hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00758
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0090110 | 9.91350374775e-15 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | COPII-coated vesicle cargo loading |
| GO:0030127 | 1.65225062463e-14 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | COPII vesicle coat |
| WP:WP1982 | 2.47886751564e-13 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| GO:0035459 | 3.33246241367e-13 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | vesicle cargo loading |
| REAC:R-HSA-983170 | 8.55245760774e-12 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 1.29938364124e-11 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Cargo concentration in the ER |
| GO:0012507 | 2.68884724727e-11 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | ER to Golgi transport vesicle membrane |
| GO:0030120 | 3.54468765159e-11 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | vesicle coat |
| KEGG:04141 | 5.77201272041e-11 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | Protein processing in endoplasmic reticulum |
| GO:0051668 | 1.48743735386e-10 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | localization within membrane |
| GO:0090114 | 2.99942969392e-10 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | COPII-coated vesicle budding |
| REAC:R-HSA-1655829 | 3.40583879761e-10 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0030117 | 5.61964776518e-10 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | membrane coat |
| GO:0048194 | 5.61964776518e-10 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | Golgi vesicle budding |
| GO:0030134 | 5.61964776518e-10 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | COPII-coated ER to Golgi transport vesicle |
| GO:0048475 | 5.61964776518e-10 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | coated membrane |
| REAC:R-HSA-204005 | 9.55716061402e-10 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | COPII-mediated vesicle transport |
| GO:0030660 | 1.55207596332e-09 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | Golgi-associated vesicle membrane |
| GO:0006900 | 2.35398129191e-09 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | vesicle budding from membrane |
| GO:0030658 | 5.63153283143e-09 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | transport vesicle membrane |
| GO:0030662 | 2.06313639552e-08 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | coated vesicle membrane |
| REAC:R-HSA-2132295 | 2.56866165763e-08 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | MHC class II antigen presentation |
| GO:0005798 | 2.59426113538e-08 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | Golgi-associated vesicle |
| REAC:R-HSA-8957322 | 3.90905948705e-08 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Metabolism of steroids |
| REAC:R-HSA-199977 | 7.69127566392e-08 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | ER to Golgi Anterograde Transport |
| GO:0006888 | 1.58520683947e-07 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-948021 | 1.7280486461e-07 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Transport to the Golgi and subsequent modification |
| GO:0048208 | 2.67615521812e-07 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | COPII vesicle coating |
| GO:0048207 | 2.67615521812e-07 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | vesicle targeting, rough ER to cis-Golgi |
| GO:0030135 | 3.55443487864e-07 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | coated vesicle |
| GO:0006901 | 3.73519189534e-07 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | vesicle coating |
| GO:0048199 | 5.10555594437e-07 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | vesicle targeting, to, from or within Golgi |
| GO:0030133 | 8.43728730253e-07 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | transport vesicle |
| GO:0006903 | 1.51069859482e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | vesicle targeting |
| GO:0016050 | 1.60573024546e-06 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | vesicle organization |
| GO:0019886 | 2.03057391679e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 2.14989853687e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 2.27476470409e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| GO:0002474 | 2.27476470409e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of peptide antigen via MHC class I |
| REAC:R-HSA-446203 | 2.39939306913e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Asparagine N-linked glycosylation |
| GO:0048193 | 5.76124540195e-06 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | Golgi vesicle transport |
| REAC:R-HSA-983169 | 6.62586152292e-06 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Class I MHC mediated antigen processing & presentation |
| CORUM:7139 | 8.39001385941e-06 | 0.333333333333 | SEC23A SEC24B | SEC23-SEC24 adaptor complex |
| KEGG:05130 | 1.31440902986e-05 | 0.666666666667 | SEC24D SEC24B SEC24C SEC24A | Pathogenic Escherichia coli infection |
| GO:0051650 | 3.75106719902e-05 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | establishment of vesicle localization |
| GO:0002478 | 4.39080435103e-05 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of exogenous peptide antigen |
| GO:0019884 | 4.66987999087e-05 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of exogenous antigen |
| GO:0051648 | 4.81463539559e-05 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | vesicle localization |
| CORUM:7140 | 5.0322056017e-05 | 0.333333333333 | SEC23A SEC24B | SEC23-SEC24-SCAP-SREBP1c complex |
| GO:0048002 | 5.93143067578e-05 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation of peptide antigen |
| GO:0030659 | 6.30724445667e-05 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | cytoplasmic vesicle membrane |
| GO:0012506 | 7.47001039133e-05 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | vesicle membrane |
| CORUM:7141 | 8.38550741504e-05 | 0.333333333333 | SEC23A SEC24B | Coat protein complex II (SAR1B, PREB, SEC23A , SEC24B, SEC23IP) |
| REAC:R-HSA-199991 | 8.45689503243e-05 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Membrane Trafficking |
| GO:0019882 | 0.000108502874865 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | antigen processing and presentation |
| REAC:R-HSA-5653656 | 0.000110463892332 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Vesicle-mediated transport |
| REAC:R-HSA-556833 | 0.000135849226303 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Metabolism of lipids |
| REAC:R-HSA-1280218 | 0.00014564509793 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Adaptive Immune System |
| GO:0061024 | 0.000246865616926 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | membrane organization |
| GO:0008270 | 0.000855387025665 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | zinc ion binding |
| GO:0051656 | 0.00117107221448 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | establishment of organelle localization |
| GO:0098796 | 0.00190067692149 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | membrane protein complex |
| HP:0002868 | 0.00210158306671 | 0.333333333333 | SEC23A SEC24D | Narrow iliac wings |
| GO:0044432 | 0.00269950977469 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | endoplasmic reticulum part |
| REAC:R-HSA-597592 | 0.00391856777133 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Post-translational protein modification |
| GO:0046914 | 0.0046371909663 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | transition metal ion binding |
| GO:0044433 | 0.00578472598372 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | cytoplasmic vesicle part |
| GO:0098805 | 0.00796870962922 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | whole membrane |
| GO:0051640 | 0.0109160303478 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | organelle localization |
| HP:0005692 | 0.015007845 | 0.5 | SEC23A SEC24C SEC24D | Joint hyperflexibility |
| REAC:R-HSA-168256 | 0.0201098402149 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Immune System |
| GO:0005783 | 0.023225190532 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | endoplasmic reticulum |
| REAC:R-HSA-392499 | 0.0232605972232 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Metabolism of proteins |
| GO:0098588 | 0.0263661961424 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | bounding membrane of organelle |
| REAC:R-HSA-1430728 | 0.0278608311428 | 0.833333333333 | SEC24D SEC23A SEC24C SEC24A SEC24B | Metabolism |
| HP:0000765 | 0.0289490814787 | 0.666666666667 | SEC24D SEC23B SEC24C SEC23A | Abnormality of the thorax |
| HP:0000262 | 0.030358517586 | 0.333333333333 | SEC24D SEC24C | Turricephaly |
| HP:0011329 | 0.0380225871731 | 0.5 | SEC23A SEC24C SEC24D | Abnormality of cranial sutures |
| GO:0046907 | 0.038148924612 | 1.0 | SEC24A SEC24B SEC23B SEC23A SEC24C SEC24D | intracellular transport |
| HP:0001382 | 0.0410803928175 | 0.5 | SEC23A SEC24C SEC24D | Joint hypermobility |
| HP:0011061 | 0.0459638888097 | 0.5 | SEC23A SEC24C SEC24D | Abnormality of dental structure |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SEC24C | SEC23A | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24C | SEC23B | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) Malo gupta_WMM fraction |
| SEC23B | SEC24B | 0.966 | 0.875 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| SEC24A | SEC24D | 0.803 | 0.766 | bioplex_WMM Malo fraction |
| SEC23A | SEC24A | 0.776 | 0.752 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23B | SEC24D | 0.679 | 0.708 | bioplex_WMM Malo fraction |
| SEC23A | SEC24D | 0.551 | 0.644 | bioplex_WMM Malo fraction |
| SEC24C | SEC24B | 0.084 | 0.347 | hein_WMM bioplex_WMM youn_WMM hein (SEC24C) gupta_WMM fraction |
| SEC23B | SEC24A | 0.072 | 0.354 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24C | SEC24D | 0.039 | 0.264 | bioplex_WMM Malo fraction |
| SEC24C | SEC24A | 0.023 | 0.207 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24B | SEC24A | 0.008 | 0.088 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SEC23A | SEC24B | 0.007 | 0.001 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC24B | SEC24D | 0.0 | 0.014 | bioplex_WMM fraction |
Images
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Complex HuMAP2_00758 has an average edge precision of 0.524 which is ranked 2374 out of all 6965 complexes.
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