hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00625

Confidence: Medium

Genename	Protein Name	Links
CDH24	Cadherin-24	UniProt NCBI
CDH2	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	UniProt NCBI
CDH3	Cadherin-3 (Placental cadherin) (P-cadherin)	UniProt NCBI
CTNNA3	Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein)	UniProt NCBI
CDH10	Cadherin-10 (T2-cadherin)	UniProt NCBI
CDH12	Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)	UniProt NCBI
CDH4	Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-418990	2.28496570386e-14	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	Adherens junctions interactions
REAC:R-HSA-421270	5.4436964611e-13	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	Cell-cell junction organization
GO:0016342	1.72259881629e-12	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	catenin complex
GO:0005913	1.06947262656e-11	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cell-cell adherens junction
REAC:R-HSA-446728	1.10273472623e-11	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	Cell junction organization
WP:WP4540	1.23562694719e-11	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	Pathways Regulating Hippo Signaling
GO:0016339	2.55543396121e-11	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
WP:WP4541	3.29197923534e-11	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	Hippo-Merlin Signaling Dysregulation
GO:0044331	3.74460063447e-11	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell-cell adhesion mediated by cadherin
REAC:R-HSA-1500931	1.0988896923e-10	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	Cell-Cell communication
GO:0007156	8.36101257106e-10	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007043	1.53278469178e-08	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell-cell junction assembly
GO:0005911	3.13823106737e-08	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cell-cell junction
GO:0034332	4.39595027341e-08	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	adherens junction organization
GO:0045216	4.91984119721e-08	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell-cell junction organization
GO:0045296	9.47579342923e-08	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cadherin binding
GO:0019897	1.02488965277e-07	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	extrinsic component of plasma membrane
GO:0098742	1.43380219169e-07	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell-cell adhesion via plasma-membrane adhesion molecules
GO:0050839	9.67660645223e-07	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cell adhesion molecule binding
GO:0005912	1.20548211392e-06	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	adherens junction
GO:0034329	1.21231873965e-06	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell junction assembly
GO:0070161	1.4259378893e-06	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	anchoring junction
GO:0098609	2.33928894855e-06	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cell-cell adhesion
GO:0034330	3.26396158778e-06	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell junction organization
GO:0019898	3.44871359841e-06	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	extrinsic component of membrane
GO:0005509	1.32228964186e-05	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	calcium ion binding
GO:0030054	2.15716170853e-05	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cell junction
GO:0007155	0.000114322836824	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	cell adhesion
GO:0022610	0.000119970661969	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	biological adhesion
GO:0098797	0.000120054472817	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	plasma membrane protein complex
GO:0009986	0.000290353513123	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell surface
KEGG:04514	0.000544386754487	0.428571428571	CDH2 CDH4 CDH3	Cell adhesion molecules (CAMs)
GO:0042803	0.0017330443562	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	protein homodimerization activity
GO:0000902	0.00215454474769	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cell morphogenesis
GO:0032989	0.00386206265228	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cellular component morphogenesis
GO:0008092	0.00402753802694	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cytoskeletal protein binding
GO:0046983	0.00667078659164	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	protein dimerization activity
GO:0046872	0.00753308965215	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	metal ion binding
REAC:R-HSA-525793	0.00945016076191	0.285714285714	CDH4 CDH2	Myogenesis
GO:0098796	0.0126459869113	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	membrane protein complex
GO:0043169	0.0127333409276	0.857142857143	CDH4 CDH24 CDH3 CDH12 CDH2 CDH10	cation binding
WP:WP2118	0.0232759452351	0.285714285714	CTNNA3 CDH2	Arrhythmogenic Right Ventricular Cardiomyopathy
KEGG:05412	0.0249705175143	0.285714285714	CTNNA3 CDH2	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
WP:000000	0.0394625231882	1.0	CDH4 CDH24 CDH3 CDH2 CDH12 CTNNA3 CDH10	WIKIPATHWAYS
CORUM:6269	0.0499886427319	0.142857142857	CDH2	DLL1-CTNNB1-CDH2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CTNNA3	CDH4	0.998	0.939	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH3	0.882	0.817	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH12	0.722	0.732	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH24	0.214	0.464	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH2	0.083	0.349	bioplex (CTNNA3) bioplex_WMM
CDH10	CTNNA3	0.068	0.348	bioplex (CTNNA3) bioplex_WMM
CDH10	CDH4	0.009	0.095	bioplex_WMM WMM_only
CDH12	CDH4	0.009	0.095	bioplex_WMM WMM_only
CDH10	CDH12	0.009	0.095	bioplex_WMM WMM_only
CDH12	CDH24	0.008	0.091	bioplex_WMM WMM_only
CDH4	CDH24	0.008	0.091	bioplex_WMM WMM_only
CDH4	CDH3	0.008	0.091	bioplex_WMM WMM_only
CDH10	CDH3	0.008	0.091	bioplex_WMM WMM_only
CDH12	CDH3	0.008	0.091	bioplex_WMM WMM_only
CDH10	CDH24	0.008	0.091	bioplex_WMM WMM_only
CDH3	CDH24	0.008	0.085	bioplex_WMM WMM_only
CDH2	CDH24	0.008	0.022	bioplex_WMM WMM_only
CDH10	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH4	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH12	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH3	CDH2	0.007	0.008	bioplex_WMM WMM_only

Images

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Complex HuMAP2_00625 has an average edge precision of 0.221 which is ranked 5838 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CDH24	HuMAP2_00625 HuMAP2_04278 HuMAP2_04808 HuMAP2_05814
CDH2	HuMAP2_00477 HuMAP2_00625 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022
CDH3	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_05748 HuMAP2_05798 HuMAP2_06022
CTNNA3	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_02274 HuMAP2_04278 HuMAP2_04643 HuMAP2_05168 HuMAP2_06022
CDH10	HuMAP2_00343 HuMAP2_00625 HuMAP2_02943
CDH12	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022
CDH4	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00625