hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00819
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK12 | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | UniProt NCBI |
| MAPK13 | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | UniProt NCBI |
| TANC1 | Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1) | UniProt NCBI |
| MYLK3 | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04611 | 5.93639809967e-05 | 0.75 | MAPK12 MYLK3 MAPK13 | Platelet activation |
| WP:WP3612 | 0.000387405527127 | 0.5 | MAPK12 MAPK13 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| WP:WP3869 | 0.000424263272643 | 0.5 | MAPK12 MAPK13 | Cannabinoid receptor signaling |
| REAC:R-HSA-376172 | 0.000552609179875 | 0.5 | MAPK12 MAPK13 | DSCAM interactions |
| WP:WP2643 | 0.000633595541779 | 0.5 | MAPK12 MAPK13 | Nanoparticle-mediated activation of receptor signaling |
| REAC:R-HSA-171007 | 0.000663071622452 | 0.5 | MAPK12 MAPK13 | p38MAPK events |
| WP:WP2371 | 0.00105523555839 | 0.5 | MAPK12 MAPK13 | Parkinsons Disease Pathway |
| REAC:R-HSA-167044 | 0.00136571756437 | 0.5 | MAPK12 MAPK13 | Signalling to RAS |
| WP:WP3611 | 0.00180886504004 | 0.5 | MAPK12 MAPK13 | Photodynamic therapy-induced AP-1 survival signaling. |
| WP:WP3865 | 0.0023930258657 | 0.5 | MAPK12 MAPK13 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:05014 | 0.00254347186047 | 0.5 | MAPK12 MAPK13 | Amyotrophic lateral sclerosis (ALS) |
| WP:WP4538 | 0.00257484178538 | 0.5 | MAPK12 MAPK13 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:04370 | 0.00296133374321 | 0.5 | MAPK12 MAPK13 | VEGF signaling pathway |
| KEGG:04664 | 0.00296133374321 | 0.5 | MAPK12 MAPK13 | Fc epsilon RI signaling pathway |
| KEGG:05140 | 0.00318211487745 | 0.5 | MAPK12 MAPK13 | Leishmaniasis |
| WP:WP4341 | 0.00326331699224 | 0.5 | MAPK12 MAPK13 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| WP:WP3303 | 0.0034749006715 | 0.5 | MAPK12 MAPK13 | RAC1/PAK1/p38/MMP2 Pathway |
| KEGG:05133 | 0.00352808727693 | 0.5 | MAPK12 MAPK13 | Pertussis |
| KEGG:05120 | 0.00364735612249 | 0.5 | MAPK12 MAPK13 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04917 | 0.00376859643257 | 0.5 | MAPK12 MAPK13 | Prolactin signaling pathway |
| KEGG:04622 | 0.00401698930658 | 0.5 | MAPK12 MAPK13 | RIG-I-like receptor signaling pathway |
| KEGG:05131 | 0.00401698930658 | 0.5 | MAPK12 MAPK13 | Shigellosis |
| REAC:R-HSA-187687 | 0.00407268683926 | 0.5 | MAPK12 MAPK13 | Signalling to ERKs |
| KEGG:05132 | 0.00440435122993 | 0.5 | MAPK12 MAPK13 | Salmonella infection |
| KEGG:04657 | 0.00480942745524 | 0.5 | MAPK12 MAPK13 | IL-17 signaling pathway |
| KEGG:04658 | 0.00494838688052 | 0.5 | MAPK12 MAPK13 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-168638 | 0.00596538345738 | 0.5 | MAPK12 MAPK13 | NOD1/2 Signaling Pathway |
| KEGG:05235 | 0.00628743288644 | 0.5 | MAPK12 MAPK13 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP75 | 0.0063819591539 | 0.5 | MAPK12 MAPK13 | Toll-like Receptor Signaling Pathway |
| KEGG:04750 | 0.00644602944709 | 0.5 | MAPK12 MAPK13 | Inflammatory mediator regulation of TRP channels |
| KEGG:04912 | 0.00644602944709 | 0.5 | MAPK12 MAPK13 | GnRH signaling pathway |
| KEGG:04914 | 0.00644602944709 | 0.5 | MAPK12 MAPK13 | Progesterone-mediated oocyte maturation |
| KEGG:04659 | 0.00726841321698 | 0.5 | MAPK12 MAPK13 | Th17 cell differentiation |
| KEGG:04620 | 0.00726841321698 | 0.5 | MAPK12 MAPK13 | Toll-like receptor signaling pathway |
| KEGG:04670 | 0.00761107721317 | 0.5 | MAPK12 MAPK13 | Leukocyte transendothelial migration |
| KEGG:04625 | 0.00761107721317 | 0.5 | MAPK12 MAPK13 | C-type lectin receptor signaling pathway |
| KEGG:05142 | 0.00761107721317 | 0.5 | MAPK12 MAPK13 | Chagas disease (American trypanosomiasis) |
| KEGG:01522 | 0.00796156937098 | 0.5 | MAPK12 MAPK13 | Endocrine resistance |
| KEGG:04660 | 0.00796156937098 | 0.5 | MAPK12 MAPK13 | T cell receptor signaling pathway |
| KEGG:04933 | 0.00813974967686 | 0.5 | MAPK12 MAPK13 | AGE-RAGE signaling pathway in diabetic complications |
