hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00704
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IER5 | Immediate early response gene 5 protein | UniProt NCBI |
| PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | UniProt NCBI |
| PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000159 | 8.80032001664e-05 | 1.0 | IER5 PPP2R2C PPP2R2B | protein phosphatase type 2A complex |
| WP:WP500 | 0.000673229988357 | 0.666666666667 | PPP2R2B PPP2R2C | Glycogen Synthesis and Degradation |
| GO:0008287 | 0.000829990966275 | 1.0 | IER5 PPP2R2C PPP2R2B | protein serine/threonine phosphatase complex |
| GO:1903293 | 0.000829990966275 | 1.0 | IER5 PPP2R2C PPP2R2B | phosphatase complex |
| KEGG:03015 | 0.0017077231529 | 0.666666666667 | PPP2R2B PPP2R2C | mRNA surveillance pathway |
| KEGG:05142 | 0.0017077231529 | 0.666666666667 | PPP2R2B PPP2R2C | Chagas disease (American trypanosomiasis) |
| KEGG:04071 | 0.00262334701465 | 0.666666666667 | PPP2R2B PPP2R2C | Sphingolipid signaling pathway |
| KEGG:04152 | 0.00277005173367 | 0.666666666667 | PPP2R2B PPP2R2C | AMPK signaling pathway |
| KEGG:04728 | 0.00323398213006 | 0.666666666667 | PPP2R2B PPP2R2C | Dopaminergic synapse |
| KEGG:04261 | 0.00367632825889 | 0.666666666667 | PPP2R2B PPP2R2C | Adrenergic signaling in cardiomyocytes |
| KEGG:05160 | 0.00408648948727 | 0.666666666667 | PPP2R2B PPP2R2C | Hepatitis C |
| WP:WP399 | 0.00444703604854 | 0.666666666667 | PPP2R2B PPP2R2C | Wnt Signaling Pathway and Pluripotency |
| KEGG:04390 | 0.00445520604942 | 0.666666666667 | PPP2R2B PPP2R2C | Hippo signaling pathway |
| KEGG:04530 | 0.00464549646756 | 0.666666666667 | PPP2R2B PPP2R2C | Tight junction |
| KEGG:04151 | 0.0198175756043 | 0.666666666667 | PPP2R2B PPP2R2C | PI3K-Akt signaling pathway |
| KEGG:05165 | 0.0214257750703 | 0.666666666667 | PPP2R2B PPP2R2C | Human papillomavirus infection |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | PPP2R2B PPP2R2C | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP4172 | 0.0388642175144 | 0.666666666667 | PPP2R2B PPP2R2C | PI3K-Akt Signaling Pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IER5 | PPP2R2C | 0.725 | 0.735 | bioplex (PPP2R2C) bioplex_WMM |
| PPP2R2B | PPP2R2C | 0.073 | 0.357 | bioplex (PPP2R2C) bioplex_WMM |
| IER5 | PPP2R2B | 0.009 | 0.104 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00704 has an average edge precision of 0.399 which is ranked 3343 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IER5 | HuMAP2_00115 HuMAP2_00202 HuMAP2_00704 HuMAP2_06073 |
| PPP2R2B | HuMAP2_00115 HuMAP2_00704 HuMAP2_06073 |
| PPP2R2C | HuMAP2_00115 HuMAP2_00202 HuMAP2_00704 HuMAP2_06073 |