hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00843
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NAXE | NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (YjeF N-terminal domain-containing protein 1) (YjeF_N1) | UniProt NCBI |
| UBQLN4 | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | UniProt NCBI |
| MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | UniProt NCBI |
| FARS2 | Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS) | UniProt NCBI |
| TRAP1 | Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) | UniProt NCBI |
| ACSF3 | Acyl-CoA synthetase family member 3, mitochondrial (EC 6.2.1.-) | UniProt NCBI |
| ACOX1 | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] | UniProt NCBI |
| TXNDC17 | Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) | UniProt NCBI |
| IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | UniProt NCBI |
| GMPR | GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1) | UniProt NCBI |
| MTHFD1L | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | UniProt NCBI |
| NPEPL1 | Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) | UniProt NCBI |
| GMPR2 | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) | UniProt NCBI |
| IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0043648 | 0.000255147650301 | 0.357142857143 | IDH2 ACSF3 MTHFD1L IDH1 MTHFD1 | dicarboxylic acid metabolic process |
| KEGG:01100 | 0.000296967707212 | 0.571428571429 | ACOX1 ACSF3 IDH2 MTHFD1 IDH1 GMPR2 MTHFD1L GMPR | Metabolic pathways |
| WP:WP3585 | 0.00212623263092 | 0.142857142857 | IDH1 IDH2 | Cytosine methylation |
| REAC:R-HSA-1430728 | 0.00220390929179 | 0.642857142857 | TRAP1 ACSF3 IDH2 GMPR2 MTHFD1 IDH1 NAXE MTHFD1L GMPR | Metabolism |
| KEGG:04146 | 0.002279355682 | 0.214285714286 | IDH1 ACOX1 IDH2 | Peroxisome |
| GO:0044281 | 0.00299861635117 | 0.714285714286 | ACOX1 FARS2 ACSF3 IDH2 GMPR2 MTHFD1 IDH1 NAXE MTHFD1L GMPR | small molecule metabolic process |
| REAC:R-HSA-196854 | 0.00380695696511 | 0.285714285714 | NAXE MTHFD1L IDH1 MTHFD1 | Metabolism of vitamins and cofactors |
| KEGG:01210 | 0.00588162132255 | 0.142857142857 | IDH1 IDH2 | 2-Oxocarboxylic acid metabolism |
| KEGG:00670 | 0.0066132703265 | 0.142857142857 | MTHFD1 MTHFD1L | One carbon pool by folate |
| GO:0072522 | 0.00787824605366 | 0.357142857143 | GMPR2 MTHFD1L MTHFD1 GMPR ACSF3 | purine-containing compound biosynthetic process |
| KEGG:01200 | 0.00794323080628 | 0.214285714286 | IDH1 ACOX1 IDH2 | Carbon metabolism |
| HP:0006765 | 0.0095945740089 | 0.142857142857 | IDH1 IDH2 | Chondrosarcoma |
| REAC:R-HSA-74217 | 0.0136707417123 | 0.142857142857 | GMPR2 GMPR | Purine salvage |
| GO:0016491 | 0.0146463063513 | 0.5 | ACOX1 MTHFD1 TXNDC17 IDH1 GMPR2 IDH2 GMPR | oxidoreductase activity |
| KEGG:00020 | 0.0174455540926 | 0.142857142857 | IDH1 IDH2 | Citrate cycle (TCA cycle) |
| HP:0005701 | 0.0178906357032 | 0.142857142857 | IDH1 IDH2 | Multiple enchondromatosis |
| REAC:R-HSA-196757 | 0.0217138819978 | 0.142857142857 | MTHFD1 MTHFD1L | Metabolism of folate and pterines |
| WP:WP241 | 0.0220987305014 | 0.142857142857 | MTHFD1 MTHFD1L | One Carbon Metabolism |
| HP:0100764 | 0.0229898903218 | 0.142857142857 | IDH1 IDH2 | Lymphangioma |
| GO:0051186 | 0.0251886955963 | 0.428571428571 | ACSF3 MTHFD1L MTHFD1 IDH1 NAXE IDH2 | cofactor metabolic process |
| WP:WP2525 | 0.0254037752287 | 0.142857142857 | MTHFD1 MTHFD1L | Trans-sulfuration and one carbon metabolism |
| REAC:R-HSA-196849 | 0.0341292395524 | 0.214285714286 | NAXE MTHFD1L MTHFD1 | Metabolism of water-soluble vitamins and cofactors |
| GO:0048702 | 0.0410249304355 | 0.142857142857 | MTHFD1 MTHFD1L | embryonic neurocranium morphogenesis |
| GO:0015951 | 0.0410249304355 | 0.142857142857 | GMPR2 GMPR | purine ribonucleotide interconversion |
| GO:0015950 | 0.0410249304355 | 0.142857142857 | GMPR2 GMPR | purine nucleotide interconversion |
| GO:0009257 | 0.0410249304355 | 0.142857142857 | MTHFD1 MTHFD1L | 10-formyltetrahydrofolate biosynthetic process |
| GO:0016657 | 0.0410249304355 | 0.142857142857 | GMPR2 GMPR | oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor |
| GO:0004450 | 0.0410249304355 | 0.142857142857 | IDH1 IDH2 | isocitrate dehydrogenase (NADP+) activity |
| GO:0004329 | 0.0410249304355 | 0.142857142857 | MTHFD1 MTHFD1L | formate-tetrahydrofolate ligase activity |
| GO:0003920 | 0.0410249304355 | 0.142857142857 | GMPR2 GMPR | GMP reductase activity |
| REAC:R-HSA-8956321 | 0.0475912415267 | 0.142857142857 | GMPR2 GMPR | Nucleotide salvage |
| KEGG:00480 | 0.0499921318021 | 0.142857142857 | IDH1 IDH2 | Glutathione metabolism |
| CORUM:404 | 0.0499987143188 | 0.0714285714286 | IDH1 | Isocitrate dehydrogenase [NADP], cytoplasmic |
| CORUM:6948 | 0.0499987143188 | 0.0714285714286 | IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GMPR2 | GMPR | 0.991 | 0.911 | bioplex (GMPR2) bioplex_WMM |
| MTHFD1L | IDH2 | 0.991 | 0.911 | bioplex_WMM youn_WMM fraction treiber_WMM |
| MTHFD1 | IDH2 | 0.991 | 0.91 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IDH1 | MTHFD1L | 0.955 | 0.862 | bioplex_WMM youn_WMM fraction |
| TXNDC17 | IDH2 | 0.937 | 0.85 | bioplex_WMM fraction |
| GMPR | MTHFD1L | 0.935 | 0.85 | fraction |
| MTHFD1 | GMPR | 0.873 | 0.805 | fraction |
| IDH1 | GMPR | 0.794 | 0.76 | fraction |
| IDH1 | IDH2 | 0.733 | 0.738 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IDH1 | TXNDC17 | 0.682 | 0.71 | bioplex_WMM fraction |
| IDH1 | GMPR2 | 0.625 | 0.678 | fraction |
| IDH1 | NAXE | 0.538 | 0.642 | bioplex_WMM fraction |
| ACSF3 | IDH2 | 0.5 | 0.621 | bioplex_WMM youn_WMM fraction |
| IDH1 | UBQLN4 | 0.439 | 0.584 | bioplex_WMM fraction |
| NAXE | GMPR2 | 0.352 | 0.538 | bioplex (GMPR2) fraction |
| TXNDC17 | MTHFD1L | 0.309 | 0.502 | bioplex_WMM fraction |
| NPEPL1 | IDH2 | 0.302 | 0.497 | fraction |
| GMPR | IDH2 | 0.291 | 0.492 | fraction |
| NPEPL1 | MTHFD1L | 0.267 | 0.483 | fraction |
| GMPR2 | MTHFD1L | 0.264 | 0.482 | fraction |
| GMPR2 | IDH2 | 0.261 | 0.482 | fraction |
| NAXE | MTHFD1L | 0.176 | 0.435 | bioplex_WMM fraction |
| ACOX1 | IDH2 | 0.174 | 0.434 | bioplex_WMM fraction |
| TRAP1 | ACSF3 | 0.162 | 0.42 | bioplex (ACSF3) bioplex_WMM fraction |
| UBQLN4 | MTHFD1L | 0.147 | 0.409 | bioplex_WMM fraction |
| GMPR2 | TXNDC17 | 0.136 | 0.407 | fraction |
| TRAP1 | MTHFD1L | 0.136 | 0.406 | bioplex_WMM fraction treiber_WMM |
| NPEPL1 | NAXE | 0.134 | 0.405 | fraction |
| TXNDC17 | FARS2 | 0.132 | 0.405 | fraction |
| UBQLN4 | ACSF3 | 0.126 | 0.4 | fraction |
| ACOX1 | MTHFD1L | 0.107 | 0.373 | bioplex_WMM fraction |
| FARS2 | IDH2 | 0.102 | 0.365 | fraction |
| NAXE | GMPR | 0.096 | 0.358 | fraction |
| ACOX1 | TXNDC17 | 0.094 | 0.356 | bioplex_WMM fraction |
| TRAP1 | MTHFD1 | 0.088 | 0.354 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| UBQLN4 | IDH2 | 0.083 | 0.35 | bioplex_WMM fraction |
| FARS2 | MTHFD1L | 0.068 | 0.347 | bioplex_WMM fraction |
| NPEPL1 | MTHFD1 | 0.064 | 0.349 | fraction |
| GMPR2 | MTHFD1 | 0.064 | 0.347 | bioplex (GMPR2) fraction |
| ACOX1 | MTHFD1 | 0.056 | 0.313 | bioplex_WMM fraction |
| NAXE | UBQLN4 | 0.05 | 0.298 | bioplex_WMM fraction |
| ACSF3 | TXNDC17 | 0.047 | 0.293 | fraction |
| TRAP1 | IDH2 | 0.045 | 0.279 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| ACOX1 | FARS2 | 0.043 | 0.269 | bioplex_WMM fraction |
| NAXE | TRAP1 | 0.041 | 0.267 | bioplex_WMM fraction |
| UBQLN4 | ACOX1 | 0.04 | 0.267 | bioplex_WMM fraction |
| IDH1 | MTHFD1 | 0.031 | 0.239 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| NAXE | ACOX1 | 0.025 | 0.218 | bioplex_WMM fraction |
| ACSF3 | GMPR | 0.025 | 0.211 | fraction |
| TRAP1 | ACOX1 | 0.02 | 0.186 | bioplex_WMM fraction |
| NAXE | ACSF3 | 0.02 | 0.184 | fraction |
| NAXE | MTHFD1 | 0.017 | 0.168 | bioplex_WMM fraction |
| GMPR2 | ACSF3 | 0.016 | 0.161 | fraction |
| ACSF3 | ACOX1 | 0.013 | 0.155 | fraction |
| TRAP1 | UBQLN4 | 0.01 | 0.102 | bioplex_WMM fraction |
| NAXE | TXNDC17 | 0.008 | 0.04 | bioplex_WMM fraction |
| IDH1 | ACOX1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| MTHFD1 | FARS2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| TRAP1 | FARS2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| ACSF3 | MTHFD1 | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| GMPR2 | TRAP1 | 0.007 | 0.006 | bioplex (GMPR2) |
| UBQLN4 | GMPR | 0.007 | 0.001 | fraction |
| TRAP1 | TXNDC17 | 0.006 | 0.007 | bioplex_WMM fraction |
| TXNDC17 | MTHFD1 | 0.006 | 0.01 | bioplex_WMM fraction |
| GMPR2 | UBQLN4 | 0.005 | 0.01 | fraction |
| ACSF3 | MTHFD1L | 0.005 | 0.013 | bioplex (ACSF3) bioplex_WMM youn_WMM |
| UBQLN4 | MTHFD1 | 0.005 | 0.009 | bioplex_WMM fraction |
| ACOX1 | GMPR | 0.005 | 0.012 | fraction |
| IDH1 | TRAP1 | 0.003 | 0.013 | bioplex_WMM Guru fraction boldt_WMM treiber_WMM |
| NAXE | IDH2 | 0.003 | 0.012 | bioplex_WMM fraction |
| MTHFD1 | MTHFD1L | 0.0 | 0.012 | bioplex_WMM youn_WMM fraction treiber_WMM |
| GMPR2 | ACOX1 | 0.0 | 0.013 | fraction |
| UBQLN4 | TXNDC17 | 0.0 | 0.004 | bioplex_WMM fraction |
Images
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Complex HuMAP2_00843 has an average edge precision of 0.343 which is ranked 4091 out of all 6965 complexes.
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