hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00664
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PUDP | Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase) | UniProt NCBI |
| HSD17B14 | 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1) | UniProt NCBI |
| ITPA | Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p) | UniProt NCBI |
| GLUL | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | UniProt NCBI |
| NIT1 | Deaminated glutathione amidase (dGSH amidase) (EC 3.5.1.128) (Nitrilase homolog 1) | UniProt NCBI |
| NEDD8 | NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8) | UniProt NCBI |
| GCK | Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) | UniProt NCBI |
| PARK7 | Protein/nucleic acid deglycase DJ-1 (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase) (Oncogene DJ1) (Parkinson disease protein 7) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) | UniProt NCBI |
| ACY1 | Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00220 | 0.00313846793702 | 0.222222222222 | GLUL ACY1 | Arginine biosynthesis |
| HP:0002188 | 0.0383405566315 | 0.222222222222 | ACY1 ITPA | Delayed CNS myelination |
| KEGG:01230 | 0.0403966480843 | 0.222222222222 | GLUL ACY1 | Biosynthesis of amino acids |
| REAC:R-HSA-1430728 | 0.0473316214616 | 0.666666666667 | ACY1 ITPA HSD17B14 GCK GLUL PUDP | Metabolism |
| CORUM:5830 | 0.0499262710315 | 0.111111111111 | PARK7 | DJ-1-SNCA complex, high molecular weight complex |
| CORUM:5837 | 0.0499262710315 | 0.111111111111 | PARK7 | PPD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITPA | PARK7 | 0.936 | 0.85 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| NIT1 | PARK7 | 0.901 | 0.825 | bioplex (NIT1) fraction treiber_WMM |
| HSD17B14 | PUDP | 0.345 | 0.534 | fraction |
| ITPA | ACY1 | 0.323 | 0.512 | fraction |
| ITPA | NIT1 | 0.269 | 0.483 | fraction |
| PUDP | PARK7 | 0.212 | 0.462 | bioplex (PUDP) fraction |
| HSD17B14 | ITPA | 0.203 | 0.455 | Guru fraction |
| GLUL | ACY1 | 0.203 | 0.454 | fraction |
| ITPA | GCK | 0.186 | 0.44 | fraction |
| HSD17B14 | PARK7 | 0.161 | 0.418 | Guru fraction |
| HSD17B14 | NIT1 | 0.086 | 0.351 | fraction |
| ITPA | NEDD8 | 0.07 | 0.348 | gupta_WMM fraction |
| NIT1 | ACY1 | 0.068 | 0.348 | fraction |
| PARK7 | ACY1 | 0.063 | 0.348 | bioplex (ACY1) fraction |
| NEDD8 | GCK | 0.053 | 0.3 | fraction |
| NEDD8 | PARK7 | 0.036 | 0.266 | bioplex_WMM youn_WMM fraction treiber_WMM |
| GCK | PARK7 | 0.031 | 0.238 | fraction |
| HSD17B14 | GCK | 0.018 | 0.177 | fraction |
| PUDP | GCK | 0.015 | 0.143 | fraction |
| NIT1 | NEDD8 | 0.011 | 0.148 | fraction treiber_WMM |
| PUDP | ACY1 | 0.006 | 0.008 | fraction |
| PUDP | NEDD8 | 0.005 | 0.01 | bioplex (PUDP) fraction |
| NEDD8 | GLUL | 0.004 | 0.015 | bioplex_WMM fraction |
| NIT1 | GLUL | 0.0 | 0.012 | bioplex_WMM fraction |
| ITPA | PUDP | 0.0 | 0.006 | fraction |
| HSD17B14 | NEDD8 | 0.0 | 0.006 | fraction |
| NIT1 | PUDP | 0.0 | 0.0 | fraction |
| ITPA | GLUL | 0.0 | 0.001 | bioplex_WMM fraction |
| GLUL | PARK7 | 0.0 | 0.0 | bioplex (GLUL) bioplex_WMM youn_WMM fraction |
| NIT1 | GCK | 0.0 | 0.001 | fraction |
Images
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Complex HuMAP2_00664 has an average edge precision of 0.272 which is ranked 4996 out of all 6965 complexes.
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