hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00825
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | UniProt NCBI |
| TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | UniProt NCBI |
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 1.81514593393e-13 | 0.8 | POLB XRCC1 LIG3 PNKP | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| CORUM:5243 | 1.81514593393e-13 | 0.8 | PNKP XRCC1 LIG3 TDP1 | XRCC1-LIG3-PNK-TDP1 complex |
| REAC:R-HSA-5649702 | 5.47745657224e-12 | 0.8 | POLB XRCC1 LIG3 PNKP | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| CORUM:1086 | 5.40532307664e-09 | 0.6 | XRCC1 LIG3 POLB | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-110381 | 1.08753805614e-08 | 0.6 | XRCC1 LIG3 POLB | Resolution of AP sites via the single-nucleotide replacement pathway |
| CORUM:1085 | 1.35119464053e-08 | 0.6 | XRCC1 LIG3 POLB | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-73933 | 1.90901811802e-08 | 0.8 | POLB XRCC1 LIG3 PNKP | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-73894 | 6.75134786288e-07 | 1.0 | PNKP XRCC1 POLB LIG3 TDP1 | DNA Repair |
| REAC:R-HSA-73884 | 8.09278526697e-07 | 0.8 | POLB XRCC1 LIG3 PNKP | Base Excision Repair |
| GO:0006288 | 9.08185760231e-07 | 0.6 | XRCC1 LIG3 POLB | base-excision repair, DNA ligation |
| KEGG:03410 | 4.27757362181e-06 | 0.6 | XRCC1 LIG3 POLB | Base excision repair |
| CORUM:363 | 6.70868171695e-06 | 0.4 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:212 | 6.70868171695e-06 | 0.4 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 6.70868171695e-06 | 0.4 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| GO:0051103 | 5.0832789986e-05 | 0.6 | XRCC1 LIG3 POLB | DNA ligation involved in DNA repair |
| HP:0007141 | 0.000272465709143 | 0.6 | XRCC1 PNKP TDP1 | Sensorimotor neuropathy |
| GO:0006266 | 0.000507918241599 | 0.6 | XRCC1 LIG3 POLB | DNA ligation |
| REAC:R-HSA-5685939 | 0.000606744453221 | 0.4 | XRCC1 LIG3 | HDR through MMEJ (alt-NHEJ) |
| GO:0006281 | 0.00130222282902 | 1.0 | PNKP XRCC1 POLB LIG3 TDP1 | DNA repair |
| REAC:R-HSA-5693532 | 0.00193087050228 | 0.6 | XRCC1 LIG3 TDP1 | DNA Double-Strand Break Repair |
| HP:0002460 | 0.00395790532612 | 0.6 | XRCC1 PNKP TDP1 | Distal muscle weakness |
| REAC:R-HSA-5696397 | 0.0040368179849 | 0.4 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| HPA:004030_13 | 0.00570992332484 | 0.6 | XRCC1 LIG3 PNKP | breast; myoepithelial cells[Supported,High] |
| HPA:043020_13 | 0.0070287335521 | 0.6 | XRCC1 LIG3 PNKP | skin 1; fibroblasts[Supported,High] |
| GO:0006284 | 0.00763446836913 | 0.6 | XRCC1 LIG3 POLB | base-excision repair |
| HP:0003474 | 0.00938943928499 | 0.6 | XRCC1 PNKP TDP1 | Sensory impairment |
| WP:WP4016 | 0.00992634522128 | 0.4 | TDP1 POLB | DNA IR-damage and cellular response via ATR |
| GO:0006259 | 0.0122301485616 | 1.0 | PNKP XRCC1 POLB LIG3 TDP1 | DNA metabolic process |
| HP:0001284 | 0.0122356792032 | 0.6 | XRCC1 PNKP TDP1 | Areflexia |
| GO:0006974 | 0.0123166418329 | 1.0 | PNKP XRCC1 POLB LIG3 TDP1 | cellular response to DNA damage stimulus |
| HPA:047040_12 | 0.0127599080481 | 0.6 | XRCC1 LIG3 PNKP | soft tissue 1; peripheral nerve[Supported,Medium] |
| HPA:035010_13 | 0.0128832808935 | 0.6 | XRCC1 LIG3 PNKP | placenta; decidual cells[Supported,High] |
| GO:0006302 | 0.0134490676813 | 0.8 | POLB XRCC1 LIG3 TDP1 | double-strand break repair |
| GO:0098502 | 0.0135228859698 | 0.4 | POLB PNKP | DNA dephosphorylation |
| GO:0010836 | 0.0135228859698 | 0.4 | XRCC1 PNKP | negative regulation of protein ADP-ribosylation |
| HPA:014020_13 | 0.0138986902566 | 0.6 | XRCC1 LIG3 PNKP | endometrium 2; glandular cells[Supported,High] |
| HPA:007030_13 | 0.0155185477857 | 0.6 | XRCC1 LIG3 PNKP | cerebellum; cells in molecular layer[Supported,High] |
