hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00675
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HEXB | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | UniProt NCBI |
| GCAT | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase) | UniProt NCBI |
| PPIA | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | UniProt NCBI |
| PGM2L1 | Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1) | UniProt NCBI |
| HEXA | Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6274 | 6.70868171695e-06 | 0.4 | HEXB HEXA | HEXA-HEXB complex |
| WP:WP4153 | 0.00015011307213 | 0.4 | HEXB HEXA | Degradation pathway of sphingolipids, including diseases |
| KEGG:00603 | 0.000334402895448 | 0.4 | HEXB HEXA | Glycosphingolipid biosynthesis - globo and isoglobo series |
| KEGG:00604 | 0.000390084296529 | 0.4 | HEXB HEXA | Glycosphingolipid biosynthesis - ganglio series |
| KEGG:00531 | 0.000582748169105 | 0.4 | HEXB HEXA | Glycosaminoglycan degradation |
| KEGG:00511 | 0.000655503599737 | 0.4 | HEXB HEXA | Other glycan degradation |
| HP:0010969 | 0.000696775152219 | 0.4 | HEXB HEXA | Abnormality of glycolipid metabolism |
| HP:0004343 | 0.000696775152219 | 0.4 | HEXB HEXA | Abnormality of glycosphingolipid metabolism |
| REAC:R-HSA-2160916 | 0.000741476933235 | 0.4 | HEXB HEXA | Hyaluronan uptake and degradation |
| REAC:R-HSA-2022857 | 0.000889652787086 | 0.4 | HEXB HEXA | Keratan sulfate degradation |
| REAC:R-HSA-2024101 | 0.00105126658749 | 0.4 | HEXB HEXA | CS/DS degradation |
| REAC:R-HSA-2142845 | 0.00122631290825 | 0.4 | HEXB HEXA | Hyaluronan metabolism |
| HP:0010729 | 0.00167158658755 | 0.4 | HEXB HEXA | Cherry red spot of the macula |
| KEGG:00513 | 0.00269260965903 | 0.4 | HEXB HEXA | Various types of N-glycan biosynthesis |
| KEGG:00520 | 0.00441762805526 | 0.4 | HEXB HEXA | Amino sugar and nucleotide sugar metabolism |
| REAC:R-HSA-1638074 | 0.00546022370076 | 0.4 | HEXB HEXA | Keratan sulfate/keratin metabolism |
| REAC:R-HSA-71387 | 0.00784859202005 | 0.6 | PGM2L1 HEXB HEXA | Metabolism of carbohydrates |
| REAC:R-HSA-3560782 | 0.00995219083388 | 0.4 | HEXB HEXA | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-1660662 | 0.0104745816743 | 0.4 | HEXB HEXA | Glycosphingolipid metabolism |
| KEGG:01100 | 0.0121945453342 | 0.8 | GCAT PGM2L1 HEXB HEXA | Metabolic pathways |
| REAC:R-HSA-1793185 | 0.0145030354259 | 0.4 | HEXB HEXA | Chondroitin sulfate/dermatan sulfate metabolism |
| HP:0032243 | 0.0150562782431 | 0.4 | HEXB HEXA | Abnormal tissue metabolite concentration |
| CORUM:6275 | 0.0249780992026 | 0.2 | HEXB | HEXB homodimer complex |
| KEGG:04142 | 0.0291793560441 | 0.4 | HEXB HEXA | Lysosome |
| REAC:R-HSA-428157 | 0.0361060371214 | 0.4 | HEXB HEXA | Sphingolipid metabolism |
| HP:0000630 | 0.0437194132729 | 0.4 | HEXB HEXA | Abnormal retinal artery morphology |
| CORUM:5843 | 0.0499494897235 | 0.2 | PPIA | AIF-CYPA-DNA complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPIA | PGM2L1 | 0.506 | 0.626 | fraction |
| HEXB | PPIA | 0.123 | 0.395 | bioplex_WMM fraction |
| HEXB | HEXA | 0.033 | 0.253 | hein_WMM bioplex (HEXA) bioplex_WMM |
| PPIA | GCAT | 0.029 | 0.23 | bioplex (GCAT) fraction treiber_WMM |
| HEXB | PGM2L1 | 0.012 | 0.149 | fraction |
| HEXA | GCAT | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PPIA | HEXA | 0.006 | 0.002 | bioplex (HEXA) bioplex_WMM |
| HEXB | GCAT | 0.006 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00675 has an average edge precision of 0.208 which is ranked 6048 out of all 6965 complexes.
Related Complexes