hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00817
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MFN2 | Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2) | UniProt NCBI |
| TMC1 | Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1) | UniProt NCBI |
| MFN1 | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04137 | 0.000844586654193 | 0.666666666667 | MFN2 MFN1 | Mitophagy - animal |
| REAC:R-HSA-5205685 | 0.00114404160216 | 0.666666666667 | MFN2 MFN1 | Pink/Parkin Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.00184610965854 | 0.666666666667 | MFN2 MFN1 | Mitophagy |
| HP:0000360 | 0.00495195349433 | 0.666666666667 | MFN2 TMC1 | Tinnitus |
| KEGG:04621 | 0.00551574183542 | 0.666666666667 | MFN2 MFN1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-1632852 | 0.0249521708712 | 0.666666666667 | MFN2 MFN1 | Macroautophagy |
| REAC:R-HSA-9612973 | 0.0350118981581 | 0.666666666667 | MFN2 MFN1 | Autophagy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TMC1 | MFN1 | 0.325 | 0.514 | bioplex (MFN1) bioplex_WMM |
| MFN1 | MFN2 | 0.113 | 0.383 | bioplex (MFN1) bioplex_WMM |
| TMC1 | MFN2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00817 has an average edge precision of 0.327 which is ranked 4252 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MFN2 | HuMAP2_00817 HuMAP2_03643 |
| TMC1 | HuMAP2_00817 HuMAP2_04185 |
| MFN1 | HuMAP2_00817 HuMAP2_04185 |