hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00820
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GLRX3 | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | UniProt NCBI |
| BOLA1 | BolA-like protein 1 (hBolA) | UniProt NCBI |
| STAM | Signal transducing adapter molecule 1 (STAM-1) | UniProt NCBI |
| HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | UniProt NCBI |
| STAM2 | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | UniProt NCBI |
| HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0033565 | 1.81637152046e-06 | 0.5 | STAM HGS STAM2 | ESCRT-0 complex |
| REAC:R-HSA-8875360 | 2.16413418261e-06 | 0.5 | STAM HGS STAM2 | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 5.75676182894e-06 | 0.5 | STAM HGS STAM2 | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 6.77163692478e-06 | 0.5 | STAM HGS STAM2 | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 1.36517474966e-05 | 0.5 | STAM HGS STAM2 | EGFR downregulation |
| CORUM:3677 | 2.51655344529e-05 | 0.333333333333 | HGS STAM2 | RIN1-STAM2-HRS complex |
| CORUM:7287 | 2.51655344529e-05 | 0.333333333333 | STAM HGS | SIMPLE-HRS-STAM1 complex |
| REAC:R-HSA-917729 | 2.6656058306e-05 | 0.5 | STAM HGS STAM2 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| REAC:R-HSA-177929 | 7.30512953501e-05 | 0.5 | STAM HGS STAM2 | Signaling by EGFR |
| REAC:R-HSA-6806834 | 0.00036649373235 | 0.5 | STAM HGS STAM2 | Signaling by MET |
| REAC:R-HSA-8856825 | 0.000667561375412 | 0.5 | STAM HGS STAM2 | Cargo recognition for clathrin-mediated endocytosis |
| WP:WP437 | 0.000981982556245 | 0.5 | STAM HGS STAM2 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-8856828 | 0.00204204589337 | 0.5 | STAM HGS STAM2 | Clathrin-mediated endocytosis |
| KEGG:04144 | 0.00329433483006 | 0.5 | STAM HGS STAM2 | Endocytosis |
| GO:0036452 | 0.00416378298645 | 0.5 | STAM HGS STAM2 | ESCRT complex |
| GO:0036258 | 0.00734442516369 | 0.5 | STAM HGS STAM2 | multivesicular body assembly |
| GO:0036257 | 0.00813009778332 | 0.5 | STAM HGS STAM2 | multivesicular body organization |
| GO:0042059 | 0.0152420239566 | 0.5 | STAM HGS STAM2 | negative regulation of epidermal growth factor receptor signaling pathway |
| REAC:R-HSA-5688426 | 0.0177470475827 | 0.5 | STAM HGS STAM2 | Deubiquitination |
| GO:1901185 | 0.0207293189685 | 0.5 | STAM HGS STAM2 | negative regulation of ERBB signaling pathway |
| CORUM:6958 | 0.0249904952816 | 0.166666666667 | GLRX3 | BOLA2-GLRX3 complex |
| REAC:R-HSA-1643685 | 0.0363076318173 | 0.666666666667 | STAM2 STAM HGS HSPG2 | Disease |
| REAC:R-HSA-5663205 | 0.0427834850779 | 0.5 | STAM HGS STAM2 | Infectious disease |
| KEGG:04630 | 0.0444979624084 | 0.333333333333 | STAM STAM2 | JAK-STAT signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STAM | HGS | 1.0 | 0.949 | bioplex (STAM) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| HGS | STAM2 | 0.988 | 0.901 | Guru youn_WMM Malo gupta_WMM fraction |
| BOLA1 | GLRX3 | 0.189 | 0.441 | bioplex (BOLA1,GLRX3) bioplex_WMM |
| GLRX3 | STAM | 0.163 | 0.42 | youn_WMM gupta_WMM fraction |
| GLRX3 | STAM2 | 0.112 | 0.381 | youn_WMM gupta_WMM fraction |
| GLRX3 | HSPG2 | 0.05 | 0.294 | fraction |
| STAM | STAM2 | 0.008 | 0.07 | youn_WMM gupta_WMM WMM_only |
| GLRX3 | HGS | 0.007 | 0.001 | youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_00820 has an average edge precision of 0.432 which is ranked 3002 out of all 6965 complexes.
Related Complexes