hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00641
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PITX2 | Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin) | UniProt NCBI |
| NKX2-5 | Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E) | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | UniProt NCBI |
| HOXC9 | Homeobox protein Hox-C9 (Homeobox protein Hox-3B) | UniProt NCBI |
| JOSD2 | Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2) | UniProt NCBI |
| AHCYL2 | Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) | UniProt NCBI |
| ZIC2 | Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2525 | 0.00435375672817 | 0.285714285714 | AHCYL2 AHCYL1 | Trans-sulfuration and one carbon metabolism |
| WP:WP1591 | 0.00629697152788 | 0.285714285714 | PITX2 NKX2-5 | Heart Development |
| KEGG:00270 | 0.0101703984163 | 0.285714285714 | AHCYL2 AHCYL1 | Cysteine and methionine metabolism |
| WP:WP4657 | 0.0239551606733 | 0.285714285714 | PITX2 NKX2-5 | 22q11.2 Deletion Syndrome |
| HP:0009800 | 0.0290730325003 | 0.285714285714 | NKX2-5 ZIC2 | Maternal diabetes |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AHCYL2 | AHCYL1 | 0.999 | 0.949 | bioplex (AHCYL2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| JOSD2 | AHCYL2 | 0.175 | 0.434 | bioplex (JOSD2) bioplex_WMM |
| ZIC2 | AHCYL2 | 0.108 | 0.372 | bioplex (AHCYL2) bioplex_WMM |
| PITX2 | AHCYL2 | 0.108 | 0.372 | bioplex (AHCYL2,PITX2) bioplex_WMM youn_WMM |
| JOSD2 | AHCYL1 | 0.064 | 0.347 | bioplex (JOSD2) bioplex_WMM |
| NKX2-5 | AHCYL2 | 0.048 | 0.296 | bioplex (AHCYL2) bioplex_WMM |
| HOXC9 | AHCYL2 | 0.029 | 0.231 | bioplex (AHCYL2,HOXC9) bioplex_WMM |
| ZIC2 | HOXC9 | 0.01 | 0.129 | bioplex_WMM WMM_only |
| ZIC2 | NKX2-5 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| HOXC9 | NKX2-5 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| ZIC2 | PITX2 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| PITX2 | NKX2-5 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| PITX2 | HOXC9 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| HOXC9 | AHCYL1 | 0.007 | 0.004 | bioplex (HOXC9) bioplex_WMM |
| ZIC2 | AHCYL1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| NKX2-5 | AHCYL1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PITX2 | AHCYL1 | 0.0 | 0.013 | bioplex (PITX2) bioplex_WMM |
Images
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Complex HuMAP2_00641 has an average edge precision of 0.203 which is ranked 6136 out of all 6965 complexes.
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