hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00638
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | UniProt NCBI |
| EIF4ENIF1 | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 2.07570829481e-08 | 0.8 | EIF4E EIF4EBP2 EIF4EBP1 EIF4G3 | Translation Factors |
| KEGG:03013 | 2.52925620727e-06 | 0.8 | EIF4E EIF4EBP2 EIF4EBP1 EIF4G3 | RNA transport |
| WP:WP4566 | 1.01678610147e-05 | 0.6 | EIF4E EIF4EBP1 EIF4G3 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0006417 | 6.53381130104e-05 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | regulation of translation |
| GO:0034248 | 0.000147406856078 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | regulation of cellular amide metabolic process |
| WP:WP516 | 0.000509836133129 | 0.4 | EIF4E EIF4EBP1 | Hypertrophy Model |
| WP:WP3879 | 0.000509836133129 | 0.4 | EIF4E EIF4EBP1 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| GO:0045182 | 0.000700189954213 | 0.8 | EIF4E EIF4EBP2 EIF4EBP1 EIF4G3 | translation regulator activity |
| GO:0031369 | 0.00183428165932 | 0.6 | EIF4E EIF4EBP1 EIF4EBP2 | translation initiation factor binding |
| GO:0010608 | 0.0019087106243 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | posttranscriptional regulation of gene expression |
| GO:0006412 | 0.00235530637857 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | translation |
| GO:0043043 | 0.00293652212837 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | peptide biosynthetic process |
| REAC:R-HSA-166208 | 0.0031096034254 | 0.4 | EIF4E EIF4EBP1 | mTORC1-mediated signalling |
| GO:0006413 | 0.00387118310235 | 0.8 | EIF4E EIF4EBP2 EIF4EBP1 EIF4G3 | translational initiation |
| WP:WP585 | 0.00474544100801 | 0.4 | EIF4E EIF4EBP1 | Interferon type I signaling pathways |
| GO:0043604 | 0.00727283691478 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | amide biosynthetic process |
| GO:0006518 | 0.00744517222081 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | peptide metabolic process |
| WP:WP2034 | 0.00893290103597 | 0.4 | EIF4E EIF4EBP1 | Leptin signaling pathway |
| REAC:R-HSA-165159 | 0.00995219083388 | 0.4 | EIF4E EIF4EBP1 | mTOR signalling |
| KEGG:01521 | 0.0114851584748 | 0.4 | EIF4E EIF4EBP1 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 0.0141063112147 | 0.4 | EIF4E EIF4EBP1 | Longevity regulating pathway |
| KEGG:04066 | 0.020974746694 | 0.4 | EIF4E EIF4EBP1 | HIF-1 signaling pathway |
| WP:WP4549 | 0.0215596505176 | 0.4 | EIF4E EIF4EBP2 | Fragile X Syndrome |
| REAC:R-HSA-72662 | 0.0237053784759 | 0.4 | EIF4E EIF4EBP1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| WP:WP3915 | 0.0250517914711 | 0.4 | EIF4E EIF4EBP1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| GO:0043603 | 0.0273795782463 | 1.0 | EIF4E EIF4EBP2 EIF4EBP1 EIF4ENIF1 EIF4G3 | cellular amide metabolic process |
| REAC:R-HSA-1169408 | 0.0295837500362 | 0.4 | EIF4E EIF4G3 | ISG15 antiviral mechanism |
| WP:WP2380 | 0.0301079862712 | 0.4 | EIF4E EIF4EBP1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| KEGG:04910 | 0.0327287628992 | 0.4 | EIF4E EIF4EBP1 | Insulin signaling pathway |
| REAC:R-HSA-1169410 | 0.0361060371214 | 0.4 | EIF4E EIF4G3 | Antiviral mechanism by IFN-stimulated genes |
| WP:WP481 | 0.0385448371419 | 0.4 | EIF4E EIF4EBP1 | Insulin Signaling |
| GO:0006446 | 0.0412952841175 | 0.6 | EIF4G3 EIF4EBP1 EIF4EBP2 | regulation of translational initiation |
| KEGG:04150 | 0.0433693821301 | 0.4 | EIF4E EIF4EBP1 | mTOR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF4E | EIF4G3 | 1.0 | 0.949 | bioplex (EIF4E) bioplex_WMM youn_WMM fraction |
| EIF4ENIF1 | EIF4E | 1.0 | 0.949 | youn (EIF4ENIF1) bioplex (EIF4E) bioplex_WMM youn_WMM |
| EIF4E | EIF4EBP1 | 0.978 | 0.893 | bioplex (EIF4E) bioplex_WMM fraction |
| EIF4E | EIF4EBP2 | 0.716 | 0.729 | bioplex (EIF4E) bioplex_WMM fraction |
| EIF4EBP2 | EIF4EBP1 | 0.103 | 0.366 | bioplex_WMM fraction |
| EIF4ENIF1 | EIF4EBP1 | 0.009 | 0.097 | bioplex_WMM gupta_WMM WMM_only |
| EIF4G3 | EIF4EBP2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| EIF4G3 | EIF4EBP1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| EIF4ENIF1 | EIF4G3 | 0.007 | 0.002 | youn (EIF4ENIF1) bioplex_WMM youn_WMM |
| EIF4ENIF1 | EIF4EBP2 | 0.0 | 0.008 | bioplex_WMM fraction |
Images
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Complex HuMAP2_00638 has an average edge precision of 0.406 which is ranked 3246 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EIF4E | HuMAP2_00638 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719 |
| EIF4G3 | HuMAP2_00638 HuMAP2_03421 HuMAP2_05690 HuMAP2_05719 |
| EIF4ENIF1 | HuMAP2_00038 HuMAP2_00638 HuMAP2_04239 HuMAP2_04647 HuMAP2_04754 HuMAP2_05137 |
| EIF4EBP2 | HuMAP2_00638 HuMAP2_02769 HuMAP2_03226 HuMAP2_04754 HuMAP2_05137 HuMAP2_05719 |
| EIF4EBP1 | HuMAP2_00638 HuMAP2_02769 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719 |