hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00730
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | UniProt NCBI |
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | UniProt NCBI |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4582 | 5.16132609016e-18 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Cancer immunotherapy by CTLA4 blockade |
| REAC:R-HSA-8853659 | 1.3650479171e-17 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | RET signaling |
| KEGG:04930 | 6.23472188968e-17 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Type II diabetes mellitus |
| KEGG:04923 | 6.23472188968e-17 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Regulation of lipolysis in adipocytes |
| REAC:R-HSA-2219530 | 2.35571739768e-16 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Constitutive Signaling by Aberrant PI3K in Cancer |
| KEGG:04213 | 3.77327520401e-16 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-912526 | 9.5588108847e-16 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Interleukin receptor SHC signaling |
| REAC:R-HSA-912631 | 2.99317612581e-15 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Regulation of signaling by CBL |
| REAC:R-HSA-6811558 | 5.6007014105e-15 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| KEGG:04211 | 6.1854240887e-15 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Longevity regulating pathway |
| REAC:R-HSA-2219528 | 6.90364236364e-15 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-199418 | 1.13488046048e-14 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Negative regulation of the PI3K/AKT network |
| WP:WP3937 | 1.45768417233e-14 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Microglia Pathogen Phagocytosis Pathway |
| KEGG:04960 | 1.780900121e-14 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Aldosterone-regulated sodium reabsorption |
| KEGG:04931 | 3.0045566353e-14 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Insulin resistance |
| REAC:R-HSA-198203 | 3.22089372796e-14 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | PI3K/AKT activation |
| KEGG:04152 | 5.89424514773e-14 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | AMPK signaling pathway |
| KEGG:04068 | 6.694557044e-14 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | FoxO signaling pathway |
| REAC:R-HSA-451927 | 6.99307747711e-14 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Interleukin-2 family signaling |
| KEGG:04973 | 9.27937066778e-14 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Carbohydrate digestion and absorption |
| WP:WP3915 | 1.24296055056e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04910 | 1.29737292302e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Insulin signaling pathway |
| REAC:R-HSA-512988 | 1.79351701411e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:04932 | 2.02394279178e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04140 | 2.02394279178e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Autophagy - animal |
| WP:WP4396 | 2.53962762775e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Nonalcoholic fatty liver disease |
| WP:WP4539 | 2.63343014462e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Synaptic signaling pathways associated with autism spectrum disorder |
| REAC:R-HSA-9027276 | 2.65634488222e-13 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| WP:WP481 | 5.86066722686e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Insulin Signaling |
| KEGG:04929 | 6.2387332223e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | GnRH secretion |
| KEGG:05206 | 6.62740097723e-13 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | MicroRNAs in cancer |
| KEGG:04664 | 7.00225545984e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Fc epsilon RI signaling pathway |
| KEGG:04370 | 7.00225545984e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | VEGF signaling pathway |
| KEGG:05213 | 8.76416412061e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Endometrial cancer |
| WP:WP4205 | 8.89469422453e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | MET in type 1 papillary renal cell carcinoma |
| REAC:R-HSA-1660499 | 9.46118101021e-13 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Synthesis of PIPs at the plasma membrane |
| KEGG:05221 | 1.20890882036e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Acute myeloid leukemia |
| KEGG:05218 | 1.48427437044e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Melanoma |
| KEGG:04917 | 1.48427437044e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Prolactin signaling pathway |
| WP:WP4155 | 1.50638058447e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Endometrial cancer |
| KEGG:05211 | 1.6404190235e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Renal cell carcinoma |
| KEGG:05223 | 1.81001298664e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Non-small cell lung cancer |
| WP:WP1403 | 1.83697062687e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | AMP-activated Protein Kinase (AMPK) Signaling |
| KEGG:05230 | 2.40882594562e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Central carbon metabolism in cancer |
| KEGG:04662 | 2.40882594562e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | B cell receptor signaling pathway |
| KEGG:05214 | 2.64178549425e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Glioma |
| GO:0005942 | 3.10707502205e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | phosphatidylinositol 3-kinase complex |
