hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00680
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NR2F6 | Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2) | UniProt NCBI |
| PHKA2 | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | UniProt NCBI |
| MPPED1 | Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) | UniProt NCBI |
| NR2F2 | COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2) | UniProt NCBI |
| MPPED2 | Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2) | UniProt NCBI |
| PHKA1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | UniProt NCBI |
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26) | UniProt NCBI |
| PHKB | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | UniProt NCBI |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-70221 | 8.21621277453e-12 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-8982491 | 2.69236368403e-10 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Glycogen metabolism |
| WP:WP500 | 6.1590278799e-10 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Glycogen Synthesis and Degradation |
| GO:0004689 | 3.07384073035e-09 | 0.444444444444 | PHKG2 PHKA2 PHKA1 PHKB | phosphorylase kinase activity |
| GO:0005964 | 3.07384073035e-09 | 0.444444444444 | PHKG2 PHKA2 PHKA1 PHKB | phosphorylase kinase complex |
| GO:0005980 | 4.49748144761e-09 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | glycogen catabolic process |
| CORUM:6640 | 6.30476064954e-09 | 0.333333333333 | PHKA1 PHKB PHKG1 | Phosphorylase kinase complex |
| GO:0000272 | 6.37000481812e-09 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | polysaccharide catabolic process |
| GO:0044247 | 6.37000481812e-09 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | cellular polysaccharide catabolic process |
| GO:0009251 | 6.37000481812e-09 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | glucan catabolic process |
| KEGG:04922 | 6.32710480599e-08 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Glucagon signaling pathway |
| GO:0044275 | 1.74360577179e-07 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | cellular carbohydrate catabolic process |
| KEGG:04910 | 2.41189489964e-07 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Insulin signaling pathway |
| KEGG:04020 | 8.11067731154e-07 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Calcium signaling pathway |
| GO:0005977 | 1.75045805272e-06 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | glycogen metabolic process |
| GO:0044042 | 1.94893635472e-06 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | glucan metabolic process |
| GO:0006073 | 1.94893635472e-06 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | cellular glucan metabolic process |
| GO:0006112 | 3.22862749801e-06 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | energy reserve metabolic process |
| GO:0044264 | 7.76645830023e-06 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | cellular polysaccharide metabolic process |
| GO:0005976 | 1.23117337567e-05 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | polysaccharide metabolic process |
| REAC:R-HSA-71387 | 3.84220572674e-05 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | Metabolism of carbohydrates |
| GO:0004683 | 3.8665216288e-05 | 0.444444444444 | PHKG2 PHKA2 PHKA1 PHKB | calmodulin-dependent protein kinase activity |
| GO:0016052 | 0.000674769519173 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | carbohydrate catabolic process |
| GO:0044262 | 0.00092585663312 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | cellular carbohydrate metabolic process |
| GO:0015980 | 0.00250489460284 | 0.555555555556 | PHKG2 PHKG1 PHKA2 PHKA1 PHKB | energy derivation by oxidation of organic compounds |
| GO:1902554 | 0.00347084399483 | 0.444444444444 | PHKG2 PHKA2 PHKA1 PHKB | serine/threonine protein kinase complex |
| GO:1902911 | 0.00700760799459 | 0.444444444444 | PHKG2 PHKA2 PHKA1 PHKB | protein kinase complex |
| WP:WP170 | 0.0128035909147 | 0.222222222222 | NR2F2 NR2F6 | Nuclear Receptors |
| CORUM:6097 | 0.0499262710315 | 0.111111111111 | NR2F2 | MEF2-NR2F2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHKA2 | PHKG2 | 1.0 | 0.949 | hein_WMM bioplex (PHKG2) bioplex_WMM hein (PHKG2) |
| PHKG2 | PHKA1 | 1.0 | 0.949 | hein_WMM bioplex (PHKG2) bioplex_WMM hein (PHKG2) boldt_WMM |
| PHKB | PHKG2 | 1.0 | 0.949 | hein_WMM bioplex (PHKG2) bioplex_WMM hein (PHKG2) boldt_WMM |
| PHKG2 | PHKG1 | 0.991 | 0.909 | bioplex (PHKG2) |
| PHKA2 | MPPED1 | 0.986 | 0.901 | bioplex (MPPED1) bioplex_WMM |
| MPPED1 | MPPED2 | 0.968 | 0.88 | bioplex (MPPED1) bioplex_WMM |
| PHKB | MPPED1 | 0.895 | 0.821 | bioplex (MPPED1) bioplex_WMM |
| NR2F6 | MPPED2 | 0.585 | 0.663 | bioplex (MPPED2) bioplex_WMM |
| PHKA1 | MPPED1 | 0.395 | 0.555 | bioplex (MPPED1) bioplex_WMM |
| PHKG2 | MPPED1 | 0.317 | 0.509 | bioplex (MPPED1) bioplex_WMM |
| NR2F6 | MPPED1 | 0.224 | 0.465 | bioplex (MPPED1) bioplex_WMM |
| NR2F6 | NR2F2 | 0.054 | 0.298 | bioplex (NR2F2) bioplex_WMM |
| PHKA2 | PHKB | 0.017 | 0.174 | hein_WMM bioplex_WMM WMM_only |
| MPPED1 | NR2F2 | 0.013 | 0.147 | bioplex (MPPED1) bioplex_WMM |
| PHKB | PHKA1 | 0.011 | 0.143 | hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM |
| PHKA2 | PHKA1 | 0.01 | 0.131 | hein_WMM bioplex_WMM WMM_only |
| PHKA2 | MPPED2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| PHKB | MPPED2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PHKA1 | MPPED2 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| PHKA2 | PHKG1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| PHKG2 | MPPED2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PHKB | PHKG1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| PHKA1 | PHKG1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| NR2F6 | PHKA2 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| NR2F6 | PHKB | 0.008 | 0.066 | bioplex_WMM WMM_only |
| NR2F6 | PHKA1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| NR2F6 | PHKG2 | 0.008 | 0.042 | bioplex_WMM WMM_only |
| NR2F2 | MPPED2 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| PHKA2 | NR2F2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| PHKB | NR2F2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PHKA1 | NR2F2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PHKG2 | NR2F2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00680 has an average edge precision of 0.323 which is ranked 4303 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NR2F6 | HuMAP2_00680 HuMAP2_01326 |
| PHKA2 | HuMAP2_00680 HuMAP2_05857 HuMAP2_06680 |
| MPPED1 | HuMAP2_00680 HuMAP2_06680 |
| NR2F2 | HuMAP2_00680 |
| MPPED2 | HuMAP2_00680 HuMAP2_01326 |
| PHKA1 | HuMAP2_00680 HuMAP2_05335 HuMAP2_06680 |
| PHKG1 | HuMAP2_00680 HuMAP2_05335 HuMAP2_06680 |
| PHKB | HuMAP2_00680 HuMAP2_06680 |
| PHKG2 | HuMAP2_00680 HuMAP2_05335 HuMAP2_06680 |