hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00634
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ITGA7 | Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] | UniProt NCBI |
| ITGA6 | Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] | UniProt NCBI |
| TSPAN11 | Tetraspanin-11 (Tspan-11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05412 | 0.0011410864499 | 0.666666666667 | ITGA6 ITGA7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:04512 | 0.00134028141892 | 0.666666666667 | ITGA6 ITGA7 | ECM-receptor interaction |
| KEGG:05410 | 0.00144586300556 | 0.666666666667 | ITGA6 ITGA7 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:05414 | 0.00159284054118 | 0.666666666667 | ITGA6 ITGA7 | Dilated cardiomyopathy (DCM) |
| WP:WP2118 | 0.00224353083145 | 0.666666666667 | ITGA6 ITGA7 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| REAC:R-HSA-3000157 | 0.00290884705451 | 0.666666666667 | ITGA6 ITGA7 | Laminin interactions |
| WP:WP185 | 0.00408673569856 | 0.666666666667 | ITGA6 ITGA7 | Integrin-mediated Cell Adhesion |
| WP:WP4541 | 0.00491871423903 | 0.666666666667 | ITGA6 ITGA7 | Hippo-Merlin Signaling Dysregulation |
| KEGG:04810 | 0.00772384569084 | 0.666666666667 | ITGA6 ITGA7 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.0078896816737 | 0.666666666667 | ITGA6 ITGA7 | Focal adhesion |
| WP:WP306 | 0.0167204021762 | 0.666666666667 | ITGA6 ITGA7 | Focal Adhesion |
| REAC:R-HSA-216083 | 0.0185190091635 | 0.666666666667 | ITGA6 ITGA7 | Integrin cell surface interactions |
| KEGG:04151 | 0.0198175756043 | 0.666666666667 | ITGA6 ITGA7 | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.0214257750703 | 0.666666666667 | ITGA6 ITGA7 | Human papillomavirus infection |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | ITGA6 ITGA7 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP4172 | 0.0388642175144 | 0.666666666667 | ITGA6 ITGA7 | PI3K-Akt Signaling Pathway |
| CORUM:2323 | 0.0499776345577 | 0.333333333333 | ITGA6 | ITGA6-ITGB4 complex |
| CORUM:2397 | 0.0499776345577 | 0.333333333333 | ITGA7 | ITGA7-ITGB1-ITGB1BP3 complex |
| CORUM:2413 | 0.0499776345577 | 0.333333333333 | ITGA6 | ITGA6-ITGB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITGA6 | TSPAN11 | 0.118 | 0.391 | bioplex (TSPAN11) bioplex_WMM |
| TSPAN11 | ITGA7 | 0.026 | 0.217 | bioplex (TSPAN11) bioplex_WMM |
| ITGA6 | ITGA7 | 0.01 | 0.139 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00634 has an average edge precision of 0.249 which is ranked 5392 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ITGA7 | HuMAP2_00634 HuMAP2_01322 |
| ITGA6 | HuMAP2_00016 HuMAP2_00634 HuMAP2_01322 HuMAP2_04065 |
| TSPAN11 | HuMAP2_00016 HuMAP2_00634 HuMAP2_01322 |