hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00794
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATG4C | Cysteine protease ATG4C (EC 3.4.22.-) (AUT-like 3 cysteine endopeptidase) (Autophagin-3) (Autophagy-related cysteine endopeptidase 3) (Autophagy-related protein 4 homolog C) | UniProt NCBI |
| GSTA2 | Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2) | UniProt NCBI |
| GSTA1 | Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed] | UniProt NCBI |
| GSTA5 | Glutathione S-transferase A5 (EC 2.5.1.18) (GST class-alpha member 5) (Glutathione S-transferase A5-5) | UniProt NCBI |
| GSTA4 | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4) | UniProt NCBI |
| GSTA3 | Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156590 | 4.47689166872e-11 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Glutathione conjugation |
| KEGG:00480 | 8.65699266967e-11 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Glutathione metabolism |
| KEGG:00982 | 2.47792149826e-10 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 3.4585110142e-10 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:05204 | 5.09640586206e-10 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Chemical carcinogenesis |
| KEGG:00983 | 6.3437725958e-10 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Drug metabolism - other enzymes |
| KEGG:01524 | 6.3437725958e-10 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Platinum drug resistance |
| GO:0004364 | 1.29312581721e-09 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | glutathione transferase activity |
| WP:WP2884 | 5.17530797793e-09 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | NRF2 pathway |
| REAC:R-HSA-156580 | 9.29023553832e-09 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Phase II - Conjugation of compounds |
| KEGG:05418 | 1.06019966074e-08 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Fluid shear stress and atherosclerosis |
| WP:WP702 | 3.20052600015e-08 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 3.58577450017e-08 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Hepatocellular carcinoma |
| GO:0006749 | 4.17250787048e-08 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | glutathione metabolic process |
| GO:0016765 | 9.34955208324e-08 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| REAC:R-HSA-211859 | 2.88008202077e-07 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Biological oxidations |
| WP:WP2882 | 3.66896638601e-07 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Nuclear Receptors Meta-Pathway |
| GO:1901685 | 2.18611257075e-06 | 0.666666666667 | GSTA1 GSTA3 GSTA4 GSTA2 | glutathione derivative metabolic process |
| GO:1901687 | 2.18611257075e-06 | 0.666666666667 | GSTA1 GSTA3 GSTA4 GSTA2 | glutathione derivative biosynthetic process |
| GO:0006805 | 3.68082360643e-06 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | xenobiotic metabolic process |
| GO:0071466 | 7.83441805577e-06 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | cellular response to xenobiotic stimulus |
| KEGG:05200 | 7.8613903291e-06 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Pathways in cancer |
| GO:0009410 | 1.01218111583e-05 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | response to xenobiotic stimulus |
| GO:0006575 | 2.18545851389e-05 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | cellular modified amino acid metabolic process |
| WP:WP100 | 0.000852627081304 | 0.333333333333 | GSTA1 GSTA5 | Glutathione metabolism |
| GO:0006790 | 0.000884985147402 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | sulfur compound metabolic process |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Metabolic pathways |
| GO:0051186 | 0.00242709225706 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | cofactor metabolic process |
| GO:0044272 | 0.00832729271377 | 0.666666666667 | GSTA1 GSTA3 GSTA4 GSTA2 | sulfur compound biosynthetic process |
| TF:M04091 | 0.0273937790841 | 0.5 | GSTA1 GSTA5 GSTA2 | Factor: POU6F2; motif: GCTAATTANN |
| TF:M04091_0 | 0.0273937790841 | 0.5 | GSTA1 GSTA5 GSTA2 | Factor: POU6F2; motif: GCTAATTANN; match class: 0 |
| REAC:R-HSA-1430728 | 0.0278608311428 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | Metabolism |
| GO:0006518 | 0.0430733890744 | 0.833333333333 | GSTA1 GSTA4 GSTA3 GSTA5 GSTA2 | peptide metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSTA1 | GSTA3 | 1.0 | 0.949 | bioplex (GSTA1) bioplex_WMM |
| GSTA2 | GSTA5 | 1.0 | 0.949 | bioplex (GSTA2) bioplex_WMM |
| GSTA2 | GSTA3 | 1.0 | 0.949 | bioplex (GSTA2) bioplex_WMM |
| GSTA2 | GSTA4 | 0.602 | 0.671 | bioplex (GSTA2) bioplex_WMM |
| GSTA1 | GSTA4 | 0.579 | 0.661 | bioplex (GSTA1) bioplex_WMM |
| ATG4C | GSTA2 | 0.06 | 0.336 | bioplex (GSTA2) bioplex_WMM |
| GSTA4 | GSTA3 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| GSTA5 | GSTA3 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GSTA5 | GSTA4 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ATG4C | GSTA5 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ATG4C | GSTA3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| ATG4C | GSTA4 | 0.008 | 0.086 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00794 has an average edge precision of 0.429 which is ranked 3032 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATG4C | HuMAP2_00794 HuMAP2_01581 HuMAP2_05881 |
| GSTA2 | HuMAP2_00794 HuMAP2_05324 |
| GSTA1 | HuMAP2_00794 HuMAP2_05901 |
| GSTA5 | HuMAP2_00794 HuMAP2_05324 |
| GSTA4 | HuMAP2_00794 |
| GSTA3 | HuMAP2_00794 HuMAP2_05901 |