hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00752
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBM8A | RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A) | UniProt NCBI |
| FAF1 | FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) | UniProt NCBI |
| BHLHA15 | Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1) | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | UniProt NCBI |
| MAGOHB | Protein mago nashi homolog 2 | UniProt NCBI |
| CASC3 | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | UniProt NCBI |
| SAP18 | Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18) | UniProt NCBI |
| SDE2 | Replication stress response regulator SDE2 | UniProt NCBI |
| MAGOH | Protein mago nashi homolog | UniProt NCBI |
| CCDC9 | Coiled-coil domain-containing protein 9 | UniProt NCBI |
| NKTR | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035145 | 4.12258528826e-11 | 0.545454545455 | PYM1 CASC3 MAGOHB MAGOH SAP18 RBM8A | exon-exon junction complex |
| CORUM:755 | 5.44486299702e-11 | 0.363636363636 | CASC3 PYM1 MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM) |
| KEGG:03015 | 7.27210487374e-10 | 0.545454545455 | PYM1 CASC3 MAGOHB MAGOH SAP18 RBM8A | mRNA surveillance pathway |
| KEGG:03013 | 2.12450708967e-08 | 0.545454545455 | PYM1 CASC3 MAGOHB MAGOH SAP18 RBM8A | RNA transport |
| CORUM:769 | 8.10772781726e-08 | 0.272727272727 | CASC3 MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:754 | 8.10772781726e-08 | 0.272727272727 | CASC3 MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14) |
| CORUM:744 | 8.10772781726e-08 | 0.272727272727 | CASC3 MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| CORUM:740 | 8.10772781726e-08 | 0.272727272727 | CASC3 MAGOH RBM8A | Exon junction complex (EIF4A3, MLN51, MAGOH, Y14) |
| REAC:R-HSA-72187 | 1.09583582513e-05 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 2.05703737594e-05 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 2.8070557088e-05 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| CORUM:763 | 3.35524866385e-05 | 0.181818181818 | RBM8A MAGOH | Y14-Magoh complex |
| CORUM:773 | 3.35524866385e-05 | 0.181818181818 | RBM8A MAGOH | Y14-Magoh complex |
| REAC:R-HSA-72202 | 4.64871592246e-05 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Transport of Mature Transcript to Cytoplasm |
| CORUM:1293 | 0.000100616904936 | 0.181818181818 | RBM8A MAGOH | IPO13-RBM8A-MAGOH complex |
| REAC:R-HSA-975957 | 0.000218195219177 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.000218195219177 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Nonsense-Mediated Decay (NMD) |
| CORUM:6742 | 0.00050247669008 | 0.181818181818 | RBM8A MAGOH | SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex |
| GO:0000184 | 0.000512260820572 | 0.454545454545 | MAGOHB PYM1 MAGOH RBM8A CASC3 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| CORUM:785 | 0.000703183938536 | 0.181818181818 | RBM8A MAGOH | Exon junction complex |
| REAC:R-HSA-9010553 | 0.00106271426918 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-72163 | 0.00133689701752 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00159144367827 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA Splicing |
| REAC:R-HSA-376176 | 0.00272025322917 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Signaling by ROBO receptors |
| GO:0071012 | 0.00328477723547 | 0.272727272727 | MAGOHB RBM8A CASC3 | catalytic step 1 spliceosome |
| GO:0071006 | 0.00328477723547 | 0.272727272727 | MAGOHB RBM8A CASC3 | U2-type catalytic step 1 spliceosome |
| REAC:R-HSA-72203 | 0.00400768770777 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | Processing of Capped Intron-Containing Pre-mRNA |
| KEGG:03040 | 0.0045884068153 | 0.272727272727 | MAGOHB MAGOH RBM8A | Spliceosome |