| HPA:004020_13 | 0.017108483906 | 0.6 | XRCC1 LIG3 PNKP | breast; glandular cells[Supported,High] |
| HPA:009010_13 | 0.0174086151451 | 0.6 | XRCC1 LIG3 PNKP | cervix, uterine; glandular cells[Supported,High] |
| HPA:013020_13 | 0.0180192386998 | 0.6 | XRCC1 LIG3 PNKP | endometrium 1; glandular cells[Supported,High] |
| HP:0010831 | 0.0215275853758 | 0.4 | XRCC1 TDP1 | Impaired proprioception |
| HPA:044010_13 | 0.0234185559543 | 0.6 | XRCC1 LIG3 PNKP | skin 2; epidermal cells[Supported,High] |
| HPA:004030_03 | 0.0249166933231 | 0.6 | XRCC1 LIG3 PNKP | breast; myoepithelial cells[Uncertain,High] |
| REAC:R-HSA-6782210 | 0.0269854937899 | 0.4 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| HPA:043020_03 | 0.0278928770515 | 0.6 | XRCC1 LIG3 PNKP | skin 1; fibroblasts[Uncertain,High] |
| HPA:003010_13 | 0.0280991888292 | 0.6 | XRCC1 LIG3 PNKP | bone marrow; hematopoietic cells[Supported,High] |
| HPA:008030_13 | 0.0302177023038 | 0.6 | XRCC1 LIG3 PNKP | cerebral cortex; neuronal cells[Supported,High] |
| HPA:015010_13 | 0.0315377734332 | 0.6 | XRCC1 LIG3 PNKP | epididymis; glandular cells[Supported,High] |
| HPA:007030_03 | 0.0384529972986 | 0.6 | XRCC1 LIG3 PNKP | cerebellum; cells in molecular layer[Uncertain,High] |
| HPA:055010_13 | 0.0397374089383 | 0.6 | XRCC1 LIG3 PNKP | thyroid gland; glandular cells[Supported,High] |
| HP:0009053 | 0.0398018408038 | 0.4 | TDP1 PNKP | Distal lower limb muscle weakness |
| HPA:053020_13 | 0.0399976212256 | 0.6 | XRCC1 LIG3 PNKP | testis; cells in seminiferous ducts[Supported,High] |
| REAC:R-HSA-6781827 | 0.0401214552357 | 0.4 | XRCC1 LIG3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HPA:014010_12 | 0.0432077883482 | 0.6 | XRCC1 LIG3 PNKP | endometrium 2; cells in endometrial stroma[Supported,Medium] |
| HPA:047040_11 | 0.0434826712222 | 0.6 | XRCC1 LIG3 PNKP | soft tissue 1; peripheral nerve[Supported,Low] |
| HPA:035010_03 | 0.0434826712222 | 0.6 | XRCC1 LIG3 PNKP | placenta; decidual cells[Uncertain,High] |
| HPA:057010_13 | 0.0437586981176 | 0.6 | XRCC1 LIG3 PNKP | urinary bladder; urothelial cells[Supported,High] |
| REAC:R-HSA-5696399 | 0.0465369402216 | 0.4 | XRCC1 LIG3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HPA:032010_13 | 0.0468711310654 | 0.6 | XRCC1 LIG3 PNKP | pancreas; exocrine glandular cells[Supported,High] |
| CORUM:0000000 | 0.0474603483533 | 1.0 | PNKP XRCC1 POLB LIG3 TDP1 | CORUM root |
| HPA:018010_13 | 0.0486283293616 | 0.6 | XRCC1 LIG3 PNKP | fallopian tube; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0489253257786 | 0.6 | XRCC1 LIG3 PNKP | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0492235080566 | 0.6 | XRCC1 LIG3 PNKP | bronchus; respiratory epithelial cells[Supported,High] |
| CORUM:213 | 0.0499494897235 | 0.2 | XRCC1 | DNA ligase IV-XRCC1 complex |
| CORUM:7352 | 0.0499494897235 | 0.2 | LIG3 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC1 | POLB | 1.0 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM hein (XRCC1) |
| POLB | LIG3 | 0.999 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM |
| POLB | TDP1 | 0.929 | 0.845 | bioplex (POLB) bioplex_WMM |
| POLB | PNKP | 0.882 | 0.818 | hein_WMM bioplex (POLB) bioplex_WMM |
| XRCC1 | LIG3 | 0.186 | 0.441 | hein_WMM bioplex_WMM youn_WMM hein (XRCC1) gupta_WMM |
| XRCC1 | PNKP | 0.012 | 0.15 | hein_WMM bioplex_WMM hein (XRCC1) |
| XRCC1 | TDP1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| LIG3 | TDP1 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| LIG3 | PNKP | 0.008 | 0.081 | hein_WMM bioplex_WMM WMM_only |
| PNKP | TDP1 | 0.008 | 0.062 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00825 has an average edge precision of 0.45 which is ranked 2874 out of all 6965 complexes.
Related Complexes