hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00805
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CFAP410 | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | UniProt NCBI |
| NEK1 | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | UniProt NCBI |
| TTC25 | Tetratricopeptide repeat protein 25 (TPR repeat protein 25) | UniProt NCBI |
| ARMC4 | Armadillo repeat-containing protein 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0031815 | 1.101435917e-05 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormal oral physiology |
| HP:0012207 | 3.75977833456e-05 | 0.75 | TTC25 CFAP410 ARMC4 | Reduced sperm motility |
| HP:0012206 | 3.75977833456e-05 | 0.75 | TTC25 CFAP410 ARMC4 | Abnormal sperm motility |
| HP:0002094 | 8.46328877129e-05 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Dyspnea |
| HP:0002087 | 9.35490492274e-05 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the upper respiratory tract |
| HP:0002789 | 0.000420585039486 | 0.75 | TTC25 NEK1 ARMC4 | Tachypnea |
| HP:0000025 | 0.00138633858335 | 0.75 | TTC25 CFAP410 ARMC4 | Functional abnormality of male internal genitalia |
| HP:0002090 | 0.00141618772939 | 0.75 | TTC25 CFAP410 ARMC4 | Pneumonia |
| HP:0000765 | 0.00156743190196 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the thorax |
| HP:0012874 | 0.00226669049436 | 0.75 | TTC25 CFAP410 ARMC4 | Abnormal male reproductive system physiology |
| HP:0002088 | 0.00235344527213 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormal lung morphology |
| HP:0025142 | 0.0026954869199 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Constitutional symptom |
| HP:0012252 | 0.00438590224133 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormal respiratory system morphology |
| HP:0002012 | 0.00662656539009 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the abdominal organs |
| HP:0002795 | 0.00671170230548 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Functional respiratory abnormality |
| HP:0000405 | 0.00862487853069 | 0.75 | TTC25 NEK1 ARMC4 | Conductive hearing impairment |
| HP:0011452 | 0.00892789465924 | 0.75 | TTC25 NEK1 ARMC4 | Functional abnormality of the middle ear |
| HP:0000925 | 0.0102449195425 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the vertebral column |
| HP:0002793 | 0.0127391041765 | 0.75 | TTC25 NEK1 ARMC4 | Abnormal pattern of respiration |
| HP:0030195 | 0.0134847743701 | 0.5 | NEK1 CFAP410 | Fatigable weakness of swallowing muscles |
| HP:0025425 | 0.0142767163782 | 0.5 | NEK1 CFAP410 | Laryngospasm |
| HP:0000078 | 0.0143510578436 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the genital system |
| HP:0002813 | 0.0148102559841 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of limb bone morphology |
| HP:0040068 | 0.0148102559841 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of limb bone |
| HP:0031456 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Ectopic pregnancy |
| HP:0012262 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Abnormal ciliary motility |
| HP:0012261 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Abnormal respiratory motile cilium physiology |
| HP:0040262 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Glue ear |
| HP:0031603 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Impaired nasal mucociliary clearance |
| HP:0031602 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Abnormal mucociliary clearance |
| HP:0012263 | 0.0150911756538 | 0.5 | TTC25 ARMC4 | Immotile cilia |
