hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00829
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNMBP | Dynamin-binding protein (Scaffold protein Tuba) | UniProt NCBI |
| SNX9 | Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A) | UniProt NCBI |
| RABIF | Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) | UniProt NCBI |
| DNM2 | Dynamin-2 (EC 3.6.5.5) | UniProt NCBI |
| DNM1 | Dynamin-1 (EC 3.6.5.5) | UniProt NCBI |
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 1.70064822019e-06 | 0.5 | DNM1 DNM2 DNM3 | Retrograde neurotrophin signalling |
| GO:0098844 | 7.26438828159e-06 | 0.5 | DNM1 DNM2 DNM3 | postsynaptic endocytic zone membrane |
| REAC:R-HSA-8856828 | 1.30320445382e-05 | 0.666666666667 | SNX9 DNM3 DNM2 DNM1 | Clathrin-mediated endocytosis |
| GO:0044327 | 1.81582264982e-05 | 0.5 | DNM1 DNM2 DNM3 | dendritic spine head |
| WP:WP2267 | 2.26394868464e-05 | 0.5 | DNM1 DNM2 DNM3 | Synaptic Vesicle Pathway |
| KEGG:04961 | 3.27302617765e-05 | 0.5 | DNM1 DNM2 DNM3 | Endocrine and other factor-regulated calcium reabsorption |
| GO:0016185 | 3.63109651748e-05 | 0.5 | DNM1 DNM2 DNM3 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0140239 | 3.63109651748e-05 | 0.5 | DNM1 DNM2 DNM3 | postsynaptic endocytosis |
| GO:0098884 | 3.63109651748e-05 | 0.5 | DNM1 DNM2 DNM3 | postsynaptic neurotransmitter receptor internalization |
| GO:0098843 | 6.35345863999e-05 | 0.5 | DNM1 DNM2 DNM3 | postsynaptic endocytic zone |
| GO:0070142 | 6.35345863999e-05 | 0.5 | DNM1 DNM2 DNM3 | synaptic vesicle budding |
| KEGG:04721 | 7.9791370908e-05 | 0.5 | DNM1 DNM2 DNM3 | Synaptic vesicle cycle |
| REAC:R-HSA-437239 | 8.3970836606e-05 | 0.5 | DNM1 DNM2 DNM3 | Recycling pathway of L1 |
| KEGG:05100 | 0.000103500544784 | 0.5 | DNM1 DNM2 DNM3 | Bacterial invasion of epithelial cells |
| GO:0099590 | 0.000217734118711 | 0.5 | DNM1 DNM2 DNM3 | neurotransmitter receptor internalization |
| REAC:R-HSA-187037 | 0.00036649373235 | 0.5 | DNM1 DNM2 DNM3 | Signaling by NTRK1 (TRKA) |
| KEGG:04072 | 0.000537326639668 | 0.5 | DNM1 DNM2 DNM3 | Phospholipase D signaling pathway |
| REAC:R-HSA-166520 | 0.000713906652255 | 0.5 | DNM1 DNM2 DNM3 | Signaling by NTRKs |
| REAC:R-HSA-196025 | 0.0012174763081 | 0.333333333333 | DNM1 DNM2 | Formation of annular gap junctions |
| REAC:R-HSA-373760 | 0.00129954570423 | 0.5 | DNM1 DNM2 DNM3 | L1CAM interactions |
| REAC:R-HSA-190873 | 0.00146070989197 | 0.333333333333 | DNM1 DNM2 | Gap junction degradation |
| REAC:R-HSA-2132295 | 0.00148381707922 | 0.5 | DNM1 DNM2 DNM3 | MHC class II antigen presentation |
| REAC:R-HSA-166016 | 0.00156211728615 | 0.5 | DNM1 DNM2 DNM3 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-168898 | 0.00261070612174 | 0.5 | DNM1 DNM2 DNM3 | Toll-like Receptor Cascades |
| KEGG:04144 | 0.00329433483006 | 0.5 | DNM1 DNM2 DNM3 | Endocytosis |
| GO:0099637 | 0.00470617323084 | 0.5 | DNM1 DNM2 DNM3 | neurotransmitter receptor transport |