| WP:WP4255 | 3.21140064694e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Non-small cell lung cancer |
| KEGG:05212 | 3.45616020065e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Pancreatic cancer |
| KEGG:01524 | 3.77013869741e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Platinum drug resistance |
| KEGG:05100 | 4.10752566117e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Bacterial invasion of epithelial cells |
| KEGG:05220 | 4.46969605195e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Chronic myeloid leukemia |
| KEGG:01521 | 4.46969605195e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | EGFR tyrosine kinase inhibitor resistance |
| WP:WP1544 | 5.35273854567e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04012 | 6.70469309503e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | ErbB signaling pathway |
| KEGG:05235 | 7.24789779282e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04914 | 7.82727702424e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Progesterone-mediated oocyte maturation |
| KEGG:04750 | 7.82727702424e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Inflammatory mediator regulation of TRP channels |
| KEGG:05210 | 8.44473162425e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Colorectal cancer |
| WP:WP4263 | 9.23780150709e-12 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Pancreatic adenocarcinoma pathway |
| KEGG:05146 | 1.05456751799e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Amoebiasis |
| WP:WP673 | 1.07027384273e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | ErbB Signaling Pathway |
| KEGG:04620 | 1.13359451572e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Toll-like receptor signaling pathway |
| KEGG:04666 | 1.30650341221e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Fc gamma R-mediated phagocytosis |
| KEGG:04625 | 1.30650341221e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | C-type lectin receptor signaling pathway |
| KEGG:04670 | 1.30650341221e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Leukocyte transendothelial migration |
| KEGG:05142 | 1.30650341221e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Chagas disease (American trypanosomiasis) |
| WP:WP75 | 1.32596197367e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Toll-like Receptor Signaling Pathway |
| KEGG:05231 | 1.40086840294e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Choline metabolism in cancer |
| KEGG:04660 | 1.50084360414e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | T cell receptor signaling pathway |
| KEGG:01522 | 1.50084360414e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Endocrine resistance |
| KEGG:05215 | 1.50084360414e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Prostate cancer |
| KEGG:04933 | 1.60669254903e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04070 | 1.71868793611e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Phosphatidylinositol signaling system |
| KEGG:05222 | 1.71868793611e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Small cell lung cancer |
| KEGG:04668 | 1.83711183861e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | TNF signaling pathway |
| REAC:R-HSA-9006335 | 1.93210566054e-11 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | Signaling by Erythropoietin |
| REAC:R-HSA-1483255 | 1.97686479115e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | PI Metabolism |
| WP:WP4658 | 2.12561514297e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Small cell lung cancer |
| KEGG:04725 | 2.23392045517e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Cholinergic synapse |
| GO:0046854 | 2.55543396121e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | phosphatidylinositol phosphorylation |
| WP:WP3844 | 2.60072531231e-11 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 PIK3CB PIK3R2 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| KEGG:04650 | 2.69968524762e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Natural killer cell mediated cytotoxicity |
| REAC:R-HSA-1257604 | 2.73639785503e-11 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | PIP3 activates AKT signaling |
| KEGG:04066 | 2.87183934328e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | HIF-1 signaling pathway |
| KEGG:04380 | 3.44410920332e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Osteoclast differentiation |
| WP:WP710 | 3.70919404052e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | DNA Damage Response (only ATM dependent) |
| KEGG:04722 | 4.35217112392e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Neurotrophin signaling pathway |
| REAC:R-HSA-109704 | 4.63339138848e-11 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | PI3K Cascade |
| KEGG:04071 | 4.87605412444e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Sphingolipid signaling pathway |
| KEGG:04611 | 5.45143998101e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Platelet activation |
| REAC:R-HSA-114604 | 5.64001821847e-11 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 PIK3CB PIK3R2 | GPVI-mediated activation cascade |
| KEGG:05135 | 5.75967841888e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Yersinia infection |
| KEGG:04919 | 6.0822986954e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Thyroid hormone signaling pathway |
| WP:WP4217 | 8.04835389195e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Ebola Virus Pathway on Host |
| WP:WP1449 | 8.04835389195e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Regulation of toll-like receptor signaling pathway |
