hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00728
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | UniProt NCBI |
| CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | UniProt NCBI |
| DNAH14 | Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14) | UniProt NCBI |
| PUSL1 | tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 3.59524219422e-10 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | CaMK IV-mediated phosphorylation of CREB |
| GO:0005954 | 8.5384464732e-10 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | calcium- and calmodulin-dependent protein kinase complex |
| REAC:R-HSA-442982 | 8.7186390663e-09 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 1.10418282249e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 1.10418282249e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 1.38000589566e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Long-term potentiation |
| REAC:R-HSA-3371571 | 2.52095754391e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | HSF1-dependent transactivation |
| REAC:R-HSA-399719 | 4.25410234044e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Trafficking of AMPA receptors |
| REAC:R-HSA-442742 | 4.25410234044e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-399721 | 4.25410234044e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-9022692 | 6.75520268158e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Regulation of MECP2 expression and activity |
| REAC:R-HSA-5673000 | 6.75520268158e-08 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | RAF activation |
| WP:WP4008 | 1.11395735011e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | NO/cGMP/PKG mediated Neuroprotection |
| REAC:R-HSA-111997 | 1.16308570792e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | CaM pathway |
| REAC:R-HSA-111933 | 1.16308570792e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Calmodulin induced events |
| REAC:R-HSA-111996 | 1.48776903705e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Ca-dependent events |
| REAC:R-HSA-5576892 | 1.87601191777e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Phase 0 - rapid depolarisation |
| REAC:R-HSA-9609736 | 2.09638069879e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-1489509 | 2.33558991713e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | DAG and IP3 signaling |
| REAC:R-HSA-6802955 | 3.85165848913e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 3.85165848913e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-5578775 | 4.22674731879e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Ion homeostasis |
| KEGG:04971 | 4.62790542245e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Gastric acid secretion |
| KEGG:04720 | 4.94627169088e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Long-term potentiation |
| KEGG:05031 | 4.94627169088e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Amphetamine addiction |
| REAC:R-HSA-936837 | 5.05829239998e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Ion transport by P-type ATPases |
| WP:WP4341 | 5.35940799917e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| REAC:R-HSA-112043 | 7.08239116161e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | PLC beta mediated events |
| KEGG:05214 | 7.21394617076e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Glioma |
| REAC:R-HSA-112040 | 7.67135087323e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | G-protein mediated events |
| REAC:R-HSA-8986944 | 8.29624300828e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Transcriptional Regulation by MECP2 |
| KEGG:04911 | 9.10728516584e-07 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Insulin secretion |
| REAC:R-HSA-6802949 | 1.04009229777e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Signaling by RAS mutants |
| KEGG:04012 | 1.32857234855e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | ErbB signaling pathway |
| KEGG:04750 | 1.47067043937e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Inflammatory mediator regulation of TRP channels |
| KEGG:04912 | 1.47067043937e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | GnRH signaling pathway |
| REAC:R-HSA-6802952 | 1.68489749807e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Signaling by BRAF and RAF fusions |
| WP:WP673 | 1.81529925821e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | ErbB Signaling Pathway |
| KEGG:04925 | 2.05895087476e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Aldosterone synthesis and secretion |
| KEGG:04713 | 2.05895087476e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Circadian entrainment |
| KEGG:04916 | 2.15549375485e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Melanogenesis |
| KEGG:04922 | 2.92934047254e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Glucagon signaling pathway |
| KEGG:04725 | 2.92934047254e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cholinergic synapse |
| REAC:R-HSA-438064 | 3.07375784275e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Post NMDA receptor activation events |
| REAC:R-HSA-877300 | 3.43135578902e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Interferon gamma signaling |
| KEGG:04066 | 3.45553977964e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | HIF-1 signaling pathway |
| REAC:R-HSA-6802957 | 4.02500875924e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Oncogenic MAPK signaling |
| KEGG:04722 | 4.54258153483e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Neurotrophin signaling pathway |
| KEGG:04114 | 4.54258153483e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Oocyte meiosis |
| WP:WP428 | 4.6102370045e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Wnt Signaling |
| REAC:R-HSA-442755 | 5.4392781937e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-3371556 | 5.70696087866e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cellular response to heat stress |
| REAC:R-HSA-111885 | 5.98438062164e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Opioid Signalling |
| WP:WP536 | 7.3230510088e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Calcium Regulation in the Cardiac Cell |
| KEGG:04728 | 7.46106182314e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Dopaminergic synapse |
| KEGG:04740 | 8.23504176327e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Olfactory transduction |
| KEGG:04261 | 9.65640805164e-06 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Adrenergic signaling in cardiomyocytes |
| WP:WP289 | 1.04264299585e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Myometrial Relaxation and Contraction Pathways |
| GO:0004683 | 1.07646157797e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | calmodulin-dependent protein kinase activity |
| KEGG:04921 | 1.15953300137e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Oxytocin signaling pathway |
| KEGG:04934 | 1.38113838363e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cushing syndrome |
| REAC:R-HSA-5576891 | 1.56194883493e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cardiac conduction |
