hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00731
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLR3D | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) | UniProt NCBI |
| POLR3H | DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9) | UniProt NCBI |
| CRCP | DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) | UniProt NCBI |
| POLR3B | DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | UniProt NCBI |
| POLR3A | DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160) | UniProt NCBI |
| POLR3F | DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) | UniProt NCBI |
| POLR3G | DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32) | UniProt NCBI |
| POLR3C | DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62) | UniProt NCBI |
| POLR3GL | DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) (RNA polymerase III 32 kDa beta subunit) (RPC32-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73780 | 9.76836883175e-26 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Chain Elongation |
| REAC:R-HSA-73980 | 1.64183737672e-24 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Transcription Termination |
| REAC:R-HSA-76066 | 9.41642024884e-24 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| REAC:R-HSA-76061 | 1.38768298404e-23 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| REAC:R-HSA-76071 | 1.38768298404e-23 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| GO:0005666 | 2.45186057677e-23 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA polymerase III complex |
| REAC:R-HSA-76046 | 1.89145677102e-22 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Transcription Initiation |
| REAC:R-HSA-749476 | 7.03884237094e-22 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Abortive And Retractive Initiation |
| REAC:R-HSA-74158 | 7.03884237094e-22 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA Polymerase III Transcription |
| KEGG:03020 | 4.49124062627e-20 | 0.888888888889 | POLR3F POLR3G POLR3GL POLR3D POLR3H POLR3A POLR3B POLR3C | RNA polymerase |
| REAC:R-HSA-1834949 | 4.75513623012e-20 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | Cytosolic sensors of pathogen-associated DNA |
| GO:0032481 | 1.38884560728e-17 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | positive regulation of type I interferon production |
| KEGG:04623 | 1.4683915141e-17 | 0.888888888889 | POLR3F POLR3G POLR3GL POLR3D POLR3H POLR3A POLR3B POLR3C | Cytosolic DNA-sensing pathway |
| WP:WP4655 | 6.62180076683e-17 | 0.888888888889 | POLR3F POLR3G POLR3GL POLR3D POLR3H POLR3A POLR3B POLR3C | Cytosolic DNA-sensing pathway |
| WP:WP4022 | 2.33550618413e-16 | 0.888888888889 | POLR3F POLR3G POLR3GL POLR3D POLR3H POLR3A POLR3B POLR3C | Pyrimidine metabolism |
| GO:0003899 | 2.89323459719e-16 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | DNA-directed 5'-3' RNA polymerase activity |
| GO:0034062 | 5.76210246252e-16 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | 5'-3' RNA polymerase activity |
| GO:0097747 | 5.76210246252e-16 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | RNA polymerase activity |
| GO:0001056 | 6.38561078748e-16 | 0.777777777778 | POLR3D POLR3F CRCP POLR3H POLR3A POLR3B POLR3C | RNA polymerase III activity |
| GO:0055029 | 6.53834498549e-16 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 7.20703935901e-16 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | DNA-directed RNA polymerase complex |
| GO:0030880 | 9.5927749463e-16 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | RNA polymerase complex |
| GO:0032479 | 1.15503468323e-15 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | regulation of type I interferon production |
| GO:0032606 | 1.26562311034e-15 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | type I interferon production |
| GO:0061695 | 1.60932266854e-12 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | transferase complex, transferring phosphorus-containing groups |
| GO:0016779 | 3.2941028349e-12 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | nucleotidyltransferase activity |
| GO:0001819 | 1.89362109106e-11 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | positive regulation of cytokine production |
| GO:0032728 | 2.79105691639e-11 | 0.666666666667 | POLR3F POLR3G POLR3D POLR3C POLR3A POLR3B | positive regulation of interferon-beta production |
| GO:0032648 | 3.71142228382e-10 | 0.666666666667 | POLR3F POLR3G POLR3D POLR3C POLR3A POLR3B | regulation of interferon-beta production |
| GO:0032608 | 5.37330376739e-10 | 0.666666666667 | POLR3F POLR3G POLR3D POLR3C POLR3A POLR3B | interferon-beta production |
| GO:0001817 | 7.59025165973e-10 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | regulation of cytokine production |
| GO:0001816 | 1.5850655075e-09 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | cytokine production |
| REAC:R-HSA-168249 | 1.99935932968e-09 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | Innate Immune System |
| GO:0006383 | 2.57952263146e-09 | 0.666666666667 | POLR3F POLR3GL POLR3G CRCP POLR3H POLR3C | transcription by RNA polymerase III |
| GO:0140098 | 1.35110116899e-08 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | catalytic activity, acting on RNA |
| REAC:R-HSA-74160 | 5.17879071979e-08 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | Gene expression (Transcription) |
| GO:1990234 | 5.25719457291e-08 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | transferase complex |
| REAC:R-HSA-168256 | 8.61086407311e-07 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | Immune System |
| GO:0051240 | 1.35257420493e-06 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | positive regulation of multicellular organismal process |
| GO:1902494 | 6.70061170383e-06 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | catalytic complex |
