |
| KEGG:01230 | 0.000187840964122 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | Biosynthesis of amino acids |
| GO:0006560 | 0.000380900357231 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | proline metabolic process |
| GO:0009084 | 0.00115446662879 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | glutamine family amino acid biosynthetic process |
| WP:WP497 | 0.00210605462929 | 0.285714285714 | PYCR1 PYCR3 | Urea cycle and metabolism of amino groups |
| GO:0016646 | 0.00215539204286 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| GO:0016645 | 0.00727854676446 | 0.428571428571 | PYCR2 PYCR1 PYCR3 | oxidoreductase activity, acting on the CH-NH group of donors |
| WP:WP4290 | 0.00859430044807 | 0.285714285714 | PYCR2 PYCR1 | Metabolic reprogramming in colon cancer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.949 | hein_WMM bioplex (PYCR1,PYCR2) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT5 | PYCR2 | 0.992 | 0.912 | bioplex (PYCR2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NUDT5 | PYCR1 | 0.971 | 0.882 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| PYCR3 | PYCR1 | 0.251 | 0.475 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM boldt_WMM |
| PYCR3 | PYCR2 | 0.11 | 0.379 | bioplex (PYCR2) bioplex_WMM youn_WMM |
| PYCR1 | KLHDC10 | 0.037 | 0.265 | bioplex (PYCR1) bioplex_WMM |
| NUDT5 | HAGH | 0.028 | 0.231 | bioplex (HAGH) bioplex_WMM fraction boldt_WMM |
| HAGH | PPT1 | 0.02 | 0.184 | bioplex_WMM fraction |
| NUDT5 | KLHDC10 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| NUDT5 | PYCR3 | 0.008 | 0.033 | bioplex_WMM youn_WMM WMM_only |
| PYCR2 | KLHDC10 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| PYCR2 | HAGH | 0.007 | 0.003 | bioplex_WMM WMM_only boldt_WMM |
| PYCR1 | HAGH | 0.007 | 0.004 | bioplex_WMM WMM_only boldt_WMM |
| PYCR2 | PPT1 | 0.007 | 0.0 | bioplex_WMM WMM_only treiber_WMM |
| KLHDC10 | PPT1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| PYCR3 | KLHDC10 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PYCR3 | PPT1 | 0.004 | 0.015 | bioplex_WMM WMM_only |
| PYCR1 | PPT1 | 0.003 | 0.011 | bioplex_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_00616 has an average edge precision of 0.248 which is ranked 5410 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HAGH | HuMAP2_00616 HuMAP2_03922 HuMAP2_06328 |
| NUDT5 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_05934 |
| PPT1 | HuMAP2_00616 |
| PYCR3 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_06858 |
| KLHDC10 | HuMAP2_00201 HuMAP2_00369 HuMAP2_00616 HuMAP2_02782 HuMAP2_04537 |
| PYCR1 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_05934 HuMAP2_06951 |
| PYCR2 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_03284 HuMAP2_05934 HuMAP2_06951 |