hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00660
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TRIP12 | E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | UniProt NCBI |
| CD99L2 | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | UniProt NCBI |
| RP9 | Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6710 | 6.70868171695e-06 | 0.4 | CAPN1 CAPNS1 | Calpain 1 |
| REAC:R-HSA-8862803 | 0.00282729215335 | 0.4 | CAPN1 CAPNS1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00282729215335 | 0.4 | CAPN1 CAPNS1 | Neurodegenerative Diseases |
| WP:WP185 | 0.0141122881464 | 0.4 | CAPN1 CAPNS1 | Integrin-mediated Cell Adhesion |
| CORUM:6706 | 0.0499494897235 | 0.2 | CAPN1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CD99L2 | CAPN1 | 0.997 | 0.93 | bioplex (CAPN1) bioplex_WMM |
| CAPNS1 | CAPN1 | 0.992 | 0.912 | hein_WMM bioplex (CAPN1) bioplex_WMM hein (CAPN1) |
| TRIP12 | CAPN1 | 0.527 | 0.634 | bioplex (CAPN1) bioplex_WMM youn_WMM |
| CAPN1 | RP9 | 0.044 | 0.274 | bioplex (CAPN1) bioplex_WMM |
| CD99L2 | RP9 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| TRIP12 | RP9 | 0.008 | 0.084 | bioplex_WMM youn_WMM WMM_only |
| TRIP12 | CD99L2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CAPNS1 | RP9 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| CAPNS1 | CD99L2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
| TRIP12 | CAPNS1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00660 has an average edge precision of 0.309 which is ranked 4466 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TRIP12 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02830 |
| CAPNS1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| CD99L2 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| CAPN1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 HuMAP2_05795 |
| RP9 | HuMAP2_00660 HuMAP2_02830 |