| REAC:R-HSA-9006925 | 8.2709479263e-11 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Intracellular signaling by second messengers |
| KEGG:04926 | 8.78984306893e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Relaxin signaling pathway |
| KEGG:04630 | 9.24790760093e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | JAK-STAT signaling pathway |
| KEGG:04915 | 9.72568395042e-11 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Estrogen signaling pathway |
| REAC:R-HSA-112399 | 9.74744542154e-11 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | IRS-mediated signalling |
| KEGG:04550 | 1.0223844367e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling pathways regulating pluripotency of stem cells |
| WP:WP3929 | 1.09030814124e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Chemokine signaling pathway |
| KEGG:04210 | 1.12840917881e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Apoptosis |
| KEGG:05418 | 1.12840917881e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Fluid shear stress and atherosclerosis |
| KEGG:04072 | 1.1847609533e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Phospholipase D signaling pathway |
| GO:0046834 | 1.20970476635e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | lipid phosphorylation |
| KEGG:05162 | 1.30451436039e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Measles |
| KEGG:05224 | 1.43418364817e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Breast cancer |
| KEGG:04062 | 1.43418364817e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Chemokine signaling pathway |
| KEGG:05226 | 1.50293730785e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Gastric cancer |
| REAC:R-HSA-2428924 | 1.59576078137e-10 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 1.59576078137e-10 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | IRS-related events triggered by IGF1R |
| WP:WP51 | 1.59786317118e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Regulation of Actin Cytoskeleton |
| WP:WP4239 | 1.83295088767e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-2404192 | 1.86151218246e-10 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| KEGG:05160 | 1.8892989021e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Hepatitis C |
| REAC:R-HSA-74751 | 2.16151370172e-10 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Insulin receptor signalling cascade |
| WP:WP4566 | 2.49713257939e-10 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 PIK3CB PIK3R2 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:04150 | 2.67777182901e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | mTOR signaling pathway |
| KEGG:04218 | 2.79319699292e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Cellular senescence |
| WP:WP4666 | 2.8347977992e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Hepatitis B infection |
| KEGG:05164 | 3.16462574435e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Influenza A |
| KEGG:05161 | 4.19375504513e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Hepatitis B |
| WP:WP4223 | 4.25621522665e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Ras Signaling |
| WP:WP395 | 4.73139578183e-10 | 0.714285714286 | PIK3CA PIK3CD PIK3R2 IRS2 PIK3R1 | IL-4 Signaling Pathway |
| REAC:R-HSA-5663202 | 4.77532089758e-10 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Diseases of signal transduction |
| KEGG:05225 | 4.89753339168e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Hepatocellular carcinoma |
| REAC:R-HSA-2730905 | 5.99110427193e-10 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Role of LAT2/NTAL/LAB on calcium mobilization |
| KEGG:04360 | 6.13580309067e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Axon guidance |
| KEGG:05167 | 6.13580309067e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Kaposi sarcoma-associated herpesvirus infection |
| GO:0043491 | 6.32254053227e-10 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | protein kinase B signaling |
| KEGG:04024 | 7.35736605291e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | cAMP signaling pathway |
| KEGG:04015 | 8.1829291134e-10 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Rap1 signaling pathway |
| KEGG:05169 | 1.15129674257e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Epstein-Barr virus infection |
| KEGG:04014 | 1.19003527496e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Ras signaling pathway |
| GO:0030258 | 1.26309211976e-09 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | lipid modification |
| KEGG:04810 | 1.3128230984e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Regulation of actin cytoskeleton |
| KEGG:05205 | 1.35602408405e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Proteoglycans in cancer |
| KEGG:05203 | 1.35602408405e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Viral carcinogenesis |
| WP:WP306 | 1.37622018743e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Focal Adhesion |
| KEGG:04510 | 1.4004024066e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Focal adhesion |
| KEGG:05166 | 1.80095998813e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 1.91475506575e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 2.09663280655e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Human cytomegalovirus infection |
| REAC:R-HSA-74752 | 2.86305327923e-09 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Signaling by Insulin receptor |
| WP:WP2037 | 2.92535761409e-09 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Prolactin Signaling Pathway |
| REAC:R-HSA-1483257 | 3.79696873684e-09 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Phospholipid metabolism |
| REAC:R-HSA-210993 | 3.89107916309e-09 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Tie2 Signaling |
| WP:WP2261 | 4.95057419087e-09 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-187037 | 8.57633622434e-09 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-449147 | 8.8687795429e-09 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Signaling by Interleukins |
| WP:WP3932 | 8.92939175905e-09 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-422475 | 9.24271697019e-09 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Axon guidance |
| REAC:R-HSA-389357 | 1.10418282249e-08 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | CD28 dependent PI3K/Akt signaling |
| REAC:R-HSA-2029485 | 1.70443817949e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-2424491 | 1.70443817949e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | DAP12 signaling |
| WP:WP4172 | 1.78103627053e-08 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-373753 | 2.08286616335e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Nephrin family interactions |
| KEGG:04151 | 2.29273539678e-08 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | PI3K-Akt signaling pathway |
| REAC:R-HSA-166520 | 2.64995212275e-08 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Signaling by NTRKs |
| KEGG:05165 | 2.90465117853e-08 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Human papillomavirus infection |
| REAC:R-HSA-2172127 | 3.02466099648e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | DAP12 interactions |
| GO:0006661 | 3.09446048122e-08 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | phosphatidylinositol biosynthetic process |
| GO:0014065 | 3.48664239809e-08 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | phosphatidylinositol 3-kinase signaling |
| WP:WP4564 | 4.19220594924e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R3 PIK3CD | Neural Crest Cell Migration during Development |
| GO:0051897 | 4.91984119721e-08 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | positive regulation of protein kinase B signaling |
| REAC:R-HSA-186763 | 4.99314041853e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Downstream signal transduction |
| REAC:R-HSA-389356 | 5.82439048525e-08 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | CD28 co-stimulation |
| WP:WP4565 | 5.9673145044e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R3 PIK3CD | Neural Crest Cell Migration in Cancer |
| WP:WP524 | 6.66827477594e-08 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3CD | G13 Signaling Pathway |
| WP:WP4262 | 7.2484483389e-08 | 0.714285714286 | PIK3R1 PIK3CA PIK3CD PIK3R3 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-1280215 | 7.43902597063e-08 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Cytokine Signaling in Immune system |
| KEGG:05168 | 9.37614201689e-08 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Herpes simplex virus 1 infection |
| REAC:R-HSA-1266695 | 1.16308570792e-07 | 0.571428571429 | PIK3R1 PIK3R3 IRS2 PIK3R2 | Interleukin-7 signaling |
| GO:0048015 | 1.43380219169e-07 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | phosphatidylinositol-mediated signaling |
| REAC:R-HSA-1433557 | 1.48776903705e-07 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | Signaling by SCF-KIT |
| GO:0048017 | 1.50199138091e-07 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | inositol lipid-mediated signaling |
| GO:0035004 | 1.79134017731e-07 | 0.571428571429 | PIK3CB PIK3CA PIK3R3 PIK3CD | phosphatidylinositol 3-kinase activity |
| GO:0016303 | 1.79134017731e-07 | 0.571428571429 | PIK3CB PIK3CA PIK3R3 PIK3CD | 1-phosphatidylinositol-3-kinase activity |
| GO:0046488 | 2.15124111796e-07 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | phosphatidylinositol metabolic process |
| WP:WP585 | 2.84956376354e-07 | 0.571428571429 | PIK3CD PIK3R2 IRS2 PIK3R1 | Interferon type I signaling pathways |
| GO:0051896 | 2.89682706438e-07 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | regulation of protein kinase B signaling |
| KEGG:05200 | 3.20561002449e-07 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Pathways in cancer |
| REAC:R-HSA-9006934 | 4.59314510627e-07 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-1266738 | 5.65878705755e-07 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Developmental Biology |
| REAC:R-HSA-1643685 | 6.9833363268e-07 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Disease |
| GO:0052742 | 8.53321565671e-07 | 0.571428571429 | PIK3CB PIK3CA PIK3R3 PIK3CD | phosphatidylinositol kinase activity |
| REAC:R-HSA-186797 | 8.95849477501e-07 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Signaling by PDGF |
| REAC:R-HSA-388841 | 8.95849477501e-07 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | Costimulation by the CD28 family |
| GO:0014068 | 1.01702929659e-06 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | positive regulation of phosphatidylinositol 3-kinase signaling |
| GO:0046474 | 1.25243323587e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | glycerophospholipid biosynthetic process |
| REAC:R-HSA-9607240 | 1.86794157977e-06 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | FLT3 Signaling |
| REAC:R-HSA-9009391 | 2.03763943066e-06 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | Extra-nuclear estrogen signaling |
| GO:0008654 | 2.38857038708e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | phospholipid biosynthetic process |
| GO:0045017 | 2.45902527963e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | glycerolipid biosynthetic process |
| REAC:R-HSA-76002 | 2.46608638824e-06 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 PIK3CB PIK3R2 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-449836 | 2.69627544935e-06 | 0.714285714286 | PIK3CB PIK3CA PIK3R2 IRS2 PIK3R1 | Other interleukin signaling |
| GO:0019898 | 3.44871359841e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | extrinsic component of membrane |
| GO:0061695 | 3.64209144037e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-2029480 | 4.46137289934e-06 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0014066 | 5.93698811276e-06 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | regulation of phosphatidylinositol 3-kinase signaling |
| REAC:R-HSA-202424 | 6.87739478972e-06 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Downstream TCR signaling |
| REAC:R-HSA-556833 | 6.87740236204e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Metabolism of lipids |
| REAC:R-HSA-1280218 | 7.47787358855e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Adaptive Immune System |
| REAC:R-HSA-4420097 | 7.52574587436e-06 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | VEGFA-VEGFR2 Pathway |
| GO:0006650 | 8.79787034664e-06 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | glycerophospholipid metabolic process |
| GO:0008286 | 9.3490906024e-06 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | insulin receptor signaling pathway |
| CORUM:3133 | 1.007158685e-05 | 0.285714285714 | PIK3R1 PIK3CA | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| REAC:R-HSA-194138 | 1.05860673156e-05 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Signaling by VEGF |
| REAC:R-HSA-202733 | 1.19447245275e-05 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1500931 | 1.24253268877e-05 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Cell-Cell communication |
| WP:WP4481 | 1.36545401812e-05 | 0.428571428571 | PIK3CB PIK3CD PIK3CA | Resistin as a regulator of inflammation |
| REAC:R-HSA-202403 | 1.44937216864e-05 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | TCR signaling |
| WP:WP244 | 1.83384489647e-05 | 0.428571428571 | PIK3R2 IRS2 PIK3R1 | Alpha 6 Beta 4 signaling pathway |
| REAC:R-HSA-2454202 | 2.30223008303e-05 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fc epsilon receptor (FCERI) signaling |
| GO:0046486 | 3.04983477196e-05 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | glycerolipid metabolic process |
| REAC:R-HSA-416476 | 3.48399314081e-05 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | G alpha (q) signalling events |
| GO:0006644 | 3.54428703858e-05 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | phospholipid metabolic process |
| WP:WP286 | 3.85160299844e-05 | 0.428571428571 | PIK3CD PIK3R2 PIK3R1 | IL-3 Signaling Pathway |
| GO:0044255 | 5.17136010679e-05 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | cellular lipid metabolic process |
| REAC:R-HSA-168256 | 5.2396615138e-05 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Immune System |
| GO:0032869 | 7.32401832121e-05 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | cellular response to insulin stimulus |
| GO:0032868 | 9.35636826405e-05 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | response to insulin |
| GO:0050852 | 0.000107055423967 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | T cell receptor signaling pathway |
| GO:0035005 | 0.000111163123615 | 0.428571428571 | PIK3CB PIK3CD PIK3CA | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| REAC:R-HSA-162582 | 0.0001152718438 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | Signal Transduction |
| WP:WP2032 | 0.000145869877371 | 0.428571428571 | PIK3CA PIK3R2 PIK3R1 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| GO:0036092 | 0.000177825159425 | 0.428571428571 | PIK3CB PIK3CD PIK3CA | phosphatidylinositol-3-phosphate biosynthetic process |
| KEGG:00562 | 0.000187840964122 | 0.428571428571 | PIK3CB PIK3CD PIK3CA | Inositol phosphate metabolism |
| REAC:R-HSA-8939211 | 0.00019368671364 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | ESR-mediated signaling |
| REAC:R-HSA-109582 | 0.000196000309566 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 PIK3CB PIK3R2 | Hemostasis |
| GO:0007411 | 0.000217910906533 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | axon guidance |
| GO:0097485 | 0.000224257230247 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | neuron projection guidance |
| GO:0090407 | 0.000225491563199 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | organophosphate biosynthetic process |
| GO:0006629 | 0.00028100678983 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | lipid metabolic process |
| GO:0050851 | 0.00029621432398 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | antigen receptor-mediated signaling pathway |
| REAC:R-HSA-8851907 | 0.000316419251483 | 0.285714285714 | PIK3R1 PIK3CA | MET activates PI3K/AKT signaling |
| REAC:R-HSA-9028335 | 0.000316419251483 | 0.285714285714 | PIK3R1 PIK3CA | Activated NTRK2 signals through PI3K |
| GO:0071375 | 0.000375722607179 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | cellular response to peptide hormone stimulus |
| REAC:R-HSA-9006931 | 0.000395752710572 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-9603381 | 0.000474522632096 | 0.285714285714 | PIK3R1 PIK3CA | Activated NTRK3 signals through PI3K |
| REAC:R-HSA-1250342 | 0.000474522632096 | 0.285714285714 | PIK3R1 PIK3CA | PI3K events in ERBB4 signaling |
| GO:0007169 | 0.000545064820292 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0008610 | 0.000571114136273 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | lipid biosynthetic process |
| GO:0043434 | 0.000688885314626 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | response to peptide hormone |
| GO:0046935 | 0.000698035893352 | 0.428571428571 | PIK3R1 PIK3R3 PIK3R2 | 1-phosphatidylinositol-3-kinase regulator activity |
| GO:0040011 | 0.000886250502029 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | locomotion |
| GO:0016307 | 0.000907263777246 | 0.428571428571 | PIK3CB PIK3CD PIK3CA | phosphatidylinositol phosphate kinase activity |
| WP:WP3935 | 0.000914055366538 | 0.285714285714 | PIK3R3 IRS2 | Leptin Insulin Overlap |
| GO:1901653 | 0.000918945268793 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | cellular response to peptide |
| GO:0002433 | 0.00102597538092 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0038096 | 0.00102597538092 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0038094 | 0.00102597538092 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fc-gamma receptor signaling pathway |
| GO:0048010 | 0.00102597538092 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | vascular endothelial growth factor receptor signaling pathway |
| REAC:R-HSA-1963642 | 0.00113808966034 | 0.285714285714 | PIK3R1 PIK3CA | PI3K events in ERBB2 signaling |
| REAC:R-HSA-5654710 | 0.00113808966034 | 0.285714285714 | PIK3R1 PIK3CA | PI-3K cascade:FGFR3 |
| REAC:R-HSA-8853334 | 0.00113808966034 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR3 fusions in cancer |
| GO:0002431 | 0.00114194554293 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fc receptor mediated stimulatory signaling pathway |
| GO:0035014 | 0.00115446662879 | 0.428571428571 | PIK3R1 PIK3R3 PIK3R2 | phosphatidylinositol 3-kinase regulator activity |
| WP:WP22 | 0.00120480805051 | 0.285714285714 | PIK3R2 PIK3R1 | IL-9 Signaling Pathway |
| GO:0050900 | 0.00130814625966 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | leukocyte migration |
| WP:WP2380 | 0.00134980840198 | 0.428571428571 | PIK3R2 IRS2 PIK3R1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-5655291 | 0.00142229359687 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR4 in disease |
| REAC:R-HSA-180292 | 0.00173796966748 | 0.285714285714 | PIK3R1 PIK3CA | GAB1 signalosome |
| GO:1901652 | 0.0018532045628 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | response to peptide |
| REAC:R-HSA-5654689 | 0.00208509668734 | 0.285714285714 | PIK3R1 PIK3CA | PI-3K cascade:FGFR1 |
| REAC:R-HSA-5654720 | 0.00208509668734 | 0.285714285714 | PIK3R1 PIK3CA | PI-3K cascade:FGFR4 |
| GO:0007409 | 0.00218643526384 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | axonogenesis |
| WP:WP205 | 0.00231614132512 | 0.285714285714 | PIK3R2 PIK3R1 | IL-7 Signaling Pathway |
| GO:0002429 | 0.00239120915924 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | immune response-activating cell surface receptor signaling pathway |
| REAC:R-HSA-5637812 | 0.00246365348013 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-5637810 | 0.00246365348013 | 0.285714285714 | PIK3R1 PIK3CA | Constitutive Signaling by EGFRvIII |
| REAC:R-HSA-5654695 | 0.00246365348013 | 0.285714285714 | PIK3R1 PIK3CA | PI-3K cascade:FGFR2 |
| REAC:R-HSA-5654708 | 0.00287361887808 | 0.285714285714 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-8853338 | 0.00287361887808 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR3 point mutants in cancer |
| REAC:R-HSA-5655332 | 0.00287361887808 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR3 in disease |
| REAC:R-HSA-9034015 | 0.00287361887808 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by NTRK3 (TRKC) |
| GO:0061564 | 0.00289568484403 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | axon development |
| GO:0006928 | 0.00305651191569 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | movement of cell or subcellular component |
| GO:1902533 | 0.00314424373866 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | positive regulation of intracellular signal transduction |
| GO:0002768 | 0.00342473107509 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | immune response-regulating cell surface receptor signaling pathway |
| GO:1990234 | 0.00351782066073 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | transferase complex |
| GO:0038095 | 0.00357147263372 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fc-epsilon receptor signaling pathway |
| REAC:R-HSA-1839117 | 0.00378769086114 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by cytosolic FGFR1 fusion mutants |
| GO:0007167 | 0.00386206265228 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | enzyme linked receptor protein signaling pathway |
| WP:WP3972 | 0.00406441658231 | 0.285714285714 | PIK3R1 PIK3CA | PDGFR-beta pathway |
| REAC:R-HSA-1430728 | 0.00415508232387 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | Metabolism |
| GO:0002684 | 0.00419886214655 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | positive regulation of immune system process |
| REAC:R-HSA-1236382 | 0.00429175515342 | 0.285714285714 | PIK3R1 PIK3CA | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| REAC:R-HSA-5654716 | 0.00429175515342 | 0.285714285714 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-5637815 | 0.00429175515342 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-5654696 | 0.00482714346521 | 0.285714285714 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR2 |