| GO:0099072 | 0.00529364410104 | 0.5 | DNM1 DNM2 DNM3 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| REAC:R-HSA-199991 | 0.00529378407845 | 0.666666666667 | SNX9 DNM3 DNM2 DNM1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00654030934977 | 0.666666666667 | SNX9 DNM3 DNM2 DNM1 | Vesicle-mediated transport |
| GO:0000266 | 0.00661098268806 | 0.5 | DNM1 DNM2 DNM3 | mitochondrial fission |
| GO:0048489 | 0.0108183376095 | 0.5 | DNM1 DNM2 DNM3 | synaptic vesicle transport |
| GO:0048488 | 0.0118307664632 | 0.5 | DNM1 DNM2 DNM3 | synaptic vesicle endocytosis |
| GO:0140238 | 0.0118307664632 | 0.5 | DNM1 DNM2 DNM3 | presynaptic endocytosis |
| REAC:R-HSA-190828 | 0.012367185342 | 0.333333333333 | DNM1 DNM2 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.0131143608537 | 0.333333333333 | DNM1 DNM2 | Gap junction trafficking and regulation |
| GO:0006898 | 0.0165870922979 | 0.666666666667 | SNX9 DNM3 DNM2 DNM1 | receptor-mediated endocytosis |
| GO:0097479 | 0.0178456165824 | 0.5 | DNM1 DNM2 DNM3 | synaptic vesicle localization |
| GO:0036465 | 0.0222806450818 | 0.5 | DNM1 DNM2 DNM3 | synaptic vesicle recycling |
| REAC:R-HSA-432722 | 0.0314333263146 | 0.333333333333 | SNX9 DNM2 | Golgi Associated Vesicle Biogenesis |
| GO:0061024 | 0.0348007912331 | 0.833333333333 | SNX9 DNM3 DNM2 DNM1 RABIF | membrane organization |
| WP:WP4549 | 0.0358990321007 | 0.333333333333 | DNM1 DNM2 | Fragile X Syndrome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DNM2 | DNM3 | 0.994 | 0.921 | bioplex (DNM3) bioplex_WMM |
| DNM1 | DNM3 | 0.955 | 0.862 | bioplex (DNM3) bioplex_WMM |
| SNX9 | DNM1 | 0.134 | 0.406 | bioplex (SNX9) bioplex_WMM youn_WMM |
| SNX9 | DNM3 | 0.057 | 0.321 | bioplex (SNX9) bioplex_WMM |
| DNM3 | DNMBP | 0.029 | 0.232 | bioplex (DNM3) bioplex_WMM |
| RABIF | DNM1 | 0.024 | 0.214 | bioplex_WMM fraction |
| DNM2 | DNM1 | 0.011 | 0.148 | bioplex_WMM youn_WMM WMM_only |
| SNX9 | DNM2 | 0.009 | 0.104 | bioplex (SNX9) bioplex_WMM youn_WMM gupta_WMM |
| SNX9 | DNMBP | 0.008 | 0.06 | hein_WMM youn_WMM gupta_WMM WMM_only |
| DNM2 | DNMBP | 0.007 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DNM1 | DNMBP | 0.007 | 0.0 | bioplex_WMM youn_WMM WMM_only |
| RABIF | DNM3 | 0.003 | 0.011 | bioplex_WMM fraction |
| DNM2 | RABIF | 0.0 | 0.007 | bioplex_WMM fraction |
Images
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Complex HuMAP2_00829 has an average edge precision of 0.253 which is ranked 5335 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DNMBP | HuMAP2_00829 HuMAP2_01896 |
| SNX9 | HuMAP2_00829 HuMAP2_00958 HuMAP2_02944 HuMAP2_03306 HuMAP2_06076 |
| RABIF | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 |
| DNM2 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM1 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM3 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |