hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00777
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | UniProt NCBI |
| XPA | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:531 | 5.02777038712e-06 | 1.0 | ERCC4 XPA | XPA-ERCC1-ERCC4 complex |
| HP:0010649 | 9.35041149526e-05 | 1.0 | ERCC4 XPA | Flat nasal alae |
| KEGG:03420 | 0.000138019076752 | 1.0 | ERCC4 XPA | Nucleotide excision repair |
| HP:0009755 | 0.000220402556674 | 1.0 | ERCC4 XPA | Ankyloblepharon |
| HP:0003079 | 0.000220402556674 | 1.0 | ERCC4 XPA | Defective DNA repair after ultraviolet radiation damage |
| HP:0001029 | 0.000303888373596 | 1.0 | ERCC4 XPA | Poikiloderma |
| HP:0003254 | 0.000350640431072 | 1.0 | ERCC4 XPA | Abnormality of DNA repair |
| GO:1901255 | 0.000450823411379 | 1.0 | ERCC4 XPA | nucleotide-excision repair involved in interstrand cross-link repair |
| HP:0000621 | 0.000571042987746 | 1.0 | ERCC4 XPA | Entropion |
| HP:0000524 | 0.000571042987746 | 1.0 | ERCC4 XPA | Conjunctival telangiectasia |
| HP:0008054 | 0.000771408948359 | 1.0 | ERCC4 XPA | Abnormal morphology of the conjunctival vasculature |
| HP:0004493 | 0.00108531561999 | 1.0 | ERCC4 XPA | Craniofacial hyperostosis |
| HP:0001059 | 0.00117214086958 | 1.0 | ERCC4 XPA | Pterygium |
| GO:0000110 | 0.00135247023414 | 1.0 | ERCC4 XPA | nucleotide-excision repair factor 1 complex |
| REAC:R-HSA-5696400 | 0.00137425723915 | 1.0 | ERCC4 XPA | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.00151335888652 | 1.0 | ERCC4 XPA | Formation of Incision Complex in GG-NER |
| HP:0100579 | 0.00165635860773 | 1.0 | ERCC4 XPA | Mucosal telangiectasiae |
| HP:0100012 | 0.00210384258643 | 1.0 | ERCC4 XPA | Neoplasm of the eye |
| HP:0012740 | 0.0022240621628 | 1.0 | ERCC4 XPA | Papilloma |
| HP:0004437 | 0.00260475748797 | 1.0 | ERCC4 XPA | Cranial hyperostosis |
| HP:0001480 | 0.00273833479504 | 1.0 | ERCC4 XPA | Freckling |
| HP:0000498 | 0.00287525153479 | 1.0 | ERCC4 XPA | Blepharitis |
| HP:0100774 | 0.00345631282057 | 1.0 | ERCC4 XPA | Hyperostosis |
| HP:0006887 | 0.00345631282057 | 1.0 | ERCC4 XPA | Intellectual disability, progressive |
| REAC:R-HSA-6782135 | 0.00348592080174 | 1.0 | ERCC4 XPA | Dual incision in TC-NER |
| HP:0000995 | 0.00360992672371 | 1.0 | ERCC4 XPA | Melanocytic nevus |
| HP:0000656 | 0.00425777666302 | 1.0 | ERCC4 XPA | Ectropion |
| REAC:R-HSA-6781827 | 0.00503279815751 | 1.0 | ERCC4 XPA | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HP:0002861 | 0.00552008221488 | 1.0 | ERCC4 XPA | Melanoma |
| REAC:R-HSA-5696399 | 0.00584226918984 | 1.0 | ERCC4 XPA | Global Genome Nucleotide Excision Repair (GG-NER) |
| HP:0000491 | 0.00591079583808 | 1.0 | ERCC4 XPA | Keratitis |
| HP:0100585 | 0.00591079583808 | 1.0 | ERCC4 XPA | Telangiectasia of the skin |
| HP:0001034 | 0.00631486719198 | 1.0 | ERCC4 XPA | Hypermelanotic macule |
| HP:0007759 | 0.00694601996791 | 1.0 | ERCC4 XPA | Opacification of the corneal stroma |
| HP:0004334 | 0.00738348564858 | 1.0 | ERCC4 XPA | Dermal atrophy |
| HP:0011492 | 0.00760722763793 | 1.0 | ERCC4 XPA | Abnormality of corneal stroma |
| HP:0000963 | 0.00760722763793 | 1.0 | ERCC4 XPA | Thin skin |
| HP:0000992 | 0.00926692567834 | 1.0 | ERCC4 XPA | Cutaneous photosensitivity |
| REAC:R-HSA-5696398 | 0.0100471611569 | 1.0 | ERCC4 XPA | Nucleotide Excision Repair |
| HP:0011495 | 0.0116412623116 | 1.0 | ERCC4 XPA | Abnormal corneal epithelium morphology |
| HP:0012733 | 0.0145966602306 | 1.0 | ERCC4 XPA | Macule |
| HP:0010783 | 0.0152278130066 | 1.0 | ERCC4 XPA | Erythema |
| HP:0003764 | 0.0165301917506 | 1.0 | ERCC4 XPA | Nevus |
| HP:0008734 | 0.0165301917506 | 1.0 | ERCC4 XPA | Decreased testicular size |
| HP:0001009 | 0.0182333024158 | 1.0 | ERCC4 XPA | Telangiectasia |
| HP:0001053 | 0.0182333024158 | 1.0 | ERCC4 XPA | Hypopigmented skin patches |
| HP:0000502 | 0.0207579135195 | 1.0 | ERCC4 XPA | Abnormal conjunctiva morphology |
| HP:0007400 | 0.0222740159548 | 1.0 | ERCC4 XPA | Irregular hyperpigmentation |
| HP:0003355 | 0.0234461568244 | 1.0 | ERCC4 XPA | Aminoaciduria |
| HP:0000958 | 0.0234461568244 | 1.0 | ERCC4 XPA | Dry skin |
| HP:0010468 | 0.0234461568244 | 1.0 | ERCC4 XPA | Aplasia/Hypoplasia of the testes |
| GO:0000109 | 0.0247952876258 | 1.0 | ERCC4 XPA | nucleotide-excision repair complex |
| HP:0002829 | 0.0254665135939 | 1.0 | ERCC4 XPA | Arthralgia |
| HP:0045058 | 0.0288727349243 | 1.0 | ERCC4 XPA | Abnormality of the testis size |
| HP:0008065 | 0.0348636771466 | 1.0 | ERCC4 XPA | Aplasia/Hypoplasia of the skin |
| HP:0008069 | 0.0383233293999 | 1.0 | ERCC4 XPA | Neoplasm of the skin |
| HP:0100533 | 0.0383233293999 | 1.0 | ERCC4 XPA | Inflammatory abnormality of the eye |
| HP:0001596 | 0.0388309231668 | 1.0 | ERCC4 XPA | Alopecia |
| HP:0001010 | 0.0419466138543 | 1.0 | ERCC4 XPA | Hypopigmentation of the skin |
| HP:0012072 | 0.047406586281 | 1.0 | ERCC4 XPA | Aciduria |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERCC4 | XPA | 0.028 | 0.229 | bioplex (XPA) bioplex_WMM |
Images
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Complex HuMAP2_00777 has an average edge precision of 0.229 which is ranked 5716 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ERCC4 | HuMAP2_00595 HuMAP2_00777 HuMAP2_02823 HuMAP2_03411 HuMAP2_04070 HuMAP2_04705 HuMAP2_05771 |
| XPA | HuMAP2_00777 HuMAP2_02823 HuMAP2_03411 HuMAP2_04705 HuMAP2_04997 HuMAP2_05771 |