hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00744
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MTOR | Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) | UniProt NCBI |
| MLST8 | Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2970 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTORC1 complex |
| CORUM:1895 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTOR complex (MTOR, RICTOR, MLST8) |
| CORUM:2969 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTORC2 complex |
| CORUM:1893 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTOR complex (MTOR, RICTOR, MLST8) |
| CORUM:3980 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTOR complex (MTOR, RAPTOR, MLST8) |
| CORUM:2990 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTOR complex (MTOR, RAPTOR, MLST8) |
| CORUM:1897 | 5.02777038712e-06 | 1.0 | MLST8 MTOR | mTOR complex (MTOR, RAPTOR, MLST8) |
| CORUM:3979 | 1.00555407742e-05 | 1.0 | MLST8 MTOR | mTORC2 complex |
| KEGG:04136 | 6.7842358023e-05 | 1.0 | MLST8 MTOR | Autophagy - other |
| WP:WP1471 | 0.000221685892372 | 1.0 | MLST8 MTOR | Target Of Rapamycin (TOR) Signaling |
| REAC:R-HSA-389357 | 0.000286582912066 | 1.0 | MLST8 MTOR | CD28 dependent PI3K/Akt signaling |
| WP:WP4577 | 0.000336440942541 | 1.0 | MLST8 MTOR | Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway |
| REAC:R-HSA-166208 | 0.000387138319809 | 1.0 | MLST8 MTOR | mTORC1-mediated signalling |
| REAC:R-HSA-3371571 | 0.000424008635981 | 1.0 | MLST8 MTOR | HSF1-dependent transactivation |
| REAC:R-HSA-5674400 | 0.000502777038712 | 1.0 | MLST8 MTOR | Constitutive Signaling by AKT1 E17K in Cancer |
| WP:WP585 | 0.000533163885688 | 1.0 | MLST8 MTOR | Interferon type I signaling pathways |
| REAC:R-HSA-5218920 | 0.000544675125272 | 1.0 | MLST8 MTOR | VEGFR2 mediated vascular permeability |
| WP:WP4538 | 0.000573775250846 | 1.0 | MLST8 MTOR | Regulatory circuits of the STAT3 signaling pathway |
| REAC:R-HSA-389356 | 0.000633499068778 | 1.0 | MLST8 MTOR | CD28 co-stimulation |
| REAC:R-HSA-380972 | 0.000633499068778 | 1.0 | MLST8 MTOR | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-6804757 | 0.000997174460113 | 1.0 | MLST8 MTOR | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.0010558317813 | 1.0 | MLST8 MTOR | Regulation of TP53 Expression and Degradation |
| WP:WP4018 | 0.00117735700823 | 1.0 | MLST8 MTOR | Pathways in clear cell renal cell carcinoma |
| REAC:R-HSA-165159 | 0.00124185928562 | 1.0 | MLST8 MTOR | mTOR signalling |
| KEGG:04140 | 0.00128068864242 | 1.0 | MLST8 MTOR | Autophagy - animal |
| WP:WP615 | 0.00145902849501 | 1.0 | MLST8 MTOR | Senescence and Autophagy in Cancer |
| KEGG:04150 | 0.00150216111442 | 1.0 | MLST8 MTOR | mTOR signaling pathway |
| WP:WP4321 | 0.001844277592 | 1.0 | MLST8 MTOR | Thermogenesis |
| REAC:R-HSA-388841 | 0.00239824647466 | 1.0 | MLST8 MTOR | Costimulation by the CD28 family |
| WP:WP4549 | 0.00244227062941 | 1.0 | MLST8 MTOR | Fragile X Syndrome |
| REAC:R-HSA-8943724 | 0.00267477384595 | 1.0 | MLST8 MTOR | Regulation of PTEN gene transcription |
| WP:WP3915 | 0.00284130523568 | 1.0 | MLST8 MTOR | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04714 | 0.00317122901933 | 1.0 | MLST8 MTOR | Thermogenesis |
| REAC:R-HSA-2219528 | 0.004164669804 | 1.0 | MLST8 MTOR | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-5628897 | 0.0052959181411 | 1.0 | MLST8 MTOR | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-3371556 | 0.00598304676068 | 1.0 | MLST8 MTOR | Cellular response to heat stress |
| REAC:R-HSA-1632852 | 0.00626962967274 | 1.0 | MLST8 MTOR | Macroautophagy |
| KEGG:04151 | 0.00654350485448 | 1.0 | MLST8 MTOR | PI3K-Akt signaling pathway |
| REAC:R-HSA-4420097 | 0.00686290657842 | 1.0 | MLST8 MTOR | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00812990471598 | 1.0 | MLST8 MTOR | Signaling by VEGF |
| REAC:R-HSA-9612973 | 0.00880362594785 | 1.0 | MLST8 MTOR | Autophagy |
| WP:WP3888 | 0.00889388896944 | 1.0 | MLST8 MTOR | VEGFA-VEGFR2 Signaling Pathway |
| GO:0031931 | 0.00946729163895 | 1.0 | MLST8 MTOR | TORC1 complex |
| WP:WP3932 | 0.0121610546673 | 1.0 | MLST8 MTOR | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | MLST8 MTOR | PTEN Regulation |
| WP:WP4172 | 0.015291110435 | 1.0 | MLST8 MTOR | PI3K-Akt Signaling Pathway |
| GO:0031932 | 0.020287053512 | 1.0 | MLST8 MTOR | TORC2 complex |
| REAC:R-HSA-5633007 | 0.0205233587202 | 1.0 | MLST8 MTOR | Regulation of TP53 Activity |
| WP:WP4186 | 0.0332875339197 | 0.5 | MTOR | Somatroph axis (GH) and its relationship to dietary restriction and aging |
| WP:WP4191 | 0.0332875339197 | 0.5 | MTOR | Caloric restriction and aging |
| GO:0038201 | 0.0351642260875 | 1.0 | MLST8 MTOR | TOR complex |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | MLST8 MTOR | PIP3 activates AKT signaling |
| WP:WP3634 | 0.0443803979089 | 0.5 | MTOR | Insulin signalling in human adipocytes (normal condition) |
| WP:WP3635 | 0.0443803979089 | 0.5 | MTOR | Insulin signalling in human adipocytes (diabetic condition) |
| HP:0012650 | 0.0497341708567 | 0.5 | MTOR | Perisylvian polymicrogyria |
| CORUM:2991 | 0.0499173803268 | 0.5 | MTOR | mTOR complex (MTOR, RAPTOR) |
| CORUM:2985 | 0.0499173803268 | 0.5 | MTOR | mTOR complex (MTOR, RAPTOR) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MLST8 | MTOR | 0.995 | 0.923 | bioplex (MLST8) bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_00744 has an average edge precision of 0.923 which is ranked 461 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MTOR | HuMAP2_00744 HuMAP2_05243 HuMAP2_05717 |
| MLST8 | HuMAP2_00744 HuMAP2_05243 HuMAP2_05717 |