hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00694

Confidence: Medium

Genename	Protein Name	Links
SPOCK1	Testican-1 (Protein SPOCK)	UniProt NCBI
SUPT4H1	Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)	UniProt NCBI
CFDP1	Craniofacial development protein 1 (Bucentaur)	UniProt NCBI
GTF2E2	Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2)	UniProt NCBI
GTF2E1	General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)	UniProt NCBI
GTF2F2	General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP-dependent helicase GTF2F2) (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)	UniProt NCBI
GTF2F1	General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)	UniProt NCBI
SMAP	Small acidic protein	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:103	1.67296632195e-08	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II holoenzyme complex
REAC:R-HSA-167172	2.09464996215e-08	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	Transcription of the HIV genome
CORUM:2825	2.35272794789e-08	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	BRCA1-RNA polymerase II complex
REAC:R-HSA-6807505	2.59027675215e-08	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II transcribes snRNA genes
REAC:R-HSA-674695	4.38154815861e-08	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Pre-transcription Events
KEGG:03022	1.82293784683e-07	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	Basal transcription factors
REAC:R-HSA-162599	5.11690681576e-07	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	8.19465161541e-07	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	HIV Life Cycle
REAC:R-HSA-75953	1.07016718079e-06	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription Initiation
REAC:R-HSA-167161	1.07016718079e-06	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	HIV Transcription Initiation
REAC:R-HSA-73779	1.07016718079e-06	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-76042	1.07016718079e-06	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-73776	1.07016718079e-06	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Promoter Escape
REAC:R-HSA-167162	1.07016718079e-06	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-162906	6.88764380494e-06	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	HIV Infection
CORUM:153	1.16880143691e-05	0.25	GTF2F2 GTF2F1	TFIIF complex (transcription factor IIF)
CORUM:152	1.16880143691e-05	0.25	GTF2E1 GTF2E2	TFIIE complex
REAC:R-HSA-167242	3.17792583502e-05	0.375	GTF2F2 GTF2F1 SUPT4H1	Abortive elongation of HIV-1 transcript in the absence of Tat
WP:WP405	5.43505087196e-05	0.375	GTF2E1 GTF2E2 GTF2F2	Eukaryotic Transcription Initiation
REAC:R-HSA-5663205	7.30114744836e-05	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	Infectious disease
REAC:R-HSA-167243	8.88017574576e-05	0.375	GTF2F2 GTF2F1 SUPT4H1	Tat-mediated HIV elongation arrest and recovery
REAC:R-HSA-167238	8.88017574576e-05	0.375	GTF2F2 GTF2F1 SUPT4H1	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-113418	9.76573076151e-05	0.375	GTF2F2 GTF2F1 SUPT4H1	Formation of the Early Elongation Complex
REAC:R-HSA-167158	9.76573076151e-05	0.375	GTF2F2 GTF2F1 SUPT4H1	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-167290	0.000107081011906	0.375	GTF2F2 GTF2F1 SUPT4H1	Pausing and recovery of HIV elongation
REAC:R-HSA-167287	0.000107081011906	0.375	GTF2F2 GTF2F1 SUPT4H1	HIV elongation arrest and recovery
REAC:R-HSA-167200	0.000236398544274	0.375	GTF2F2 GTF2F1 SUPT4H1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167246	0.000236398544274	0.375	GTF2F2 GTF2F1 SUPT4H1	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167169	0.000236398544274	0.375	GTF2F2 GTF2F1 SUPT4H1	HIV Transcription Elongation
REAC:R-HSA-167152	0.000270818480882	0.375	GTF2F2 GTF2F1 SUPT4H1	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-75955	0.000578076872206	0.375	GTF2F2 GTF2F1 SUPT4H1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	0.000578076872206	0.375	GTF2F2 GTF2F1 SUPT4H1	Formation of RNA Pol II elongation complex
REAC:R-HSA-6796648	0.000672008352303	0.375	GTF2F2 GTF2F1 SUPT4H1	TP53 Regulates Transcription of DNA Repair Genes
CORUM:3064	0.00122296268731	0.25	GTF2E1 GTF2F1	RNA polymerase II complex, chromatin structure modifying
GO:0016251	0.00145089086092	0.375	GTF2E1 GTF2E2 GTF2F1	RNA polymerase II general transcription initiation factor activity
GO:0042795	0.0015436837415	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	snRNA transcription by RNA polymerase II
CORUM:2685	0.00158317684197	0.25	GTF2F2 GTF2F1	RNA polymerase II (RNAPII)
GO:0009301	0.00163549131335	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	snRNA transcription
GO:0016591	0.00173132335192	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II, holoenzyme
GO:0140223	0.00413439262839	0.375	GTF2E1 GTF2E2 GTF2F1	general transcription initiation factor activity
GO:0055029	0.00556156731761	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	nuclear DNA-directed RNA polymerase complex
GO:0000428	0.00579952246378	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	DNA-directed RNA polymerase complex
GO:0030880	0.00655917985544	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase complex
GO:0098781	0.00682818709384	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	ncRNA transcription
REAC:R-HSA-8851708	0.00761952471968	0.25	GTF2F2 GTF2F1	Signaling by FGFR2 IIIa TM
REAC:R-HSA-1643685	0.00877565882558	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	Disease
GO:0005674	0.0126230555186	0.25	GTF2F2 GTF2F1	transcription factor TFIIF complex
GO:0005673	0.0126230555186	0.25	GTF2E1 GTF2E2	transcription factor TFIIE complex
REAC:R-HSA-1839126	0.0133460514177	0.25	GTF2F2 GTF2F1	FGFR2 mutant receptor activation
REAC:R-HSA-6803529	0.0144543373882	0.25	GTF2F2 GTF2F1	FGFR2 alternative splicing
REAC:R-HSA-77075	0.0156064896573	0.25	GTF2F2 GTF2F1	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-167160	0.0156064896573	0.25	GTF2F2 GTF2F1	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-72086	0.0180422506392	0.25	GTF2F2 GTF2F1	mRNA Capping
REAC:R-HSA-73857	0.0224473446481	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA Polymerase II Transcription
REAC:R-HSA-5655253	0.0248968222949	0.25	GTF2F2 GTF2F1	Signaling by FGFR2 in disease
GO:0090575	0.0300827873038	0.5	GTF2E1 GTF2F1 GTF2E2 GTF2F2	RNA polymerase II transcription factor complex
GO:0005669	0.0301968453576	0.375	GTF2E1 GTF2E2 GTF2F1	transcription factor TFIID complex
REAC:R-HSA-168325	0.0345601208955	0.25	GTF2F2 GTF2F1	Viral Messenger RNA Synthesis
REAC:R-HSA-74160	0.037866398773	0.625	SUPT4H1 GTF2E1 GTF2F1 GTF2E2 GTF2F2	Gene expression (Transcription)
CORUM:2860	0.0497224828424	0.125	SUPT4H1	DSIF complex (DRB sensitivity-inducing factor complex)
CORUM:2861	0.0497224828424	0.125	SUPT4H1	DSIF complex (DRB sensitivity-inducing factor complex)
GO:0050434	0.0497817121827	0.375	GTF2F2 GTF2F1 SUPT4H1	positive regulation of viral transcription

