hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00828
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | UniProt NCBI |
| SLF1 | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) | UniProt NCBI |
| SLF2 | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | UniProt NCBI |
| SMC5 | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | UniProt NCBI |
| NSMCE4A | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | UniProt NCBI |
| NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27) | UniProt NCBI |
| NSMCE2 | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | UniProt NCBI |
| SMC6 | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | UniProt NCBI |
| SIMC1 | SUMO-interacting motif-containing protein 1 | UniProt NCBI |
| EID3 | EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030915 | 1.86257928622e-19 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | Smc5-Smc6 complex |
| GO:0106068 | 1.86257928622e-19 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | SUMO ligase complex |
| REAC:R-HSA-3108214 | 1.02476093069e-12 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-3108232 | 4.59344559356e-10 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 5.90995903642e-10 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | SUMOylation |
| GO:0000793 | 7.05972874285e-09 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | condensed chromosome |
| GO:0034184 | 2.56070819562e-08 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of maintenance of mitotic sister chromatid cohesion |
| GO:0034093 | 2.56070819562e-08 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of maintenance of sister chromatid cohesion |
| GO:0051984 | 1.09067223824e-07 | 0.5 | SLF1 SLF2 SMC5 NSMCE2 SMC6 | positive regulation of chromosome segregation |
| GO:0034091 | 3.58152528008e-07 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | regulation of maintenance of sister chromatid cohesion |
| GO:0034182 | 3.58152528008e-07 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | regulation of maintenance of mitotic sister chromatid cohesion |
| GO:0006259 | 5.87259406467e-07 | 0.9 | NSMCE2 SMC6 NSMCE4A SMC5 EID3 SLF1 NSMCE3 NSMCE1 SLF2 | DNA metabolic process |
| GO:0006974 | 5.94740106977e-07 | 0.9 | NSMCE2 SMC6 NSMCE4A SMC5 EID3 SLF1 NSMCE3 NSMCE1 SLF2 | cellular response to DNA damage stimulus |
| GO:0045876 | 6.4446669519e-07 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of sister chromatid cohesion |
| GO:0006281 | 1.52275413109e-06 | 0.8 | NSMCE2 NSMCE4A SMC5 EID3 SLF1 NSMCE3 NSMCE1 SLF2 | DNA repair |
| GO:0034088 | 2.52938509427e-06 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | maintenance of mitotic sister chromatid cohesion |
| GO:0034086 | 2.52938509427e-06 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | maintenance of sister chromatid cohesion |
| GO:0062033 | 9.28797042186e-06 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of mitotic sister chromatid segregation |
| GO:0007063 | 2.46935086017e-05 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | regulation of sister chromatid cohesion |
| GO:0007064 | 3.0493905917e-05 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | mitotic sister chromatid cohesion |
| GO:0044427 | 7.653029207e-05 | 0.9 | NSMCE2 SMC6 NSMCE4A SMC5 EID3 SLF1 NSMCE3 NSMCE1 SLF2 | chromosomal part |
| GO:2001022 | 8.36918481056e-05 | 0.5 | NSMCE4A SLF1 NSMCE1 EID3 SLF2 | positive regulation of response to DNA damage stimulus |
| GO:0051983 | 8.85899956338e-05 | 0.5 | SLF1 SLF2 SMC5 NSMCE2 SMC6 | regulation of chromosome segregation |
| GO:0005694 | 0.000105741912425 | 0.9 | NSMCE2 SMC6 NSMCE4A SMC5 EID3 SLF1 NSMCE3 NSMCE1 SLF2 | chromosome |
| GO:0045840 | 0.000298674788131 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of mitotic nuclear division |
| GO:0051785 | 0.000512656045765 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of nuclear division |
| REAC:R-HSA-597592 | 0.000606384182679 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | Post-translational protein modification |
| GO:0033554 | 0.00068889340822 | 0.9 | NSMCE2 SMC6 NSMCE4A SMC5 EID3 SLF1 NSMCE3 NSMCE1 SLF2 | cellular response to stress |
| GO:0007062 | 0.000982792060055 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | sister chromatid cohesion |