| REAC:R-HSA-1643713 | 0.00539383467143 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by EGFR in Cancer |
| WP:WP3888 | 0.00558908974541 | 0.428571428571 | PIK3CA PIK3R2 PIK3R1 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-5654687 | 0.00599180765553 | 0.285714285714 | PIK3R1 PIK3CA | Downstream signaling of activated FGFR1 |
| REAC:R-HSA-9006115 | 0.00599180765553 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by NTRK2 (TRKB) |
| WP:WP2828 | 0.00629697152788 | 0.285714285714 | PIK3R2 PIK3R1 | Bladder Cancer |
| GO:0048667 | 0.00654925967096 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | cell morphogenesis involved in neuron differentiation |
| HPA:056010_22 | 0.00676251068518 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | tonsil; germinal center cells[Approved,Medium] |
| HPA:056020_22 | 0.00682207122721 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | tonsil; non-germinal center cells[Approved,Medium] |
| GO:0019637 | 0.00682589302287 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | organophosphate metabolic process |
| WP:WP127 | 0.00702347294811 | 0.285714285714 | PIK3R2 PIK3R1 | IL-5 Signaling Pathway |
| HPA:004030_22 | 0.00718859892272 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | breast; myoepithelial cells[Approved,Medium] |
| WP:WP2332 | 0.00740146173377 | 0.285714285714 | PIK3R2 PIK3R1 | Interleukin-11 Signaling Pathway |
| WP:WP364 | 0.00859430044807 | 0.285714285714 | PIK3R2 PIK3R1 | IL-6 signaling pathway |
| REAC:R-HSA-983695 | 0.00869609533822 | 0.285714285714 | PIK3R1 PIK3CD | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| REAC:R-HSA-1839124 | 0.00869609533822 | 0.285714285714 | PIK3R1 PIK3CA | FGFR1 mutant receptor activation |
| REAC:R-HSA-388396 | 0.00903420497711 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | GPCR downstream signalling |
| GO:0005943 | 0.00946729163895 | 0.285714285714 | PIK3R1 PIK3CA | phosphatidylinositol 3-kinase complex, class IA |
| GO:0071417 | 0.00953662011938 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | cellular response to organonitrogen compound |
| GO:0042330 | 0.00979493405468 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | taxis |
| GO:0006935 | 0.00979493405468 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | chemotaxis |
| GO:0016310 | 0.0100383435656 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | phosphorylation |
| REAC:R-HSA-5654741 | 0.0118992043595 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR3 |
| GO:0071310 | 0.0121257270998 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | cellular response to organic substance |
| REAC:R-HSA-372790 | 0.0124590407181 | 0.571428571429 | PIK3R1 PIK3CA PIK3R3 PIK3R2 | Signaling by GPCR |
| MIRNA:hsa-miR-7-5p | 0.012587639294 | 0.571428571429 | PIK3CB PIK3R3 IRS2 PIK3CD | hsa-miR-7-5p |
| GO:0098796 | 0.0126459869113 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | membrane protein complex |
| WP:WP195 | 0.0127011112483 | 0.285714285714 | PIK3R2 PIK3R1 | IL-1 signaling pathway |
| GO:0043551 | 0.0128352677703 | 0.428571428571 | PIK3R1 PIK3R3 PIK3R2 | regulation of phosphatidylinositol 3-kinase activity |
| WP:WP2018 | 0.01320619581 | 0.285714285714 | PIK3R2 PIK3R1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| GO:0048812 | 0.0133528244508 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | neuron projection morphogenesis |
| REAC:R-HSA-5654743 | 0.0136873957341 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR4 |
| REAC:R-HSA-5655302 | 0.0146280770201 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR1 in disease |
| GO:0032870 | 0.0149253914757 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | cellular response to hormone stimulus |
| GO:0120039 | 0.0152940808592 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | plasma membrane bounded cell projection morphogenesis |
| WP:WP304 | 0.0153237691065 | 0.285714285714 | PIK3R2 PIK3R1 | Kit receptor signaling pathway |
| WP:WP61 | 0.0153237691065 | 0.285714285714 | PIK3R2 PIK3R1 | Notch Signaling Pathway |
| GO:0002757 | 0.0156699851117 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | immune response-activating signal transduction |
| GO:0001784 | 0.0156741996846 | 0.428571428571 | PIK3R1 PIK3R3 PIK3R2 | phosphotyrosine residue binding |
| GO:0048858 | 0.0158606753809 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | cell projection morphogenesis |
| GO:1901699 | 0.0164438565445 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | cellular response to nitrogen compound |
| GO:0016477 | 0.0174443467225 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | cell migration |
| REAC:R-HSA-5655253 | 0.0176362111261 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR2 in disease |
| GO:0032990 | 0.0180828342295 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | cell part morphogenesis |
| REAC:R-HSA-5654736 | 0.0197964991178 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR1 |
| GO:0002764 | 0.0203116562364 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | immune response-regulating signaling pathway |
| WP:WP3303 | 0.0206553279975 | 0.285714285714 | PIK3R1 PIK3CA | RAC1/PAK1/p38/MMP2 Pathway |
| HP:0200043 | 0.0218481766952 | 0.285714285714 | PIK3R1 PIK3CA | Verrucae |
| GO:0038093 | 0.0230102688001 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | Fc receptor signaling pathway |
| GO:0000904 | 0.0257043347096 | 0.714285714286 | PIK3CB PIK3CA PIK3R1 IRS2 PIK3CD | cell morphogenesis involved in differentiation |
| HP:0001355 | 0.0265508883611 | 0.285714285714 | PIK3R2 PIK3CA | Megalencephaly |
| GO:0043550 | 0.026626530587 | 0.428571428571 | PIK3R1 PIK3R3 PIK3R2 | regulation of lipid kinase activity |
| WP:WP2034 | 0.0267680695584 | 0.285714285714 | PIK3R2 PIK3R1 | Leptin signaling pathway |
| REAC:R-HSA-1227986 | 0.0270188709739 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by ERBB2 |
| REAC:R-HSA-177929 | 0.0283305162673 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by EGFR |
| GO:0033031 | 0.0283955176165 | 0.285714285714 | PIK3CB PIK3CD | positive regulation of neutrophil apoptotic process |
| GO:0033029 | 0.0283955176165 | 0.285714285714 | PIK3CB PIK3CD | regulation of neutrophil apoptotic process |
| GO:0097651 | 0.0283955176165 | 0.285714285714 | PIK3R1 PIK3CA | phosphatidylinositol 3-kinase complex, class I |
| WP:WP69 | 0.0289784167112 | 0.285714285714 | PIK3R2 PIK3R1 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| HPA:039010_22 | 0.0293225217065 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | salivary gland; glandular cells[Approved,Medium] |
| HP:0002721 | 0.029622117541 | 0.428571428571 | PIK3CA PIK3R1 PIK3CD | Immunodeficiency |
| GO:0009725 | 0.0315117314699 | 0.714285714286 | PIK3R1 PIK3CA PIK3R3 IRS2 PIK3R2 | response to hormone |
| GO:0002253 | 0.0321790888726 | 0.714285714286 | PIK3CB PIK3CA PIK3CD PIK3R2 PIK3R1 | activation of immune response |
| REAC:R-HSA-1236394 | 0.0324500337431 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by ERBB4 |
| GO:0007166 | 0.0325462707004 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | cell surface receptor signaling pathway |
| GO:0045309 | 0.0336257766492 | 0.428571428571 | PIK3R1 PIK3R3 PIK3R2 | protein phosphorylated amino acid binding |
| GO:0002682 | 0.0337325846401 | 0.857142857143 | PIK3CD PIK3R2 PIK3R1 PIK3CB PIK3CA IRS2 | regulation of immune system process |
| GO:0048870 | 0.033929718028 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | cell motility |
| GO:0051674 | 0.033929718028 | 0.857142857143 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | localization of cell |
| GO:0010033 | 0.0340990636841 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | response to organic substance |
| GO:0035556 | 0.0364825715723 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | intracellular signal transduction |
| WP:WP23 | 0.0378182063894 | 0.285714285714 | PIK3R2 PIK3R1 | B Cell Receptor Signaling Pathway |
| WP:WP138 | 0.0378182063894 | 0.285714285714 | PIK3R2 PIK3R1 | Androgen receptor signaling pathway |
| WP:000000 | 0.0394625231882 | 1.0 | PIK3CD PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA IRS2 | WIKIPATHWAYS |
| GO:2000106 | 0.0417514312642 | 0.428571428571 | PIK3CB PIK3CD IRS2 | regulation of leukocyte apoptotic process |
| REAC:R-HSA-1226099 | 0.0431362871916 | 0.285714285714 | PIK3R1 PIK3CA | Signaling by FGFR in disease |
| GO:0006909 | 0.0445064353059 | 0.571428571429 | PIK3CB PIK3CA PIK3R2 PIK3R1 | phagocytosis |
| HP:0100658 | 0.0465920925289 | 0.285714285714 | PIK3R1 PIK3CD | Cellulitis |
| WP:WP3931 | 0.0468514080623 | 0.285714285714 | PIK3R2 PIK3CD | ESC Pluripotency Pathways |
| HPA:011030_21 | 0.049204378171 | 0.857142857143 | IRS2 PIK3R3 PIK3R1 PIK3R2 PIK3CB PIK3CA | colon; peripheral nerve/ganglion[Approved,Low] |
| CORUM:7361 | 0.0499886427319 | 0.142857142857 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIK3R2 | PIK3R1 | 1.0 | 0.949 | bioplex (PIK3R2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3R1 | PIK3CB | 0.981 | 0.896 | hein_WMM bioplex_WMM hein (PIK3R1) fraction |
| PIK3R3 | PIK3CA | 0.917 | 0.84 | hein_WMM bioplex (PIK3R3) bioplex_WMM hein (PIK3CA) |
| PIK3R3 | IRS2 | 0.885 | 0.817 | bioplex (PIK3R3) bioplex_WMM |
| PIK3R2 | PIK3R3 | 0.878 | 0.812 | hein_WMM bioplex (PIK3R2,PIK3R3) bioplex_WMM gupta_WMM |
| PIK3R3 | PIK3CB | 0.699 | 0.721 | bioplex (PIK3R3) bioplex_WMM |
| PIK3R3 | PIK3CD | 0.473 | 0.608 | bioplex (PIK3R3) bioplex_WMM |
| PIK3R3 | PIK3R1 | 0.224 | 0.466 | bioplex (PIK3R3) bioplex_WMM gupta_WMM |
| PIK3R1 | PIK3CA | 0.174 | 0.434 | hein_WMM bioplex_WMM hein (PIK3R1) |
| PIK3R2 | PIK3CA | 0.164 | 0.42 | hein_WMM bioplex_WMM hein (PIK3CA) |
| PIK3R2 | PIK3CB | 0.127 | 0.398 | bioplex (PIK3R2) bioplex_WMM |
| PIK3R1 | PIK3CD | 0.022 | 0.2 | hein_WMM bioplex_WMM hein (PIK3R1) |
| PIK3CA | PIK3CB | 0.02 | 0.189 | hein_WMM bioplex_WMM WMM_only |
| PIK3R1 | IRS2 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM hein (PIK3R1) |
| PIK3CD | IRS2 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| PIK3CD | PIK3CB | 0.009 | 0.108 | hein_WMM bioplex_WMM WMM_only |
| PIK3CD | PIK3CA | 0.009 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| PIK3CB | IRS2 | 0.008 | 0.086 | hein_WMM bioplex_WMM WMM_only |
| PIK3CA | IRS2 | 0.008 | 0.06 | hein_WMM bioplex_WMM WMM_only |
| PIK3R2 | IRS2 | 0.007 | 0.01 | bioplex_WMM youn_WMM WMM_only |
| PIK3R2 | PIK3CD | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00730 has an average edge precision of 0.398 which is ranked 3346 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PIK3R1 | HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 |
| PIK3CB | HuMAP2_00730 HuMAP2_02534 HuMAP2_05290 |
| PIK3R3 | HuMAP2_00730 HuMAP2_02534 HuMAP2_06506 |
| PIK3R2 | HuMAP2_00324 HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 HuMAP2_06494 |
| PIK3CD | HuMAP2_00730 HuMAP2_02534 |
| PIK3CA | HuMAP2_00730 HuMAP2_02534 HuMAP2_06506 |
| IRS2 | HuMAP2_00730 HuMAP2_02534 HuMAP2_06506 |