| KEGG:04310 | 1.63295382669e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Wnt signaling pathway |
| KEGG:05152 | 1.77099885498e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Tuberculosis |
| KEGG:04217 | 1.86774996349e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Necroptosis |
| KEGG:04020 | 2.23771835767e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Calcium signaling pathway |
| KEGG:04360 | 2.5961755562e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Axon guidance |
| KEGG:04024 | 2.9262549656e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | cAMP signaling pathway |
| KEGG:05205 | 4.37888853972e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Proteoglycans in cancer |
| REAC:R-HSA-983712 | 7.32162449256e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Ion channel transport |
| REAC:R-HSA-397014 | 9.7846880833e-05 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Muscle contraction |
| REAC:R-HSA-913531 | 0.000102486232537 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Interferon Signaling |
| REAC:R-HSA-112314 | 0.00010486652338 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-5673001 | 0.000158426073041 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.000175396215465 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.000221637163545 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | FLT3 Signaling |
| REAC:R-HSA-112315 | 0.000296731739946 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Transmission across Chemical Synapses |
| REAC:R-HSA-449836 | 0.000296731739946 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.000346508302524 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | MAPK family signaling cascades |
| REAC:R-HSA-418594 | 0.000517516161286 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 0.000533481886885 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Intracellular signaling by second messengers |
| REAC:R-HSA-442729 | 0.000664182971726 | 0.285714285714 | CAMK2G CAMK2B | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde |
| GO:0060333 | 0.000868835004821 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | interferon-gamma-mediated signaling pathway |
| GO:1900034 | 0.00108279884503 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | regulation of cellular response to heat |
| REAC:R-HSA-5663202 | 0.00142807956631 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Diseases of signal transduction |
| REAC:R-HSA-112316 | 0.00149643184588 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Neuronal System |
| KEGG:05200 | 0.00159650327269 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Pathways in cancer |
| GO:0005516 | 0.00162634417992 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | calmodulin binding |
| REAC:R-HSA-2262752 | 0.00301271618311 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cellular responses to stress |
| GO:0034605 | 0.00371517273942 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | cellular response to heat |
| GO:0071346 | 0.00401549948599 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | cellular response to interferon-gamma |
| GO:0030666 | 0.00540167841872 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | endocytic vesicle membrane |
| GO:0034341 | 0.00600405356651 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | response to interferon-gamma |
| REAC:R-HSA-8953897 | 0.00615930257424 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cellular responses to external stimuli |
| GO:0009408 | 0.00621557888043 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | response to heat |
| REAC:R-HSA-449147 | 0.00732463375585 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Signaling by Interleukins |
| REAC:R-HSA-388396 | 0.00903420497711 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | GPCR downstream signalling |
| GO:0051924 | 0.0107359250842 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | regulation of calcium ion transport |
| REAC:R-HSA-372790 | 0.0124590407181 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Signaling by GPCR |
| GO:0009266 | 0.0128043489742 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | response to temperature stimulus |
| REAC:R-HSA-382551 | 0.0140299310137 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Transport of small molecules |
| REAC:R-HSA-1280215 | 0.0238923711979 | 0.571428571429 | CAMK2A CAMK2G CAMK2D CAMK2B | Cytokine Signaling in Immune system |
| GO:0043502 | 0.0245293846287 | 0.428571428571 | CAMK2G CAMK2D CAMK2B | regulation of muscle adaptation |
| GO:0010663 | 0.0283955176165 | 0.285714285714 | CAMK2A CAMK2D | positive regulation of striated muscle cell apoptotic process |
| GO:0010666 | 0.0283955176165 | 0.285714285714 | CAMK2A CAMK2D | positive regulation of cardiac muscle cell apoptotic process |
| CORUM:5655 | 0.0499886427319 | 0.142857142857 | CAMK2A | Ternary complex (LRRC7, CAMK2a, ACTN4) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAMK2G | CAMK2D | 1.0 | 0.949 | bioplex (CAMK2D) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2D | CAMK2A | 0.996 | 0.928 | bioplex (CAMK2D) bioplex_WMM boldt (CAMK2A) boldt_WMM |
| CAMK2B | CAMK2D | 0.988 | 0.901 | bioplex (CAMK2D) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| UNG | CAMK2D | 0.269 | 0.483 | bioplex (CAMK2D) bioplex_WMM |
| CAMK2D | DNAH14 | 0.035 | 0.263 | bioplex (CAMK2D) bioplex_WMM youn_WMM |
| CAMK2D | PUSL1 | 0.024 | 0.213 | bioplex (CAMK2D) bioplex_WMM |
| CAMK2B | CAMK2A | 0.022 | 0.207 | bioplex_WMM boldt (CAMK2A) boldt_WMM |
| CAMK2G | CAMK2B | 0.01 | 0.14 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2G | CAMK2A | 0.009 | 0.098 | bioplex_WMM boldt (CAMK2A) boldt_WMM |
| DNAH14 | PUSL1 | 0.008 | 0.065 | bioplex_WMM WMM_only |
| UNG | CAMK2A | 0.008 | 0.066 | bioplex_WMM WMM_only |
| UNG | CAMK2B | 0.008 | 0.059 | bioplex_WMM WMM_only |
| UNG | DNAH14 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| UNG | PUSL1 | 0.008 | 0.032 | bioplex_WMM WMM_only |
| UNG | CAMK2G | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| CAMK2A | DNAH14 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| CAMK2A | PUSL1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CAMK2B | DNAH14 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CAMK2B | PUSL1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CAMK2G | DNAH14 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CAMK2G | PUSL1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00728 has an average edge precision of 0.214 which is ranked 5959 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UNG | HuMAP2_00728 HuMAP2_02007 HuMAP2_02476 HuMAP2_03797 |
| CAMK2G | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05617 |
| CAMK2B | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645 |
| CAMK2A | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645 |
| CAMK2D | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 |
| DNAH14 | HuMAP2_00728 HuMAP2_01838 HuMAP2_04053 |
| PUSL1 | HuMAP2_00728 HuMAP2_06390 HuMAP2_06562 |