hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00665
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP6R3 | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | UniProt NCBI |
| PPP6C | Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] | UniProt NCBI |
| ANKRD28 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204005 | 1.61809928271e-05 | 1.0 | PPP6C PPP6R3 ANKRD28 | COPII-mediated vesicle transport |
| REAC:R-HSA-199977 | 0.000219108356997 | 1.0 | PPP6C PPP6R3 ANKRD28 | ER to Golgi Anterograde Transport |
| CORUM:5196 | 0.00022139720913 | 0.666666666667 | PPP6C ANKRD28 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
| REAC:R-HSA-948021 | 0.000355291261341 | 1.0 | PPP6C PPP6R3 ANKRD28 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-446203 | 0.00171641263924 | 1.0 | PPP6C PPP6R3 ANKRD28 | Asparagine N-linked glycosylation |
| GO:0048207 | 0.00310781167151 | 1.0 | PPP6C PPP6R3 ANKRD28 | vesicle targeting, rough ER to cis-Golgi |
| GO:0048208 | 0.00310781167151 | 1.0 | PPP6C PPP6R3 ANKRD28 | COPII vesicle coating |
| GO:0006901 | 0.00378386515143 | 1.0 | PPP6C PPP6R3 ANKRD28 | vesicle coating |
| GO:0090114 | 0.00415585803882 | 1.0 | PPP6C PPP6R3 ANKRD28 | COPII-coated vesicle budding |
| GO:0048199 | 0.00455146375597 | 1.0 | PPP6C PPP6R3 ANKRD28 | vesicle targeting, to, from or within Golgi |
| GO:0048194 | 0.00564855215433 | 1.0 | PPP6C PPP6R3 ANKRD28 | Golgi vesicle budding |
| GO:0006903 | 0.00865355719779 | 1.0 | PPP6C PPP6R3 ANKRD28 | vesicle targeting |
| GO:0006900 | 0.011404996777 | 1.0 | PPP6C PPP6R3 ANKRD28 | vesicle budding from membrane |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | PPP6C PPP6R3 ANKRD28 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | PPP6C PPP6R3 ANKRD28 | Vesicle-mediated transport |
| MIRNA:hsa-miR-4519 | 0.0302063424264 | 0.666666666667 | PPP6C PPP6R3 | hsa-miR-4519 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP6C | ANKRD28 | 0.897 | 0.822 | hein_WMM bioplex_WMM boldt youn_WMM hein (ANKRD28,PPP6C) gupta_WMM boldt_WMM |
| PPP6R3 | PPP6C | 0.772 | 0.751 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (PPP6C) gupta_WMM fraction boldt_WMM |
| PPP6R3 | ANKRD28 | 0.686 | 0.712 | hein_WMM bioplex_WMM boldt youn_WMM hein (ANKRD28) gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_00665 has an average edge precision of 0.762 which is ranked 1087 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPP6R3 | HuMAP2_00665 HuMAP2_02481 HuMAP2_05435 HuMAP2_06268 |
| PPP6C | HuMAP2_00665 HuMAP2_02481 HuMAP2_05435 HuMAP2_06268 |
| ANKRD28 | HuMAP2_00665 HuMAP2_02481 HuMAP2_05435 HuMAP2_06268 |