hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00689
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSPB8 | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22) | UniProt NCBI |
| HSPA1B | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) | UniProt NCBI |
| METTL21A | Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A) | UniProt NCBI |
| RPTOR | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | UniProt NCBI |
| CASP3 | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | UniProt NCBI |
| BAG3 | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | UniProt NCBI |
| HSPB6 | Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) | UniProt NCBI |
| CPZ | Carboxypeptidase Z (CPZ) (EC 3.4.17.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371556 | 1.20493481886e-05 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | Cellular response to heat stress |
| REAC:R-HSA-3371571 | 3.17792583502e-05 | 0.375 | HSPB8 RPTOR HSPA1B | HSF1-dependent transactivation |
| CORUM:6052 | 7.00904180673e-05 | 0.25 | HSPB8 BAG3 | BAG3-HSC70-HSPB8-CHIP complex |
| GO:1900034 | 0.00215722302686 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | regulation of cellular response to heat |
| REAC:R-HSA-2262752 | 0.0062507009655 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | Cellular responses to stress |
| GO:0034605 | 0.00739084325394 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | cellular response to heat |
| GO:0009408 | 0.0123557309189 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | response to heat |
| KEGG:05134 | 0.0124147017773 | 0.25 | CASP3 HSPA1B | Legionellosis |
| REAC:R-HSA-8953897 | 0.0127226554392 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | Cellular responses to external stimuli |
| KEGG:04213 | 0.0184225203577 | 0.25 | HSPA1B RPTOR | Longevity regulating pathway - multiple species |
| GO:0009266 | 0.025421718431 | 0.5 | HSPB8 HSPA1B RPTOR BAG3 | response to temperature stimulus |
| GO:0016241 | 0.0284637816739 | 0.5 | CASP3 HSPB8 RPTOR BAG3 | regulation of macroautophagy |
| GO:1905335 | 0.0378589948753 | 0.25 | HSPB8 BAG3 | regulation of aggrephagy |
| GO:1905337 | 0.0378589948753 | 0.25 | HSPB8 BAG3 | positive regulation of aggrephagy |
| WP:WP1772 | 0.0405256363219 | 0.25 | CASP3 BAG3 | Apoptosis Modulation and Signaling |
| CORUM:2985 | 0.0497224828424 | 0.125 | RPTOR | mTOR complex (MTOR, RAPTOR) |
| CORUM:2991 | 0.0497224828424 | 0.125 | RPTOR | mTOR complex (MTOR, RAPTOR) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAG3 | HSPB8 | 0.349 | 0.536 | hein_WMM bioplex (HSPB8) bioplex_WMM hein (BAG3) gupta_WMM |
| METTL21A | BAG3 | 0.079 | 0.35 | bioplex (METTL21A) bioplex_WMM |
| RPTOR | BAG3 | 0.057 | 0.321 | bioplex (RPTOR) bioplex_WMM youn_WMM |
| CASP3 | BAG3 | 0.053 | 0.301 | fraction |
| HSPB6 | BAG3 | 0.053 | 0.301 | bioplex (HSPB6) bioplex_WMM gupta_WMM |
| METTL21A | HSPA1B | 0.046 | 0.292 | bioplex (METTL21A) bioplex_WMM boldt |
| BAG3 | HSPA1B | 0.03 | 0.236 | hein_WMM bioplex_WMM boldt hein (BAG3) |
| HSPA1B | CPZ | 0.021 | 0.195 | bioplex (CPZ) bioplex_WMM |
| CASP3 | HSPA1B | 0.008 | 0.015 | bioplex (CASP3) |
| HSPB8 | HSPA1B | 0.007 | 0.004 | hein_WMM bioplex (HSPB8) bioplex_WMM |
| HSPB6 | HSPA1B | 0.007 | 0.004 | bioplex (HSPB6) |
| RPTOR | HSPA1B | 0.004 | 0.008 | bioplex (RPTOR) bioplex_WMM boldt |
| BAG3 | CPZ | 0.004 | 0.015 | bioplex (CPZ) bioplex_WMM |
Images
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Complex HuMAP2_00689 has an average edge precision of 0.198 which is ranked 6200 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSPB8 | HuMAP2_00689 HuMAP2_03772 HuMAP2_06990 |
| HSPA1B | HuMAP2_00689 HuMAP2_01327 HuMAP2_01418 HuMAP2_04281 |
| METTL21A | HuMAP2_00689 HuMAP2_01418 HuMAP2_04281 HuMAP2_05624 |
| RPTOR | HuMAP2_00689 HuMAP2_06990 |
| CASP3 | HuMAP2_00689 HuMAP2_06203 HuMAP2_06990 |
| BAG3 | HuMAP2_00689 HuMAP2_06990 |
| HSPB6 | HuMAP2_00689 HuMAP2_02613 HuMAP2_05639 HuMAP2_06990 |
| CPZ | HuMAP2_00689 HuMAP2_01327 |