| GO:0000722 | 0.00130456308183 | 0.3 | SMC6 SMC5 NSMCE2 | telomere maintenance via recombination |
| GO:0035861 | 0.00171872239287 | 0.4 | SLF1 SLF2 SMC5 SMC6 | site of double-strand break |
| GO:0033047 | 0.00245343460581 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | regulation of mitotic sister chromatid segregation |
| GO:1990234 | 0.00258148885418 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | transferase complex |
| GO:2001020 | 0.00300826511184 | 0.5 | NSMCE4A SLF1 NSMCE1 EID3 SLF2 | regulation of response to DNA damage stimulus |
| GO:0033045 | 0.00459827964391 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | regulation of sister chromatid segregation |
| GO:0090734 | 0.00545324499353 | 0.4 | SLF1 SLF2 SMC5 SMC6 | site of DNA damage |
| REAC:R-HSA-392499 | 0.00692992953232 | 0.7 | NSMCE4A EID3 SMC5 SMC6 NSMCE3 NSMCE2 NSMCE1 | Metabolism of proteins |
| GO:0006312 | 0.00737429365883 | 0.3 | SMC6 SMC5 NSMCE2 | mitotic recombination |
| GO:0006302 | 0.00973448831007 | 0.5 | SLF1 NSMCE1 SMC5 NSMCE2 SLF2 | double-strand break repair |
| GO:0007059 | 0.0156697718281 | 0.5 | SLF1 SLF2 SMC5 NSMCE2 SMC6 | chromosome segregation |
| GO:0045931 | 0.025572748322 | 0.4 | SLF1 SMC5 NSMCE2 SLF2 | positive regulation of mitotic cell cycle |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMC6 | NSMCE1 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM hein (SMC6) Malo fraction |
| NSMCE1 | SMC5 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM Malo fraction |
| NSMCE1 | NSMCE2 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM Malo fraction |
| NSMCE1 | NSMCE3 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM Malo fraction |
| SMC6 | NSMCE3 | 0.999 | 0.948 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| SMC5 | NSMCE3 | 0.995 | 0.924 | hein_WMM bioplex_WMM Malo fraction |
| SMC6 | SMC5 | 0.991 | 0.911 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| SMC6 | NSMCE2 | 0.99 | 0.909 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| NSMCE3 | NSMCE2 | 0.966 | 0.875 | hein_WMM bioplex_WMM Malo fraction |
| NSMCE1 | NSMCE4A | 0.961 | 0.869 | hein_WMM bioplex (NSMCE1,NSMCE4A) bioplex_WMM |
| SMC5 | NSMCE2 | 0.886 | 0.817 | hein_WMM bioplex_WMM Malo fraction |
| NSMCE3 | NSMCE4A | 0.88 | 0.814 | hein_WMM bioplex (NSMCE4A) bioplex_WMM |
| SMC6 | NSMCE4A | 0.408 | 0.567 | hein_WMM bioplex (NSMCE4A) bioplex_WMM hein (SMC6) |
| NSMCE1 | SLF2 | 0.185 | 0.437 | hein_WMM bioplex (NSMCE1) bioplex_WMM |
| NSMCE3 | EID3 | 0.092 | 0.356 | bioplex (EID3) bioplex_WMM |
| NSMCE1 | SIMC1 | 0.079 | 0.351 | bioplex (NSMCE1) bioplex_WMM |
| NSMCE1 | EID3 | 0.072 | 0.356 | bioplex (EID3) bioplex_WMM |
| SMC5 | EID3 | 0.063 | 0.347 | bioplex (EID3) bioplex_WMM |
| NSMCE2 | EID3 | 0.04 | 0.268 | bioplex (EID3) bioplex_WMM |
| SLF1 | SLF2 | 0.035 | 0.265 | hein_WMM youn_WMM hein (SLF2) |
| NSMCE4A | NSMCE2 | 0.023 | 0.209 | hein_WMM bioplex (NSMCE4A) bioplex_WMM |
| SMC6 | SLF2 | 0.022 | 0.206 | hein_WMM bioplex_WMM hein (SMC6) |
| NSMCE3 | SLF2 | 0.01 | 0.106 | hein_WMM bioplex_WMM WMM_only |
| NSMCE4A | SLF2 | 0.009 | 0.113 | hein_WMM bioplex_WMM WMM_only |
| SMC5 | SLF2 | 0.009 | 0.109 | hein_WMM bioplex_WMM WMM_only |
| SMC6 | SLF1 | 0.009 | 0.109 | hein_WMM hein (SMC6) |
| NSMCE2 | SLF2 | 0.009 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| SLF2 | SIMC1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| NSMCE1 | SLF1 | 0.008 | 0.023 | hein_WMM WMM_only |
| NSMCE4A | SLF1 | 0.008 | 0.023 | hein_WMM WMM_only |
| NSMCE3 | SLF1 | 0.008 | 0.023 | hein_WMM WMM_only |
| SMC5 | SIMC1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| NSMCE2 | SIMC1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| NSMCE3 | SIMC1 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| SMC6 | SIMC1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| SMC5 | SLF1 | 0.007 | 0.006 | hein_WMM WMM_only |
| NSMCE4A | SIMC1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| NSMCE2 | SLF1 | 0.007 | 0.007 | hein_WMM WMM_only |
| SMC6 | EID3 | 0.006 | 0.002 | bioplex (EID3) bioplex_WMM |
| SMC5 | NSMCE4A | 0.0 | 0.001 | hein_WMM bioplex (NSMCE4A) bioplex_WMM |
Images
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Complex HuMAP2_00828 has an average edge precision of 0.373 which is ranked 3600 out of all 6965 complexes.
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