hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00695
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BBS9 | Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) | UniProt NCBI |
| BBS1 | Bardet-Biedl syndrome 1 protein (BBS2-like protein 2) | UniProt NCBI |
| BBS7 | Bardet-Biedl syndrome 7 protein (BBS2-like protein 1) | UniProt NCBI |
| TTC8 | Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) | UniProt NCBI |
| BBS4 | Bardet-Biedl syndrome 4 protein | UniProt NCBI |
| BBS2 | Bardet-Biedl syndrome 2 protein | UniProt NCBI |
| BBS5 | Bardet-Biedl syndrome 5 protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6163 | 1.32097821718e-23 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | BBSome |
| GO:0034464 | 1.24171952415e-20 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | BBSome |
| REAC:R-HSA-5620922 | 6.03625193428e-19 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | BBSome-mediated cargo-targeting to cilium |
| HP:0010747 | 9.09900267162e-18 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Medial flaring of the eyebrow |
| REAC:R-HSA-5620920 | 3.26478270114e-16 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Cargo trafficking to the periciliary membrane |
| WP:WP4656 | 2.6904175308e-15 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Joubert Syndrome |
| HP:0008724 | 2.91772060897e-15 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hypoplasia of the ovary |
| HP:0010462 | 3.84114814213e-15 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Aplasia/Hypoplasia of the ovary |
| WP:WP4536 | 3.271650533e-14 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Genes related to primary cilium development (based on CRISPR) |
| HP:0001162 | 1.10606847231e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Postaxial hand polydactyly |
| HP:0000003 | 2.09163199837e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Multicystic kidney dysplasia |
| HP:0002230 | 2.81791428732e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Generalized hirsutism |
| HP:0001395 | 2.81791428732e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hepatic fibrosis |
| HP:0031065 | 2.81791428732e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal ovarian morphology |
| HP:0000100 | 5.27791713343e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Nephrotic syndrome |
| HP:0100259 | 8.82595979945e-13 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Postaxial polydactyly |
| CORUM:6165 | 9.08345369489e-13 | 0.571428571429 | BBS9 BBS7 BBS2 BBS1 | BBSome core complex |
| HP:0000510 | 3.57703684e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Rod-cone dystrophy |
| HP:0000580 | 3.57703684e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Pigmentary retinopathy |
| CORUM:6601 | 4.54099480282e-12 | 0.571428571429 | BBS4 BBS5 TTC8 BBS1 | BBS1-BBS4-BBS5-PKD1-TTC8 complex |
| HP:0000512 | 5.30730247942e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal electroretinogram |
| WP:WP4352 | 5.70505624788e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Ciliary landscape |
| HP:0001161 | 6.11954457578e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hand polydactyly |
| HP:0001007 | 8.06785175335e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hirsutism |
| REAC:R-HSA-5617833 | 8.54603562385e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Cilium Assembly |
| HP:0000426 | 9.22667350345e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Prominent nasal bridge |
| HP:0006101 | 9.64336198425e-12 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Finger syndactyly |
| GO:0001103 | 1.09624169491e-11 | 0.857142857143 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 | RNA polymerase II repressing transcription factor binding |
| HP:0009997 | 1.60492207418e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Duplication of phalanx of hand |
| HP:0009142 | 1.67179382727e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Duplication of bones involving the upper extremities |
| HP:0004275 | 1.67179382727e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Duplication of hand bones |
| HP:0000137 | 2.48316326054e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the ovary |
| HP:0030453 | 2.68061404494e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal visual electrophysiology |
| HP:0000368 | 3.61104404225e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Low-set, posteriorly rotated ears |
| HP:0010442 | 4.47909591621e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Polydactyly |
| HP:0000107 | 5.52019212328e-11 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Renal cyst |
| REAC:R-HSA-1852241 | 1.25636419806e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Organelle biogenesis and maintenance |
| HP:0000556 | 1.62412887454e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Retinal dystrophy |
| HP:0000470 | 2.10604740084e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Short neck |
| HP:0000822 | 2.29177462893e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hypertension |
| HP:0007703 | 3.82711105777e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of retinal pigmentation |
| HP:0003319 | 4.58113286853e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the cervical spine |
| HP:0032263 | 5.06661374911e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Increased blood pressure |
| HP:0000135 | 6.96132083532e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hypogonadism |
| HP:0001159 | 7.47586953161e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Syndactyly |
| HP:0000358 | 7.47586953161e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Posteriorly rotated ears |
| HP:0001513 | 9.21982434163e-10 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Obesity |
| HP:0004207 | 1.18151114131e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal 5th finger morphology |
| GO:0070491 | 1.27903958086e-09 | 0.857142857143 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 | repressing transcription factor binding |
| HP:0030972 | 1.63466812151e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal systemic blood pressure |
| HP:0004324 | 1.89257375721e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Increased body weight |
| HP:0008736 | 2.01334173938e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hypoplasia of penis |
| HP:0000494 | 2.27480911859e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Downslanted palpebral fissures |
| HP:0000534 | 4.7946781347e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal eyebrow morphology |
| HP:0000050 | 5.43747933159e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hypoplastic male external genitalia |
| HP:0003202 | 6.82864416117e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Skeletal muscle atrophy |
| HP:0003241 | 7.56717584391e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | External genital hypoplasia |
| HP:0000464 | 7.56717584391e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the neck |
| HP:0000008 | 9.25158852781e-09 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of female internal genitalia |
| HP:0000080 | 1.05449076718e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of reproductive system physiology |
| HP:0000812 | 1.53962087825e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal internal genitalia |
| HP:0011362 | 1.76535350561e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal hair quantity |
| HP:0010460 | 2.1727573501e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the female genitalia |
| HP:0200006 | 2.51087863031e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Slanting of the palpebral fissure |
| GO:0036064 | 3.09446048122e-08 | 0.857142857143 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 | ciliary basal body |
| HP:0005918 | 3.14561045199e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal finger phalanx morphology |
| HP:0012211 | 3.18947354594e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal renal physiology |
| HP:0030236 | 3.55965536512e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of muscle size |
| HP:0008373 | 3.80923763277e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Puberty and gonadal disorders |
| HP:0000036 | 3.91318875945e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the penis |
| HP:0000369 | 4.12840407572e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Low-set ears |
| HP:0000028 | 4.41162486409e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Cryptorchidism |
| HP:0000357 | 6.24677555887e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal location of ears |
| HP:0008050 | 6.48613426786e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the palpebral fissures |
| GO:0060271 | 9.90506464791e-08 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cilium assembly |
| GO:0044441 | 1.2049498564e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | ciliary part |
| GO:0044782 | 1.42782094838e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cilium organization |
| HP:0410042 | 1.76320248895e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal liver morphology |
| HP:0000479 | 2.30002878301e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal retinal morphology |
| HP:0000035 | 2.44791621342e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal testis morphology |
| HP:0000422 | 3.65857023341e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the nasal bridge |
| HP:0012210 | 3.76708032126e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal renal morphology |
| HP:0000639 | 5.25178730322e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Nystagmus |
| GO:0005929 | 5.31619461792e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cilium |
| HP:0012547 | 5.75849230206e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal involuntary eye movements |
| HP:0011277 | 6.02717713404e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the urinary system physiology |
| HP:0001392 | 7.53788338578e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the liver |
| HP:0000032 | 7.53788338578e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of male external genitalia |
| HP:0001167 | 9.28255180659e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of finger |
| HP:0010461 | 9.5231989703e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the male genitalia |
| HP:0000811 | 9.60459383329e-07 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal external genitalia |
| HP:0000356 | 1.01912382525e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the outer ear |
| GO:0120031 | 1.04749735336e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | plasma membrane bounded cell projection assembly |
| GO:0030031 | 1.20548211392e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cell projection assembly |
| HP:0001595 | 1.24418766677e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal hair morphology |
| HP:0002167 | 1.38297626804e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Neurological speech impairment |
| HP:0000492 | 1.52266158169e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal eyelid morphology |
| HP:0011025 | 1.85293722911e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal cardiovascular system physiology |
| HP:0001098 | 2.29400056592e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal fundus morphology |
| HP:0004329 | 2.34619148988e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal posterior eye segment morphology |
| HP:0002012 | 2.38154803193e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the abdominal organs |
| HP:0000077 | 2.52758043529e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the kidney |
| GO:0051904 | 2.60687308082e-06 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | pigment granule transport |
| GO:0032402 | 2.60687308082e-06 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | melanosome transport |
| HP:0011138 | 2.9693948457e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of skin adnexa morphology |
| HP:0010935 | 3.07855242026e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the upper urinary tract |
| HP:0000818 | 3.28371810656e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the endocrine system |
| HP:0004322 | 3.28371810656e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Short stature |
| GO:0032401 | 3.30150663924e-06 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | establishment of melanosome localization |
| GO:0051905 | 3.30150663924e-06 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | establishment of pigment granule localization |
| HP:0011297 | 3.70336756375e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal digit morphology |
| GO:0061629 | 3.74211430707e-06 | 0.857142857143 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 | RNA polymerase II-specific DNA-binding transcription factor binding |
| HP:0012243 | 4.11101750844e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal reproductive system morphology |
| HP:0030669 | 4.43387078019e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal ocular adnexa morphology |
| HP:0032039 | 4.94216098169e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the ocular adnexa |
| GO:0051875 | 5.09627015667e-06 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | pigment granule localization |
| GO:0032400 | 5.09627015667e-06 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | melanosome localization |
| HP:0000925 | 5.11090253856e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the vertebral column |
| HP:0001155 | 5.11090253856e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the hand |
| HP:0000002 | 5.2845585328e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of body height |
| HP:0000315 | 5.57292728015e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the orbital region |
| HP:0000365 | 6.27147624673e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hearing impairment |
| HP:0000364 | 6.86545780026e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Hearing abnormality |
| HP:0031704 | 6.86545780026e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal ear physiology |
| GO:0005815 | 8.130262579e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | microtubule organizing center |
| HP:0002817 | 9.05682107045e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the upper limb |
| HP:0000078 | 9.22587749555e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the genital system |
| HP:0040068 | 9.74937617558e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of limb bone |
| HP:0002813 | 9.74937617558e-06 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of limb bone morphology |
| HP:0000496 | 1.29931710758e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of eye movement |
| HP:0000366 | 1.3457166754e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the nose |
| HP:0004323 | 1.39352931181e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of body weight |
| GO:0140297 | 1.60497349693e-05 | 0.857142857143 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 | DNA-binding transcription factor binding |
| HP:0011844 | 1.63640673777e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal appendicular skeleton morphology |
| GO:0070925 | 1.94584784529e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | organelle assembly |
| HP:0001510 | 2.10270926593e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Growth delay |
| HP:0011805 | 2.38211342629e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal skeletal muscle morphology |
| CORUM:6166 | 3.02079974644e-05 | 0.285714285714 | BBS4 TTC8 | BBSome linker complex |
| HP:0000079 | 3.93921811913e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the urinary system |
| HP:0031703 | 4.66025311992e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal ear morphology |
| HP:0001249 | 4.66025311992e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Intellectual disability |
| GO:0120038 | 5.17136010679e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | plasma membrane bounded cell projection part |
| GO:0044463 | 5.17136010679e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cell projection part |
| HP:0040064 | 9.48001441422e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of limbs |
| HP:0000598 | 9.56401413994e-05 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the ear |
| GO:0033059 | 0.00010471199091 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | cellular pigmentation |
| HP:0012372 | 0.000169999607517 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal eye morphology |
| GO:0015630 | 0.000185300502203 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | microtubule cytoskeleton |
| HP:0012373 | 0.000199607679368 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal eye physiology |
| HP:0001574 | 0.000253237134134 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the integument |
| HP:0000119 | 0.000263111486607 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the genitourinary system |
| HP:0000546 | 0.000266971429668 | 0.571428571429 | TTC8 BBS4 BBS2 BBS1 | Retinal degeneration |
| HP:0001507 | 0.000271246841919 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Growth abnormality |
| HP:0001626 | 0.000293635621927 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the cardiovascular system |
| HP:0009121 | 0.000314068768055 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormal axial skeleton morphology |
| GO:0120036 | 0.000323372649013 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | plasma membrane bounded cell projection organization |
| GO:0030030 | 0.00034892458074 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cell projection organization |
| HP:0011446 | 0.000358614380642 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of higher mental function |
| GO:0043473 | 0.000385172296353 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | pigmentation |
| HP:0012759 | 0.000464150832236 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Neurodevelopmental abnormality |
| HP:0025031 | 0.000535373812148 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the digestive system |
| HP:0003011 | 0.000579282978702 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the musculature |
| HP:0000271 | 0.000601351086636 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the face |
| GO:0008134 | 0.000619191026608 | 0.857142857143 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 | transcription factor binding |
| GO:0120025 | 0.000809266549148 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | plasma membrane bounded cell projection |
| GO:0042995 | 0.000859920629778 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cell projection |
| HP:0000478 | 0.000873158287006 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the eye |
| HP:0011842 | 0.000930854263128 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of skeletal morphology |
| HP:0000007 | 0.000936799485409 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Autosomal recessive inheritance |
| GO:0044430 | 0.00101646279483 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cytoskeletal part |
| HP:0000924 | 0.00117729149668 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the skeletal system |
| HP:0000234 | 0.001199218279 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the head |
| HP:0000152 | 0.00125557272691 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of head or neck |
