hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00663
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 1.00555407742e-05 | 1.0 | POLA1 POLA2 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-174430 | 4.69258569465e-05 | 1.0 | POLA1 POLA2 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-68952 | 4.69258569465e-05 | 1.0 | POLA1 POLA2 | DNA replication initiation |
| CORUM:1003 | 6.03332446455e-05 | 1.0 | POLA1 POLA2 | RC complex (Replication competent complex) |
| CORUM:1107 | 7.54165558069e-05 | 1.0 | POLA1 POLA2 | DNA synthesome core complex |
| KEGG:03030 | 9.19154528054e-05 | 1.0 | POLA1 POLA2 | DNA replication |
| CORUM:1098 | 0.000130722030065 | 1.0 | POLA1 POLA2 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-113501 | 0.000130722030065 | 1.0 | POLA1 POLA2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69109 | 0.000152509035076 | 1.0 | POLA1 POLA2 | Leading Strand Synthesis |
| REAC:R-HSA-69091 | 0.000152509035076 | 1.0 | POLA1 POLA2 | Polymerase switching |
| REAC:R-HSA-69166 | 0.000152509035076 | 1.0 | POLA1 POLA2 | Removal of the Flap Intermediate |
| REAC:R-HSA-174411 | 0.000152509035076 | 1.0 | POLA1 POLA2 | Polymerase switching on the C-strand of the telomere |
| CORUM:1108 | 0.000175971963549 | 1.0 | POLA1 POLA2 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-69183 | 0.000175971963549 | 1.0 | POLA1 POLA2 | Processive synthesis on the lagging strand |
| CORUM:1099 | 0.000227925590883 | 1.0 | POLA1 POLA2 | DNA synthesome complex (17 subunits) |
| CORUM:1111 | 0.000227925590883 | 1.0 | POLA1 POLA2 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-69186 | 0.000318425457851 | 1.0 | POLA1 POLA2 | Lagging Strand Synthesis |
| WP:WP466 | 0.000320792526609 | 1.0 | POLA1 POLA2 | DNA Replication |
| REAC:R-HSA-113510 | 0.000387138319809 | 1.0 | POLA1 POLA2 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174417 | 0.000462554875615 | 1.0 | POLA1 POLA2 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 0.000729026706133 | 1.0 | POLA1 POLA2 | Extension of Telomeres |
| REAC:R-HSA-69190 | 0.000831258037338 | 1.0 | POLA1 POLA2 | DNA strand elongation |
| REAC:R-HSA-68962 | 0.000884887588134 | 1.0 | POLA1 POLA2 | Activation of the pre-replicative complex |
| WP:WP4022 | 0.00114792308302 | 1.0 | POLA1 POLA2 | Pyrimidine metabolism |
| GO:0005658 | 0.00450823411379 | 1.0 | POLA1 POLA2 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-157579 | 0.00542999201809 | 1.0 | POLA1 POLA2 | Telomere Maintenance |
| REAC:R-HSA-69002 | 0.00598304676068 | 1.0 | POLA1 POLA2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-73886 | 0.0096834857656 | 1.0 | POLA1 POLA2 | Chromosome Maintenance |
| REAC:R-HSA-69239 | 0.0115688996608 | 1.0 | POLA1 POLA2 | Synthesis of DNA |
| REAC:R-HSA-69306 | 0.0131978972662 | 1.0 | POLA1 POLA2 | DNA Replication |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | POLA1 POLA2 | G1/S Transition |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | POLA1 POLA2 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 0.0210512746109 | 1.0 | POLA1 POLA2 | S Phase |
| HP:0007599 | 0.0497341708567 | 0.5 | POLA1 | Generalized reticulate brown pigmentation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLA2 | POLA1 | 0.902 | 0.826 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_00663 has an average edge precision of 0.826 which is ranked 847 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLA1 | HuMAP2_00663 HuMAP2_01177 HuMAP2_01225 HuMAP2_03670 HuMAP2_04366 HuMAP2_06629 |
| POLA2 | HuMAP2_00663 HuMAP2_01177 HuMAP2_01225 HuMAP2_01835 HuMAP2_04366 HuMAP2_06629 |