hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00674
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KLHL40 | Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin) | UniProt NCBI |
| KLHL41 | Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) | UniProt NCBI |
| DUSP11 | RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1) | UniProt NCBI |
| CEP85L | Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15) | UniProt NCBI |
| ZNF81 | Zinc finger protein 81 (HFZ20) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0007514 | 0.00167158658755 | 0.4 | KLHL41 KLHL40 | Edema of the dorsum of hands |
| HP:0005855 | 0.00422256197273 | 0.4 | KLHL41 KLHL40 | Multiple prenatal fractures |
| HP:0003798 | 0.00422256197273 | 0.4 | KLHL41 KLHL40 | Nemaline bodies |
| HP:0001623 | 0.00709565752293 | 0.4 | KLHL41 KLHL40 | Breech presentation |
| HP:0010827 | 0.00780468270807 | 0.6 | KLHL41 ZNF81 KLHL40 | Abnormality of the seventh cranial nerve |
| HP:0010628 | 0.00780468270807 | 0.6 | KLHL41 ZNF81 KLHL40 | Facial palsy |
| HP:0030319 | 0.0089379069678 | 0.6 | KLHL41 ZNF81 KLHL40 | Weakness of facial musculature |
| HP:0001989 | 0.0107072942689 | 0.4 | KLHL41 KLHL40 | Fetal akinesia sequence |
| HP:0100303 | 0.011725460578 | 0.4 | KLHL41 KLHL40 | Muscle fiber cytoplasmatic inclusion bodies |
| HP:0003327 | 0.011725460578 | 0.4 | KLHL41 KLHL40 | Axial muscle weakness |
| HP:0009025 | 0.0127896924378 | 0.4 | KLHL41 KLHL40 | Increased connective tissue |
| HP:0001291 | 0.0141499625944 | 0.6 | KLHL41 ZNF81 KLHL40 | Abnormal cranial nerve morphology |
| HP:0100299 | 0.0162585949147 | 0.4 | KLHL41 KLHL40 | Muscle fiber inclusion bodies |
| HP:0000301 | 0.0195292681717 | 0.6 | KLHL41 ZNF81 KLHL40 | Abnormality of facial musculature |
| HP:0006824 | 0.0205396289494 | 0.6 | KLHL41 ZNF81 KLHL40 | Cranial nerve paralysis |
| HP:0031910 | 0.0205396289494 | 0.6 | KLHL41 ZNF81 KLHL40 | Abnormal cranial nerve physiology |
| HP:0002375 | 0.0229596708254 | 0.4 | KLHL41 KLHL40 | Hypokinesia |
| HP:0000883 | 0.0229596708254 | 0.4 | KLHL41 KLHL40 | Thin ribs |
| HP:0001349 | 0.0275312401623 | 0.4 | KLHL41 KLHL40 | Facial diplegia |
| HP:0003803 | 0.0342683684383 | 0.4 | KLHL41 KLHL40 | Type 1 muscle fiber predominance |
| HP:0011799 | 0.0485960101036 | 0.6 | KLHL41 ZNF81 KLHL40 | Abnormality of facial soft tissue |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KLHL40 | CEP85L | 0.639 | 0.686 | bioplex (KLHL40) bioplex_WMM |
| ZNF81 | KLHL40 | 0.594 | 0.666 | bioplex (KLHL40) bioplex_WMM |
| KLHL41 | KLHL40 | 0.16 | 0.417 | bioplex (KLHL40) bioplex_WMM |
| DUSP11 | KLHL40 | 0.151 | 0.411 | bioplex (KLHL40) bioplex_WMM |
| KLHL41 | ZNF81 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ZNF81 | CEP85L | 0.008 | 0.087 | bioplex_WMM WMM_only |
| KLHL41 | CEP85L | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ZNF81 | DUSP11 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| KLHL41 | DUSP11 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| DUSP11 | CEP85L | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00674 has an average edge precision of 0.245 which is ranked 5448 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KLHL40 | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 |
| KLHL41 | HuMAP2_00258 HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 |
| DUSP11 | HuMAP2_00674 HuMAP2_01087 HuMAP2_02342 HuMAP2_02606 HuMAP2_03219 HuMAP2_07016 |
| CEP85L | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 HuMAP2_06680 |
| ZNF81 | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 |