hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00655
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PKLR | Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) | UniProt NCBI |
| PMM1 | Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) | UniProt NCBI |
| PMM2 | Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446205 | 6.69449800487e-05 | 0.666666666667 | PMM2 PMM1 | Synthesis of GDP-mannose |
| KEGG:00051 | 0.000236130222292 | 0.666666666667 | PMM2 PMM1 | Fructose and mannose metabolism |
| KEGG:00520 | 0.000462599152438 | 0.666666666667 | PMM2 PMM1 | Amino sugar and nucleotide sugar metabolism |
| HP:0001790 | 0.000803978270478 | 0.666666666667 | PKLR PMM2 | Nonimmune hydrops fetalis |
| GO:0004615 | 0.00135247023414 | 0.666666666667 | PMM2 PMM1 | phosphomannomutase activity |
| GO:0009298 | 0.00811409485621 | 0.666666666667 | PMM2 PMM1 | GDP-mannose biosynthetic process |
| KEGG:01100 | 0.0105851300972 | 1.0 | PKLR PMM1 PMM2 | Metabolic pathways |
| REAC:R-HSA-446219 | 0.0110397460449 | 0.666666666667 | PMM2 PMM1 | Synthesis of substrates in N-glycan biosythesis |
| HP:0001789 | 0.0161338784795 | 0.666666666667 | PKLR PMM2 | Hydrops fetalis |
| REAC:R-HSA-446193 | 0.0175395775792 | 0.666666666667 | PMM2 PMM1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| GO:0019673 | 0.020283420769 | 0.666666666667 | PMM2 PMM1 | GDP-mannose metabolic process |
| GO:0006013 | 0.0283955176165 | 0.666666666667 | PMM2 PMM1 | mannose metabolic process |
| REAC:R-HSA-4043911 | 0.0498572752401 | 0.333333333333 | PMM2 | Defective PMM2 causes PMM2-CDG (CDG-1a) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PMM2 | PMM1 | 0.995 | 0.923 | bioplex (PMM1) bioplex_WMM |
| PMM2 | PKLR | 0.044 | 0.275 | Guru fraction |
Images
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Complex HuMAP2_00655 has an average edge precision of 0.599 which is ranked 1950 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PKLR | HuMAP2_00655 |
| PMM1 | HuMAP2_00312 HuMAP2_00655 HuMAP2_01034 HuMAP2_02764 HuMAP2_04511 HuMAP2_07014 |
| PMM2 | HuMAP2_00312 HuMAP2_00655 HuMAP2_01034 HuMAP2_04511 |