hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00836
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ARHGEF35 | Rho guanine nucleotide exchange factor 35 (Rho guanine nucleotide exchange factor 5-like protein) | UniProt NCBI |
| ARHGEF5 | Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM) | UniProt NCBI |
| CNN2 | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) | UniProt NCBI |
| ALAD | Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-193648 | 0.0137933430055 | 0.5 | ARHGEF5 ARHGEF35 | NRAGE signals death through JNK |
| REAC:R-HSA-204998 | 0.0227713839361 | 0.5 | ARHGEF5 ARHGEF35 | Cell death signalling via NRAGE, NRIF and NADE |
| REAC:R-HSA-416482 | 0.0262582706021 | 0.5 | ARHGEF5 ARHGEF35 | G alpha (12/13) signalling events |
| REAC:R-HSA-193704 | 0.0364771667023 | 0.5 | ARHGEF5 ARHGEF35 | p75 NTR receptor-mediated signalling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ARHGEF35 | ARHGEF5 | 1.0 | 0.949 | bioplex (ARHGEF35) bioplex_WMM youn_WMM |
| ARHGEF35 | ALAD | 0.105 | 0.37 | bioplex (ARHGEF35) bioplex_WMM |
| CNN2 | ALAD | 0.046 | 0.293 | bioplex (CNN2) bioplex_WMM |
| ARHGEF5 | ALAD | 0.008 | 0.082 | bioplex_WMM WMM_only |
| ARHGEF5 | CNN2 | 0.007 | 0.001 | youn_WMM WMM_only |
| ARHGEF35 | CNN2 | 0.007 | 0.001 | youn_WMM WMM_only |
Images
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Complex HuMAP2_00836 has an average edge precision of 0.283 which is ranked 4843 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ARHGEF35 | HuMAP2_00836 HuMAP2_05100 |
| ARHGEF5 | HuMAP2_00836 HuMAP2_05100 |
| CNN2 | HuMAP2_00836 HuMAP2_03891 HuMAP2_04409 |
| ALAD | HuMAP2_00836 HuMAP2_03891 |