| WP:WP4321 | 0.00824363937234 | 0.5 | MAPK12 MAPK13 | Thermogenesis |
| KEGG:04668 | 0.00850197607578 | 0.5 | MAPK12 MAPK13 | TNF signaling pathway |
| KEGG:05145 | 0.00868602110226 | 0.5 | MAPK12 MAPK13 | Toxoplasmosis |
| REAC:R-HSA-373752 | 0.00991669978918 | 0.5 | MAPK12 MAPK13 | Netrin-1 signaling |
| KEGG:04380 | 0.0104302851929 | 0.5 | MAPK12 MAPK13 | Osteoclast differentiation |
| KEGG:04722 | 0.0112562119133 | 0.5 | MAPK12 MAPK13 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.0112562119133 | 0.5 | MAPK12 MAPK13 | Oocyte meiosis |
| WP:WP1449 | 0.0114775392713 | 0.5 | MAPK12 MAPK13 | Regulation of toll-like receptor signaling pathway |
| KEGG:04071 | 0.0116808588864 | 0.5 | MAPK12 MAPK13 | Sphingolipid signaling pathway |
| KEGG:05135 | 0.0123324218825 | 0.5 | MAPK12 MAPK13 | Yersinia infection |
| WP:WP3915 | 0.012672821387 | 0.5 | MAPK12 MAPK13 | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04068 | 0.012776519361 | 0.5 | MAPK12 MAPK13 | FoxO signaling pathway |
| REAC:R-HSA-168643 | 0.0137933430055 | 0.5 | MAPK12 MAPK13 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04926 | 0.0141554312811 | 0.5 | MAPK12 MAPK13 | Relaxin signaling pathway |
| KEGG:04728 | 0.014392043024 | 0.5 | MAPK12 MAPK13 | Dopaminergic synapse |
| KEGG:04550 | 0.0148710843718 | 0.5 | MAPK12 MAPK13 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP4239 | 0.015016032698 | 0.5 | MAPK12 MAPK13 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:05418 | 0.0153578793248 | 0.5 | MAPK12 MAPK13 | Fluid shear stress and atherosclerosis |
| KEGG:04261 | 0.0163547130378 | 0.5 | MAPK12 MAPK13 | Adrenergic signaling in cardiomyocytes |
| KEGG:04723 | 0.0171226599156 | 0.5 | MAPK12 MAPK13 | Retrograde endocannabinoid signaling |
| WP:WP4666 | 0.0173163427152 | 0.5 | MAPK12 MAPK13 | Hepatitis B infection |
| WP:WP481 | 0.0195247658454 | 0.5 | MAPK12 MAPK13 | Insulin Signaling |
| KEGG:04218 | 0.0206513420529 | 0.5 | MAPK12 MAPK13 | Cellular senescence |
| KEGG:05152 | 0.0220952935316 | 0.5 | MAPK12 MAPK13 | Tuberculosis |
| KEGG:05161 | 0.0235873467107 | 0.5 | MAPK12 MAPK13 | Hepatitis B |
| KEGG:04621 | 0.0245056398731 | 0.5 | MAPK12 MAPK13 | NOD-like receptor signaling pathway |
| REAC:R-HSA-187037 | 0.0262582706021 | 0.5 | MAPK12 MAPK13 | Signaling by NTRK1 (TRKA) |
| KEGG:05167 | 0.0267154932054 | 0.5 | MAPK12 MAPK13 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04015 | 0.0293559966201 | 0.5 | MAPK12 MAPK13 | Rap1 signaling pathway |
| KEGG:05130 | 0.0307221505972 | 0.5 | MAPK12 MAPK13 | Pathogenic Escherichia coli infection |
| KEGG:05169 | 0.0328286642151 | 0.5 | MAPK12 MAPK13 | Epstein-Barr virus infection |
| KEGG:05205 | 0.03463652866 | 0.5 | MAPK12 MAPK13 | Proteoglycans in cancer |
| KEGG:05170 | 0.0387812861874 | 0.5 | MAPK12 MAPK13 | Human immunodeficiency virus 1 infection |
| WP:WP382 | 0.0393304030404 | 0.5 | MAPK12 MAPK13 | MAPK Signaling Pathway |
| KEGG:05163 | 0.0399515654372 | 0.5 | MAPK12 MAPK13 | Human cytomegalovirus infection |
| REAC:R-HSA-166520 | 0.0408500448467 | 0.5 | MAPK12 MAPK13 | Signaling by NTRKs |
| REAC:R-HSA-4420097 | 0.0408500448467 | 0.5 | MAPK12 MAPK13 | VEGFA-VEGFR2 Pathway |
| KEGG:04714 | 0.0427485725169 | 0.5 | MAPK12 MAPK13 | Thermogenesis |
| REAC:R-HSA-194138 | 0.0483568152087 | 0.5 | MAPK12 MAPK13 | Signaling by VEGF |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPK12 | MAPK13 | 0.989 | 0.905 | bioplex (MAPK12) bioplex_WMM |
| TANC1 | MAPK12 | 0.139 | 0.407 | bioplex (MAPK12) bioplex_WMM |
| MYLK3 | MAPK12 | 0.079 | 0.353 | bioplex (MAPK12) bioplex_WMM |
| MYLK3 | MAPK13 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| TANC1 | MAPK13 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| TANC1 | MYLK3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00819 has an average edge precision of 0.324 which is ranked 4294 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK12 | HuMAP2_00819 HuMAP2_05159 |
| MAPK13 | HuMAP2_00819 HuMAP2_05159 |
| TANC1 | HuMAP2_00819 |
| MYLK3 | HuMAP2_00819 HuMAP2_01116 |