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GTF2E2	GTF2E1	1.0	0.949	hein_WMM bioplex (GTF2E2) bioplex_WMM Guru youn_WMM hein (GTF2E2) gupta_WMM fraction
GTF2F2	GTF2F1	1.0	0.949	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM
GTF2E2	GTF2F1	0.988	0.901	youn_WMM gupta_WMM fraction
GTF2E1	GTF2F1	0.987	0.902	youn_WMM gupta_WMM fraction
GTF2E1	GTF2F2	0.909	0.832	youn_WMM gupta_WMM fraction
GTF2E2	GTF2F2	0.718	0.73	youn_WMM gupta_WMM fraction
GTF2F2	CFDP1	0.553	0.645	youn_WMM gupta_WMM fraction
GTF2F2	SUPT4H1	0.246	0.469	youn_WMM fraction
GTF2F1	SUPT4H1	0.229	0.468	bioplex_WMM youn_WMM fraction
GTF2E2	SPOCK1	0.165	0.42	hein_WMM hein (GTF2E2)
GTF2F1	CFDP1	0.125	0.398	youn_WMM gupta_WMM fraction
GTF2F1	SMAP	0.031	0.24	bioplex_WMM gupta_WMM fraction
GTF2E1	SPOCK1	0.008	0.083	hein_WMM WMM_only
GTF2E1	CFDP1	0.007	0.009	youn_WMM gupta_WMM WMM_only
GTF2F2	SMAP	0.007	0.002	bioplex_WMM gupta_WMM WMM_only
GTF2E2	CFDP1	0.007	0.004	youn_WMM gupta_WMM WMM_only
GTF2E1	SMAP	0.007	0.007	bioplex_WMM gupta_WMM WMM_only
GTF2E2	SMAP	0.005	0.014	bioplex (GTF2E2) gupta_WMM
SUPT4H1	CFDP1	0.003	0.012	youn_WMM fraction
GTF2E1	SUPT4H1	0.003	0.011	youn_WMM fraction
GTF2E2	SUPT4H1	0.0	0.014	youn_WMM fraction
SUPT4H1	SMAP	0.0	0.004	bioplex_WMM fraction
CFDP1	SMAP	0.0	0.009	bioplex_WMM gupta_WMM fraction

Images

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Complex HuMAP2_00694 has an average edge precision of 0.351 which is ranked 3942 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SPOCK1	HuMAP2_00694 HuMAP2_04413 HuMAP2_04857 HuMAP2_05709
SUPT4H1	HuMAP2_00694 HuMAP2_04857 HuMAP2_05384 HuMAP2_05667 HuMAP2_06690
CFDP1	HuMAP2_00694 HuMAP2_04857
GTF2E2	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04413 HuMAP2_04857 HuMAP2_05709 HuMAP2_06800
GTF2E1	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04413 HuMAP2_04857 HuMAP2_06800
GTF2F2	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04857
GTF2F1	HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04857
SMAP	HuMAP2_00694 HuMAP2_04857

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00694