| GO:0000956 | 0.00833349469257 | 0.454545454545 | MAGOHB PYM1 MAGOH RBM8A CASC3 | nuclear-transcribed mRNA catabolic process |
| GO:0031124 | 0.0227301816191 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA 3'-end processing |
| GO:0071427 | 0.039963598761 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0006406 | 0.039963598761 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA export from nucleus |
| HPA:006020_03 | 0.045790560885 | 0.363636363636 | MAGOHB PYM1 SAP18 RBM8A | caudate; neuronal cells[Uncertain,High] |
| GO:0051028 | 0.0480056338961 | 0.363636363636 | MAGOHB MAGOH RBM8A CASC3 | mRNA transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAGOH | RBM8A | 1.0 | 0.949 | hein_WMM bioplex (MAGOH) bioplex_WMM youn_WMM hein (MAGOH,RBM8A) gupta_WMM treiber_WMM |
| MAGOH | PYM1 | 1.0 | 0.949 | hein_WMM bioplex (MAGOH,PYM1) bioplex_WMM youn_WMM hein (MAGOH) |
| RBM8A | PYM1 | 0.384 | 0.55 | hein_WMM bioplex (PYM1) bioplex_WMM youn_WMM hein (RBM8A) gupta_WMM |
| MAGOHB | RBM8A | 0.344 | 0.534 | hein_WMM hein (MAGOHB,RBM8A) gupta_WMM |
| CCDC9 | RBM8A | 0.341 | 0.529 | hein_WMM bioplex_WMM youn_WMM hein (RBM8A) |
| SAP18 | CCDC9 | 0.278 | 0.486 | hein_WMM bioplex_WMM youn_WMM hein (CCDC9) |
| MAGOHB | MAGOH | 0.254 | 0.478 | hein_WMM hein (MAGOH) gupta_WMM |
| SDE2 | RBM8A | 0.159 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (RBM8A) gupta_WMM |
| MAGOHB | FAF1 | 0.114 | 0.385 | fraction |
| CCDC9 | NKTR | 0.103 | 0.366 | hein_WMM bioplex_WMM hein (CCDC9) |
| MAGOH | FAF1 | 0.102 | 0.366 | bioplex_WMM fraction |
| MAGOHB | CCDC9 | 0.098 | 0.358 | hein_WMM hein (CCDC9) |
| FAF1 | BHLHA15 | 0.084 | 0.347 | bioplex (BHLHA15) bioplex_WMM |
| CASC3 | MAGOH | 0.053 | 0.3 | hein_WMM bioplex (MAGOH) bioplex_WMM youn_WMM |
| CASC3 | RBM8A | 0.052 | 0.301 | hein_WMM bioplex_WMM youn_WMM hein (RBM8A) |
| CCDC9 | MAGOH | 0.014 | 0.138 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CASC3 | PYM1 | 0.013 | 0.152 | hein_WMM bioplex (PYM1) bioplex_WMM youn_WMM |
| NKTR | RBM8A | 0.01 | 0.101 | bioplex_WMM WMM_only |
| CASC3 | CCDC9 | 0.009 | 0.1 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CASC3 | NKTR | 0.008 | 0.09 | bioplex_WMM WMM_only |
| SAP18 | RBM8A | 0.008 | 0.084 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SAP18 | NKTR | 0.008 | 0.039 | hein_WMM bioplex_WMM WMM_only |
| SAP18 | MAGOH | 0.008 | 0.023 | bioplex (MAGOH) bioplex_WMM youn_WMM |
| NKTR | MAGOH | 0.008 | 0.023 | bioplex_WMM WMM_only |
| MAGOHB | NKTR | 0.007 | 0.01 | hein_WMM WMM_only |
| FAF1 | PYM1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| MAGOHB | SDE2 | 0.007 | 0.005 | hein_WMM WMM_only |
| SDE2 | MAGOH | 0.007 | 0.006 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SDE2 | PYM1 | 0.007 | 0.002 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SDE2 | FAF1 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| SAP18 | FAF1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| NKTR | FAF1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MAGOHB | SAP18 | 0.007 | 0.005 | hein_WMM WMM_only |
| CCDC9 | PYM1 | 0.007 | 0.005 | hein_WMM youn_WMM WMM_only |
| MAGOHB | CASC3 | 0.007 | 0.004 | hein_WMM WMM_only |
| RBM8A | FAF1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CASC3 | SAP18 | 0.007 | 0.005 | bioplex_WMM youn_WMM WMM_only |
| SAP18 | SDE2 | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| SDE2 | NKTR | 0.006 | 0.005 | bioplex_WMM WMM_only |
| CASC3 | SDE2 | 0.006 | 0.002 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SDE2 | CCDC9 | 0.006 | 0.006 | hein_WMM bioplex_WMM WMM_only |
| SAP18 | PYM1 | 0.005 | 0.009 | bioplex (PYM1) bioplex_WMM youn_WMM gupta_WMM |
| MAGOHB | PYM1 | 0.004 | 0.012 | hein_WMM hein (MAGOHB) |
Images
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Complex HuMAP2_00752 has an average edge precision of 0.19 which is ranked 6313 out of all 6965 complexes.
Related Complexes