| CORUM:0000000 | 0.00178557880024 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | CORUM root |
| HP:0012638 | 0.0032513654002 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of nervous system physiology |
| GO:0045444 | 0.00449957152016 | 0.571428571429 | BBS9 BBS7 BBS2 BBS4 | fat cell differentiation |
| GO:0005856 | 0.00458974846823 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | cytoskeleton |
| HP:0000707 | 0.00515685892589 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Abnormality of the nervous system |
| GO:0045494 | 0.00822626332948 | 0.428571428571 | BBS4 BBS2 BBS1 | photoreceptor cell maintenance |
| GO:1905515 | 0.0142076090165 | 0.428571428571 | BBS4 TTC8 BBS1 | non-motile cilium assembly |
| HP:0000005 | 0.0193235311829 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Mode of inheritance |
| GO:0051650 | 0.0208141612097 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | establishment of vesicle localization |
| GO:0001947 | 0.0225450636661 | 0.428571428571 | BBS4 BBS7 BBS5 | heart looping |
| HP:0000662 | 0.0228812841091 | 0.428571428571 | BBS4 BBS2 TTC8 | Nyctalopia |
| GO:0007389 | 0.0247675148061 | 0.571428571429 | BBS4 BBS5 BBS7 TTC8 | pattern specification process |
| GO:0051648 | 0.0253749350715 | 0.571428571429 | BBS4 BBS5 BBS2 BBS7 | vesicle localization |
| GO:0005813 | 0.0257043347096 | 0.714285714286 | BBS1 BBS9 TTC8 BBS7 BBS4 | centrosome |
| GO:0061371 | 0.026626530587 | 0.428571428571 | BBS4 BBS7 BBS5 | determination of heart left/right asymmetry |
| GO:0038108 | 0.0283955176165 | 0.285714285714 | BBS4 BBS2 | negative regulation of appetite by leptin-mediated signaling pathway |
| GO:0050893 | 0.0283955176165 | 0.285714285714 | BBS4 TTC8 | sensory processing |
| GO:0003143 | 0.0311716432999 | 0.428571428571 | BBS4 BBS7 BBS5 | embryonic heart tube morphogenesis |
| HP:0000118 | 0.0317978942459 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | Phenotypic abnormality |
| HP:0000001 | 0.0321049061652 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | HP root |
| GO:0035050 | 0.0362050681854 | 0.428571428571 | BBS4 BBS7 BBS5 | embryonic heart tube development |
| GO:0061512 | 0.0389125948999 | 0.428571428571 | BBS1 BBS9 BBS4 | protein localization to cilium |
| HP:0100691 | 0.0394192275604 | 0.428571428571 | BBS1 BBS2 TTC8 | Abnormality of the curvature of the cornea |
| WP:000000 | 0.0394625231882 | 1.0 | BBS1 TTC8 BBS4 BBS7 BBS2 BBS5 BBS9 | WIKIPATHWAYS |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BBS1 | BBS5 | 0.997 | 0.93 | bioplex (BBS1,BBS5) bioplex_WMM boldt (BBS1,BBS5) boldt_WMM |
| BBS9 | BBS5 | 0.996 | 0.928 | bioplex (BBS5) bioplex_WMM boldt (BBS5,BBS9) boldt_WMM |
| BBS4 | BBS5 | 0.995 | 0.924 | bioplex (BBS5) bioplex_WMM boldt (BBS4,BBS5) boldt_WMM |
| BBS9 | BBS1 | 0.992 | 0.912 | bioplex (BBS1) bioplex_WMM boldt (BBS1,BBS9) boldt_WMM |
| TTC8 | BBS5 | 0.986 | 0.9 | bioplex (BBS5) bioplex_WMM boldt (BBS5,TTC8) boldt_WMM |
| BBS4 | BBS1 | 0.979 | 0.895 | bioplex (BBS1) bioplex_WMM boldt (BBS1,BBS4) boldt_WMM |
| BBS2 | BBS7 | 0.976 | 0.891 | bioplex (BBS7) bioplex_WMM boldt (BBS2,BBS7) boldt_WMM |
| BBS1 | TTC8 | 0.973 | 0.886 | bioplex (BBS1) bioplex_WMM boldt (BBS1,TTC8) boldt_WMM |
| BBS2 | BBS5 | 0.948 | 0.857 | bioplex (BBS5) bioplex_WMM boldt (BBS2,BBS5) boldt_WMM |
| BBS9 | BBS7 | 0.858 | 0.795 | bioplex (BBS7) bioplex_WMM boldt (BBS9) boldt_WMM |
| BBS7 | BBS5 | 0.823 | 0.774 | bioplex (BBS5,BBS7) bioplex_WMM boldt (BBS5) boldt_WMM |
| BBS1 | BBS2 | 0.699 | 0.721 | bioplex (BBS1) bioplex_WMM boldt (BBS1,BBS2) boldt_WMM |
| BBS1 | BBS7 | 0.444 | 0.587 | bioplex (BBS1,BBS7) bioplex_WMM boldt (BBS1) boldt_WMM |
| BBS4 | BBS7 | 0.324 | 0.513 | bioplex (BBS7) bioplex_WMM boldt (BBS4) boldt_WMM |
| BBS7 | TTC8 | 0.169 | 0.426 | bioplex (BBS7) bioplex_WMM boldt (TTC8) boldt_WMM |
| BBS9 | TTC8 | 0.146 | 0.409 | bioplex_WMM boldt (BBS9,TTC8) boldt_WMM |
| BBS9 | BBS2 | 0.112 | 0.381 | bioplex_WMM boldt (BBS2,BBS9) boldt_WMM |
| BBS4 | TTC8 | 0.088 | 0.353 | bioplex_WMM boldt (BBS4,TTC8) boldt_WMM |
| BBS9 | BBS4 | 0.039 | 0.265 | bioplex_WMM boldt (BBS4) boldt_WMM |
| BBS2 | TTC8 | 0.025 | 0.213 | bioplex_WMM boldt (TTC8) boldt_WMM |
| BBS4 | BBS2 | 0.021 | 0.187 | bioplex_WMM boldt (BBS4) boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_00695 has an average edge precision of 0.655 which is ranked 1627 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BBS9 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS1 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS7 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 HuMAP2_05079 |
| TTC8 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS4 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS2 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS5 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |