hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00618
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LZTS2 | Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1) | UniProt NCBI |
| CEP78 | Centrosomal protein of 78 kDa (Cep78) | UniProt NCBI |
| USP54 | Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54) | UniProt NCBI |
| ALMS1 | Alstrom syndrome protein 1 | UniProt NCBI |
| SIPA1L2 | Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380259 | 0.0295837500362 | 0.4 | CEP78 ALMS1 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0295837500362 | 0.4 | CEP78 ALMS1 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.0323002764482 | 0.4 | CEP78 ALMS1 | AURKA Activation by TPX2 |
| REAC:R-HSA-380287 | 0.0411580285567 | 0.4 | CEP78 ALMS1 | Centrosome maturation |
| REAC:R-HSA-380270 | 0.0411580285567 | 0.4 | CEP78 ALMS1 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-2565942 | 0.0465369402216 | 0.4 | CEP78 ALMS1 | Regulation of PLK1 Activity at G2/M Transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SIPA1L2 | LZTS2 | 0.999 | 0.948 | youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM |
| LZTS2 | ALMS1 | 0.047 | 0.292 | youn (LZTS2) bioplex (LZTS2) bioplex_WMM youn_WMM gupta_WMM |
| CEP78 | LZTS2 | 0.044 | 0.274 | hein_WMM youn (LZTS2) bioplex (LZTS2) bioplex_WMM hein (CEP78) |
| USP54 | LZTS2 | 0.042 | 0.269 | youn (LZTS2) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
| SIPA1L2 | USP54 | 0.008 | 0.035 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SIPA1L2 | ALMS1 | 0.007 | 0.011 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| USP54 | ALMS1 | 0.007 | 0.01 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SIPA1L2 | CEP78 | 0.007 | 0.005 | bioplex_WMM youn_WMM WMM_only |
| CEP78 | ALMS1 | 0.006 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CEP78 | USP54 | 0.006 | 0.009 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_00618 has an average edge precision of 0.186 which is ranked 6365 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LZTS2 | HuMAP2_00618 HuMAP2_02173 HuMAP2_03011 HuMAP2_03772 |
| CEP78 | HuMAP2_00618 HuMAP2_03772 HuMAP2_05261 |
| USP54 | HuMAP2_00618 HuMAP2_03772 HuMAP2_06786 |
| ALMS1 | HuMAP2_00618 HuMAP2_01481 HuMAP2_03324 HuMAP2_03772 HuMAP2_04653 |
| SIPA1L2 | HuMAP2_00035 HuMAP2_00618 HuMAP2_02173 HuMAP2_02612 HuMAP2_03011 HuMAP2_03772 |