hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00762
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TGS1 | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) | UniProt NCBI |
| NHP2 | H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2) | UniProt NCBI |
| FBL | rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) | UniProt NCBI |
| RRP9 | U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K) | UniProt NCBI |
| NAP1L2 | Nucleosome assembly protein 1-like 2 (Brain-specific protein, X-linked) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6790901 | 9.25148000407e-05 | 0.6 | FBL NHP2 RRP9 | rRNA modification in the nucleus and cytosol |
| GO:0005732 | 0.000878614215261 | 0.6 | FBL NHP2 RRP9 | small nucleolar ribonucleoprotein complex |
| REAC:R-HSA-8953854 | 0.00262978456954 | 0.8 | FBL TGS1 NHP2 RRP9 | Metabolism of RNA |
| REAC:R-HSA-8868773 | 0.00304975168622 | 0.6 | FBL NHP2 RRP9 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.00355347569673 | 0.6 | FBL NHP2 RRP9 | rRNA processing |
| KEGG:03008 | 0.0124368761918 | 0.4 | FBL NHP2 | Ribosome biogenesis in eukaryotes |
| GO:0031428 | 0.0450641792523 | 0.4 | FBL RRP9 | box C/D snoRNP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FBL | TGS1 | 0.965 | 0.874 | bioplex (FBL) bioplex_WMM |
| RRP9 | FBL | 0.964 | 0.873 | hein_WMM bioplex (FBL) bioplex_WMM hein (FBL) gupta_WMM treiber_WMM |
| NAP1L2 | FBL | 0.948 | 0.856 | bioplex (FBL) bioplex_WMM |
| NHP2 | FBL | 0.798 | 0.764 | bioplex_WMM fraction treiber_WMM |
| RRP9 | NHP2 | 0.019 | 0.185 | bioplex_WMM youn_WMM fraction treiber_WMM |
| NAP1L2 | TGS1 | 0.008 | 0.094 | bioplex_WMM WMM_only |
| RRP9 | NAP1L2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| RRP9 | TGS1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00762 has an average edge precision of 0.457 which is ranked 2820 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TGS1 | HuMAP2_00762 HuMAP2_03068 HuMAP2_05007 HuMAP2_05049 HuMAP2_06004 |
| NHP2 | HuMAP2_00762 HuMAP2_02643 HuMAP2_02924 HuMAP2_04574 |
| FBL | HuMAP2_00762 HuMAP2_02929 HuMAP2_03778 HuMAP2_04502 HuMAP2_06797 |
| RRP9 | HuMAP2_00041 HuMAP2_00762 HuMAP2_01863 HuMAP2_02614 HuMAP2_02899 |
| NAP1L2 | HuMAP2_00762 HuMAP2_02929 |