hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00839
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD3EAP | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CAST) (CD3E-associated protein) (RNA polymerase I-associated factor PAF49) | UniProt NCBI |
| POLR1E | DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53) | UniProt NCBI |
| POLR1A | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) | UniProt NCBI |
| POLR1B | DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) | UniProt NCBI |
| TWISTNB | DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73863 | 4.16736127297e-12 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA Polymerase I Transcription Termination |
| GO:0001054 | 1.05430112357e-11 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA polymerase I activity |
| GO:0005736 | 1.05430112357e-11 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA polymerase I complex |
| REAC:R-HSA-73762 | 3.76225081583e-11 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA Polymerase I Transcription Initiation |
| GO:0006362 | 9.72832400388e-10 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | transcription elongation from RNA polymerase I promoter |
| REAC:R-HSA-5250924 | 1.01804674096e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 1.07793184337e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA Polymerase I Promoter Escape |
| GO:0006363 | 1.39189866517e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | termination of RNA polymerase I transcription |
| GO:0006361 | 1.64965767724e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | transcription initiation from RNA polymerase I promoter |
| CORUM:5233 | 1.92670151163e-09 | 0.8 | POLR1A CD3EAP POLR1E POLR1B | TNF-alpha/NF-kappa B signaling complex 5 |
| REAC:R-HSA-5250913 | 2.25553992627e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 2.36831692258e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 2.73397441715e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 2.86541549489e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 3.00186385179e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA Polymerase I Transcription |
| KEGG:03020 | 3.1791735226e-09 | 0.8 | POLR1A TWISTNB POLR1E POLR1B | RNA polymerase |
| GO:0003899 | 3.57083680546e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | DNA-directed 5'-3' RNA polymerase activity |
| GO:0097747 | 5.39035410816e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA polymerase activity |
| GO:0034062 | 5.39035410816e-09 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | 5'-3' RNA polymerase activity |
| REAC:R-HSA-212165 | 1.2652202713e-08 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | Epigenetic regulation of gene expression |
| GO:0006360 | 4.10119532622e-08 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | transcription by RNA polymerase I |
| GO:0045815 | 4.10119532622e-08 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | positive regulation of gene expression, epigenetic |
| GO:0006353 | 1.23045493494e-07 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | DNA-templated transcription, termination |
| WP:WP4022 | 1.35209832475e-07 | 0.8 | POLR1A TWISTNB POLR1E POLR1B | Pyrimidine metabolism |
| GO:0055029 | 5.00723926593e-07 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 5.27937183473e-07 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | DNA-directed RNA polymerase complex |
| GO:0030880 | 6.16749937273e-07 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | RNA polymerase complex |
| GO:0006354 | 7.91017852143e-07 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | DNA-templated transcription, elongation |
| GO:0016779 | 1.0499160419e-06 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | nucleotidyltransferase activity |
| WP:WP405 | 7.14388071161e-06 | 0.6 | POLR1A POLR1E POLR1B | Eukaryotic Transcription Initiation |
| GO:0044452 | 8.09735865139e-06 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | nucleolar part |
| GO:0006352 | 2.5942147504e-05 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | DNA-templated transcription, initiation |
| GO:0061695 | 3.59850228871e-05 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | transferase complex, transferring phosphorus-containing groups |
| GO:0040029 | 0.000142444005625 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | regulation of gene expression, epigenetic |
| GO:0140098 | 0.000183142364866 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | catalytic activity, acting on RNA |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | Gene expression (Transcription) |
| GO:1990234 | 0.0112296002627 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | transferase complex |
| GO:0005730 | 0.0158782996664 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | nucleolus |
| GO:0016772 | 0.0188407727751 | 1.0 | POLR1A TWISTNB POLR1E CD3EAP POLR1B | transferase activity, transferring phosphorus-containing groups |
| CORUM:1558 | 0.0499494897235 | 0.2 | POLR1B | POLR1B-RRN3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLR1A | POLR1B | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (POLR1A) Malo fraction treiber_WMM |
| TWISTNB | POLR1A | 0.999 | 0.949 | hein_WMM bioplex (TWISTNB) bioplex_WMM hein (POLR1A) Malo fraction |
| TWISTNB | POLR1B | 0.937 | 0.85 | hein_WMM bioplex (TWISTNB) bioplex_WMM Malo fraction |
| POLR1A | CD3EAP | 0.743 | 0.739 | hein_WMM bioplex_WMM hein (POLR1A) |
| POLR1E | POLR1A | 0.721 | 0.732 | hein_WMM bioplex_WMM hein (POLR1A) |
| POLR1E | CD3EAP | 0.352 | 0.538 | hein_WMM bioplex_WMM Malo fraction |
| CD3EAP | POLR1B | 0.012 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| POLR1E | POLR1B | 0.01 | 0.119 | hein_WMM bioplex_WMM WMM_only |
| TWISTNB | CD3EAP | 0.008 | 0.034 | hein_WMM bioplex_WMM WMM_only |
| POLR1E | TWISTNB | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00839 has an average edge precision of 0.506 which is ranked 2466 out of all 6965 complexes.
Related Complexes