| GO:0016772 | 2.22971764872e-05 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | transferase activity, transferring phosphorus-containing groups |
| WP:WP405 | 9.62794620444e-05 | 0.333333333333 | POLR3D POLR3H POLR3B | Eukaryotic Transcription Initiation |
| GO:0051239 | 0.000479061894703 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | regulation of multicellular organismal process |
| WP:000000 | 0.00566194757866 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | WIKIPATHWAYS |
| GO:0045087 | 0.0112938665564 | 0.666666666667 | POLR3F POLR3G POLR3D POLR3C POLR3A POLR3B | innate immune response |
| GO:0006359 | 0.0116809984418 | 0.333333333333 | POLR3F POLR3G POLR3C | regulation of transcription by RNA polymerase III |
| GO:0045089 | 0.0182937634408 | 0.555555555556 | POLR3D POLR3G POLR3B POLR3C POLR3F | positive regulation of innate immune response |
| GO:0016740 | 0.0198541477682 | 0.888888888889 | POLR3D POLR3F POLR3G CRCP POLR3H POLR3A POLR3B POLR3C | transferase activity |
| GO:0002833 | 0.021900395194 | 0.555555555556 | POLR3D POLR3G POLR3B POLR3C POLR3F | positive regulation of response to biotic stimulus |
| GO:0098542 | 0.0289981625691 | 0.666666666667 | POLR3F POLR3G POLR3D POLR3C POLR3A POLR3B | defense response to other organism |
| HP:0002127 | 0.0343154638255 | 0.222222222222 | POLR3A POLR3B | Abnormal upper motor neuron morphology |
| GO:0045088 | 0.0411850424326 | 0.555555555556 | POLR3D POLR3G POLR3B POLR3C POLR3F | regulation of innate immune response |
| GO:0031349 | 0.0435602461787 | 0.555555555556 | POLR3D POLR3G POLR3B POLR3C POLR3F | positive regulation of defense response |
| GO:0005654 | 0.0467384203064 | 1.0 | POLR3D POLR3F POLR3G POLR3GL CRCP POLR3H POLR3A POLR3B POLR3C | nucleoplasm |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| 101060521 | POLR3F | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3D | POLR3F | 1.0 | 0.949 | hein_WMM bioplex (POLR3D) bioplex_WMM Malo fraction |
| POLR3H | POLR3C | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3D | POLR3C | 1.0 | 0.949 | hein_WMM bioplex (POLR3D) bioplex_WMM Malo fraction |
| 101060521 | POLR3C | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3A | POLR3F | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3H | POLR3F | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3D | POLR3G | 1.0 | 0.949 | hein_WMM bioplex (POLR3D) bioplex_WMM Malo fraction |
| POLR3H | POLR3B | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| POLR3B | POLR3G | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3H | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3B | POLR3F | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3A | POLR3G | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3B | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| 101060521 | POLR3G | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3H | POLR3G | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3A | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| CRCP | POLR3C | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| CRCP | POLR3F | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3H | POLR3A | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| POLR3B | POLR3C | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| POLR3G | POLR3C | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3D | POLR3A | 0.998 | 0.941 | hein_WMM bioplex (POLR3D) bioplex_WMM Guru Malo fraction |
| POLR3A | POLR3C | 0.998 | 0.94 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| POLR3B | POLR3A | 0.996 | 0.927 | hein_WMM bioplex_WMM Guru Malo fraction |
| POLR3F | POLR3G | 0.995 | 0.923 | hein_WMM bioplex_WMM Guru Malo fraction |
| 101060521 | CRCP | 0.992 | 0.912 | hein_WMM hein (101060521) Malo fraction |
| POLR3D | POLR3B | 0.991 | 0.91 | hein_WMM bioplex (POLR3D) bioplex_WMM Guru Malo fraction |
| CRCP | POLR3B | 0.986 | 0.901 | hein_WMM bioplex_WMM Malo fraction |
| CRCP | POLR3D | 0.972 | 0.886 | hein_WMM bioplex (POLR3D) bioplex_WMM |
| POLR3D | POLR3H | 0.971 | 0.882 | hein_WMM bioplex (POLR3D) bioplex_WMM |
| POLR3F | POLR3GL | 0.938 | 0.85 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| CRCP | POLR3A | 0.917 | 0.84 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3D | 0.881 | 0.816 | hein_WMM hein (101060521) Malo fraction |
| POLR3C | POLR3GL | 0.55 | 0.643 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| POLR3H | POLR3GL | 0.459 | 0.598 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| POLR3D | POLR3GL | 0.42 | 0.573 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| POLR3B | POLR3GL | 0.286 | 0.489 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| POLR3F | POLR3C | 0.189 | 0.441 | hein_WMM bioplex_WMM Malo fraction |
| CRCP | POLR3GL | 0.102 | 0.365 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| POLR3A | POLR3GL | 0.094 | 0.357 | hein_WMM bioplex (POLR3GL) bioplex_WMM |
| 101060521 | POLR3GL | 0.061 | 0.338 | hein_WMM hein (101060521) |
| CRCP | POLR3H | 0.019 | 0.182 | hein_WMM bioplex_WMM WMM_only |
| CRCP | POLR3G | 0.017 | 0.168 | hein_WMM bioplex_WMM WMM_only |
| POLR3G | POLR3GL | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00731 has an average edge precision of 0.798 which is ranked 930 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLR3D | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3H | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| CRCP | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3B | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3A | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3F | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3G | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3C | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3GL | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 |