hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00635
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1) | UniProt NCBI |
| CDC20 | Cell division cycle protein 20 homolog (p55CDC) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:190 | 1.00555407742e-05 | 1.0 | BUB1B CDC20 | Mitotic checkpoint complex (MCC) |
| WP:WP4240 | 3.39049011863e-05 | 1.0 | BUB1B CDC20 | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| REAC:R-HSA-141405 | 0.000286582912066 | 1.0 | BUB1B CDC20 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| REAC:R-HSA-141430 | 0.000286582912066 | 1.0 | BUB1B CDC20 | Inactivation of APC/C via direct inhibition of the APC/C complex |
| REAC:R-HSA-179409 | 0.000462554875615 | 1.0 | BUB1B CDC20 | APC-Cdc20 mediated degradation of Nek2A |
| KEGG:04110 | 0.00104170846513 | 1.0 | BUB1B CDC20 | Cell cycle |
| KEGG:05166 | 0.00281669798708 | 1.0 | BUB1B CDC20 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-174184 | 0.004164669804 | 1.0 | BUB1B CDC20 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| REAC:R-HSA-179419 | 0.00428366036983 | 1.0 | BUB1B CDC20 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| REAC:R-HSA-176409 | 0.00452666927187 | 1.0 | BUB1B CDC20 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176814 | 0.00465068760809 | 1.0 | BUB1B CDC20 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176408 | 0.00516352018758 | 1.0 | BUB1B CDC20 | Regulation of APC/C activators between G1/S and early anaphase |
| REAC:R-HSA-174143 | 0.00598304676068 | 1.0 | BUB1B CDC20 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-453276 | 0.00598304676068 | 1.0 | BUB1B CDC20 | Regulation of mitotic cell cycle |
| REAC:R-HSA-141444 | 0.0070154156135 | 1.0 | BUB1B CDC20 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0070154156135 | 1.0 | BUB1B CDC20 | Amplification of signal from the kinetochores |
| REAC:R-HSA-69618 | 0.00950416195513 | 1.0 | BUB1B CDC20 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 0.0119660935214 | 1.0 | BUB1B CDC20 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.0147112561527 | 1.0 | BUB1B CDC20 | RHO GTPases Activate Formins |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | BUB1B CDC20 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | BUB1B CDC20 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | BUB1B CDC20 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | BUB1B CDC20 | Mitotic Metaphase and Anaphase |
| HP:0006849 | 0.0497341708567 | 0.5 | BUB1B | Hypodysplasia of the corpus callosum |
| CORUM:2718 | 0.0499173803268 | 0.5 | CDC20 | MAD2-CDC20 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDC20 | BUB1B | 0.82 | 0.773 | hein_WMM bioplex (CDC20) bioplex_WMM youn_WMM hein (BUB1B,CDC20) gupta_WMM |
Images
Click to enlarge
Complex HuMAP2_00635 has an average edge precision of 0.773 which is ranked 1033 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BUB1B | HuMAP2_00635 HuMAP2_03465 HuMAP2_03762 HuMAP2_05264 |
| CDC20 | HuMAP2_00635 HuMAP2_03601 HuMAP2_03762 |