hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00802
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUZ12 | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | UniProt NCBI |
| EPOP | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | UniProt NCBI |
| EZH1 | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.43) (ENX-2) (Enhancer of zeste homolog 1) | UniProt NCBI |
| MTF2 | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035098 | 4.43999216606e-08 | 1.0 | EZH1 SUZ12 EPOP MTF2 | ESC/E(Z) complex |
| WP:WP2916 | 1.26273546911e-07 | 0.75 | EZH1 SUZ12 MTF2 | Interactome of polycomb repressive complex 2 (PRC2) |
| GO:0031519 | 3.98098967922e-06 | 1.0 | EZH1 SUZ12 EPOP MTF2 | PcG protein complex |
| GO:0035097 | 3.85835319231e-05 | 1.0 | EZH1 SUZ12 EPOP MTF2 | histone methyltransferase complex |
| GO:0034708 | 0.000125895977869 | 1.0 | EZH1 SUZ12 EPOP MTF2 | methyltransferase complex |
| GO:0003682 | 0.014316845247 | 1.0 | EZH1 SUZ12 EPOP MTF2 | chromatin binding |
| REAC:R-HSA-212300 | 0.0255411590024 | 0.5 | MTF2 SUZ12 | PRC2 methylates histones and DNA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUZ12 | EPOP | 0.99 | 0.909 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| SUZ12 | MTF2 | 0.897 | 0.822 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| 26148 | SUZ12 | 0.693 | 0.717 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| SUZ12 | EZH1 | 0.5 | 0.621 | bioplex (SUZ12) bioplex_WMM |
| 26148 | EPOP | 0.009 | 0.107 | hein_WMM bioplex_WMM WMM_only |
| EPOP | MTF2 | 0.009 | 0.091 | hein_WMM bioplex_WMM WMM_only |
| EPOP | EZH1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| 26148 | EZH1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| EZH1 | MTF2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| 26148 | MTF2 | 0.008 | 0.028 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00802 has an average edge precision of 0.353 which is ranked 3887 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUZ12 | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| EPOP | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 |
| EZH1 | HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03308 |
| MTF2 | HuMAP2_00802 HuMAP2_01172 HuMAP2_02229 |