| HP:0100812 | 0.01857406376 | 0.5 | TTC25 ARMC4 | Halitosis |
| HP:0000766 | 0.0193139149318 | 0.75 | TTC25 NEK1 ARMC4 | Abnormality of the sternum |
| HP:0011844 | 0.0199031996946 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormal appendicular skeleton morphology |
| HP:0011109 | 0.0204504532642 | 0.5 | TTC25 ARMC4 | Chronic sinusitis |
| HP:0007354 | 0.0204504532642 | 0.5 | NEK1 CFAP410 | Amyotrophic lateral sclerosis |
| HP:0100582 | 0.0204504532642 | 0.5 | TTC25 ARMC4 | Nasal polyposis |
| HP:0025424 | 0.0204504532642 | 0.5 | NEK1 CFAP410 | Abnormal larynx physiology |
| HP:0002597 | 0.0204895073105 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the vasculature |
| HP:0004469 | 0.0214223630957 | 0.5 | TTC25 ARMC4 | Chronic bronchitis |
| HP:0000433 | 0.023433582519 | 0.5 | TTC25 ARMC4 | Abnormality of the nasal mucosa |
| HP:0002205 | 0.0246872802511 | 0.75 | TTC25 CFAP410 ARMC4 | Recurrent respiratory infections |
| HP:0000217 | 0.025534627766 | 0.5 | NEK1 CFAP410 | Xerostomia |
| HP:0002086 | 0.0266071423153 | 1.0 | TTC25 NEK1 ARMC4 CFAP410 | Abnormality of the respiratory system |
| HP:0030192 | 0.0266188198793 | 0.5 | NEK1 CFAP410 | Fatigable weakness of bulbar muscles |
| HP:0000370 | 0.0278183273244 | 0.75 | TTC25 NEK1 ARMC4 | Abnormality of the middle ear |
| HP:0030196 | 0.0288545127028 | 0.5 | NEK1 CFAP410 | Fatigable weakness of respiratory muscles |
| HP:0025408 | 0.0289176088458 | 0.75 | TTC25 CFAP410 ARMC4 | Abnormal spleen morphology |
| HP:0007373 | 0.0311799098191 | 0.5 | NEK1 CFAP410 | Motor neuron atrophy |
| HP:0011947 | 0.0328696021072 | 0.75 | TTC25 CFAP410 ARMC4 | Respiratory tract infection |
| HP:0001743 | 0.0331125866707 | 0.75 | TTC25 CFAP410 ARMC4 | Abnormality of the spleen |
| HP:0100750 | 0.0348360947433 | 0.5 | TTC25 ARMC4 | Atelectasis |
| HP:0005268 | 0.0360996225593 | 0.5 | TTC25 ARMC4 | Spontaneous abortion |
| HP:0100759 | 0.0386938410225 | 0.5 | TTC25 ARMC4 | Clubbing of fingers |
| HP:0002093 | 0.0393064686239 | 0.75 | NEK1 ARMC4 CFAP410 | Respiratory insufficiency |
| HP:0000080 | 0.0406864321028 | 0.75 | TTC25 CFAP410 ARMC4 | Abnormality of reproductive system physiology |
| HP:0012384 | 0.0427529847392 | 0.5 | TTC25 ARMC4 | Rhinitis |
| HP:0001746 | 0.0470133620262 | 0.5 | TTC25 ARMC4 | Asplenia |
| HP:0002450 | 0.0470133620262 | 0.5 | NEK1 CFAP410 | Abnormal motor neuron morphology |
| HP:0010451 | 0.048478178044 | 0.5 | TTC25 ARMC4 | Aplasia/Hypoplasia of the spleen |
| HP:0002180 | 0.049965329079 | 0.5 | NEK1 CFAP410 | Neurodegeneration |
| HP:0012757 | 0.049965329079 | 0.5 | NEK1 CFAP410 | Abnormal neuron morphology |
| HP:0006536 | 0.049965329079 | 0.5 | TTC25 ARMC4 | Obstructive lung disease |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NEK1 | CFAP410 | 0.998 | 0.943 | hein_WMM bioplex_WMM boldt (CFAP410,NEK1) hein (NEK1) gupta_WMM boldt_WMM |
| TTC25 | ARMC4 | 0.124 | 0.397 | bioplex (TTC25) bioplex_WMM |
| NEK1 | TTC25 | 0.102 | 0.366 | bioplex (TTC25) bioplex_WMM |
| TTC25 | CFAP410 | 0.068 | 0.348 | bioplex (TTC25) bioplex_WMM |
| NEK1 | ARMC4 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CFAP410 | ARMC4 | 0.008 | 0.044 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00805 has an average edge precision of 0.361 which is ranked 3750 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CFAP410 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 |
| NEK1 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 HuMAP2_06217 |
| TTC25 | HuMAP2_00805 HuMAP2_01908 HuMAP2_06049 |
| ARMC4 | HuMAP2_00805 HuMAP2_01908 HuMAP2_06049 |