hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00757
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HLA-DOA | HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA) | UniProt NCBI |
| HLA-DRA | HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA) | UniProt NCBI |
| HLA-DRB1 | HLA class II histocompatibility antigen, DRB1-3 chain (Clone P2-beta-3) (MHC class II antigen DRB1*3) | UniProt NCBI |
| HLA-DRB5 | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05310 | 1.29206121235e-11 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Asthma |
| KEGG:05330 | 1.08153655327e-10 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Allograft rejection |
| KEGG:05332 | 2.28595445261e-10 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Graft-versus-host disease |
| KEGG:04672 | 2.70158253491e-10 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Intestinal immune network for IgA production |
| KEGG:04940 | 4.29199242719e-10 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Type I diabetes mellitus |
| KEGG:05320 | 9.46186364733e-10 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Autoimmune thyroid disease |
| KEGG:05321 | 2.45312729563e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Inflammatory bowel disease (IBD) |
| KEGG:05416 | 2.94888124387e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Viral myocarditis |
| GO:0042613 | 5.12306788392e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | MHC class II protein complex |
| KEGG:04640 | 5.29157796511e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Hematopoietic cell lineage |
| KEGG:04612 | 5.71490420232e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Antigen processing and presentation |
| WP:WP2328 | 6.42876075454e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Allograft Rejection |
| KEGG:05323 | 6.6372190585e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Rheumatoid arthritis |
| KEGG:05140 | 7.13814125159e-09 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Leishmaniasis |
| KEGG:05150 | 1.30239770204e-08 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Staphylococcus aureus infection |
| KEGG:04658 | 1.75582083365e-08 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Th1 and Th2 cell differentiation |
| KEGG:04659 | 3.83743083606e-08 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Th17 cell differentiation |
| GO:0042611 | 4.43999216606e-08 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | MHC protein complex |
| KEGG:05145 | 5.5106880547e-08 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Toxoplasmosis |
| KEGG:04514 | 7.37816646912e-08 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Cell adhesion molecules (CAMs) |
| WP:WP4217 | 1.16277958104e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Ebola Virus Pathway on Host |
| KEGG:05322 | 1.16353093851e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Systemic lupus erythematosus |
| KEGG:04145 | 2.39127731928e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Phagosome |
| REAC:R-HSA-202430 | 2.96966986958e-07 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Translocation of ZAP-70 to Immunological synapse |
| KEGG:05164 | 3.46789319748e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Influenza A |
| KEGG:05152 | 3.66119097608e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Tuberculosis |
| REAC:R-HSA-202427 | 6.14088879325e-07 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Phosphorylation of CD3 and TCR zeta chains |
| REAC:R-HSA-2132295 | 6.49361324137e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | MHC class II antigen presentation |
| KEGG:05169 | 8.17032558425e-07 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Epstein-Barr virus infection |
| REAC:R-HSA-389948 | 9.1766670065e-07 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | PD-1 signaling |
| KEGG:05166 | 1.09982717057e-06 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-202433 | 3.10262114446e-06 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Generation of second messenger molecules |
| GO:0032395 | 1.27120391093e-05 | 0.75 | HLA-DRA HLA-DOA HLA-DRB1 | MHC class II receptor activity |
| KEGG:05168 | 1.52906522211e-05 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Herpes simplex virus 1 infection |
| REAC:R-HSA-388841 | 3.34108196159e-05 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Costimulation by the CD28 family |
| GO:0019886 | 5.95648368816e-05 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 6.2335294411e-05 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 6.52012849586e-05 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| WP:WP530 | 7.55497829866e-05 | 0.5 | HLA-DRA HLA-DRB1 | Cytokines and Inflammatory Response |
| REAC:R-HSA-877300 | 9.08592662777e-05 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Interferon gamma signaling |
| GO:0023026 | 0.000132158586819 | 0.75 | HLA-DRA HLA-DOA HLA-DRB1 | MHC class II protein complex binding |
| REAC:R-HSA-202424 | 0.000152699585722 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Downstream TCR signaling |
| GO:0023023 | 0.000165189908538 | 0.75 | HLA-DRA HLA-DOA HLA-DRB1 | MHC protein complex binding |
| REAC:R-HSA-202403 | 0.00026664242496 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | TCR signaling |
| GO:0042605 | 0.000351729129078 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | peptide antigen binding |
| GO:0098553 | 0.00064271072446 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | lumenal side of endoplasmic reticulum membrane |
| GO:0071556 | 0.00064271072446 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | integral component of lumenal side of endoplasmic reticulum membrane |
| REAC:R-HSA-1280218 | 0.000660113802024 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Adaptive Immune System |
| GO:0002478 | 0.000691429733885 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation of exogenous peptide antigen |
| GO:0019884 | 0.000726323315176 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation of exogenous antigen |
| GO:0048002 | 0.000879263724448 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation of peptide antigen |
| GO:0098576 | 0.00106129291317 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | lumenal side of membrane |
| REAC:R-HSA-913531 | 0.00115530951203 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Interferon Signaling |
| GO:0030669 | 0.00132566605022 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | clathrin-coated endocytic vesicle membrane |
| GO:0019882 | 0.0014249330287 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | antigen processing and presentation |
| GO:0003823 | 0.00217043933003 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | antigen binding |
| GO:0045334 | 0.00416219722544 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | clathrin-coated endocytic vesicle |
| GO:0005765 | 0.00482615258054 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | lysosomal membrane |
| GO:0098852 | 0.00482615258054 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | lytic vacuole membrane |
| GO:0012507 | 0.00514395792508 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | ER to Golgi transport vesicle membrane |
| GO:0005774 | 0.00806983640441 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | vacuolar membrane |
| GO:0031902 | 0.00950554068334 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | late endosome membrane |
| GO:0060333 | 0.0215903857674 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | interferon-gamma-mediated signaling pathway |
| GO:0030134 | 0.0225145500348 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | COPII-coated ER to Golgi transport vesicle |
| GO:0098797 | 0.0251226492241 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | plasma membrane protein complex |
| GO:0030665 | 0.0254442868917 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | clathrin-coated vesicle membrane |
| GO:0032588 | 0.0320435644688 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | trans-Golgi network membrane |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | Immune System |
| GO:0030660 | 0.037022076332 | 0.75 | HLA-DRA HLA-DRB5 HLA-DRB1 | Golgi-associated vesicle membrane |
| GO:0044437 | 0.0375813449419 | 1.0 | HLA-DRA HLA-DRB5 HLA-DOA HLA-DRB1 | vacuolar part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HLA-DRB1 | 100294276 | 0.97 | 0.881 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRB1 | HLA-DRB5 | 0.954 | 0.861 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRA | HLA-DRB5 | 0.058 | 0.325 | bioplex (HLA-DRA) bioplex_WMM |
| HLA-DRB1 | HLA-DOA | 0.028 | 0.229 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRB5 | 100294276 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| HLA-DOA | 100294276 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| HLA-DRB5 | HLA-DOA | 0.008 | 0.026 | bioplex_WMM WMM_only |
| HLA-DRA | HLA-DRB1 | 0.006 | 0.007 | bioplex (HLA-DRA) bioplex_WMM |
| HLA-DRA | 100294276 | 0.003 | 0.012 | bioplex (HLA-DRA) bioplex_WMM |
Images
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Complex HuMAP2_00757 has an average edge precision of 0.281 which is ranked 4867 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HLA-DOA | HuMAP2_00757 HuMAP2_04434 HuMAP2_06394 |
| HLA-DRA | HuMAP2_00757 HuMAP2_03879 HuMAP2_06394 |
| HLA-DRB1 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |
| HLA-DRB5 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |